ID   A0A182K5K1_9DIPT        Unreviewed;      1099 AA.
AC   A0A182K5K1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles christyi.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR006036-PA, ECO:0000313|Proteomes:UP000075881};
RN   [1] {ECO:0000313|Proteomes:UP000075881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACHR006036-PA}
RP   IDENTIFICATION.
RC   STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR006036-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182K5K1; -.
DR   STRING; 43041.A0A182K5K1; -.
DR   EnsemblMetazoa; ACHR006036-RA; ACHR006036-PA; ACHR006036.
DR   VEuPathDB; VectorBase:ACHR006036; -.
DR   OrthoDB; 1404660at2759; -.
DR   Proteomes; UP000075881; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24096:SF353; GH16244P-RELATED; 1.
DR   PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
PE   3: Inferred from homology;
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          39..398
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          450..526
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   DOMAIN          596..950
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          1001..1079
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   1099 AA;  121079 MW;  0DC5511732E60920 CRC64;
     MTDYRTVYDE ATRTWYGPTV KHLFNPEASL GQIMLEVLSR SPDRVMQQDM DTGRSLTYGE
     FRMRLIRFAQ NLTEAGVRRG DMVALANANS ENLAPLACAL LTIGVPFNPL APTFNEHDMA
     NMLRTTKPKL VFADADNYEV VRKALERTVS NGDTIPPIYV FECTRGDVKH AEDLMKKTGR
     EERATYLGDS NKIVAAVLCS SGTSGAHKGV QVTHAAIMQV TIMSRFVSAR TVHFTFSALY
     WTTGFSTMLN AFFNGATRLI TRQPFNEELL LKAVEKCRAN AIFVPTAYAN TMMAYPRIKT
     ADLSSLKVWA LGGSPVPEEL RDRIDALLAP HGGYSVNAYG SSENGGIAID MLKRTAGAIG
     PLMPNVIVRV VDEEGNRMGV GERGELLTKT NVAFGGYYGN EEASTSAIDS EGFLRTGDIG
     YIDEQGLLYL VDRKKDIFKY RGYHVSPTDL EAIIMRIEGV QDVCVVGVPD AEGATDLPSA
     VIVRRPGSKL DASQVCSTVA GQVSDFKRLR GGVHFIAELP KTDTGKVLRR KVTEIVASMN
     QHPKLTSMAS VEKKSRTKME LCTYDANSRT WYGVQNVSIY NPKTNVGEVL NHILLRTPDR
     IIQIDMDTDS RLSCAEFRMR MIRFAQHLTD VGLRKGDIVA MANGNSENVA PLACALMTLG
     APFNPLAPGF NVEDMAHMLR LTQPKIVFCD EANVEVVRKA VRSVFDGEIP IYVFESKRDD
     VRHAEDLLKP TGREEQFIPA HLGDSHELLS MIVCSSGTTG PPKGVCVTHA QTVATIGSYP
     MAKPMTVFNF SPLYWGTGVY MLLSTFSGAS TRLITRRPFS EETFFEAVEK YRANFAFMPP
     SYGSQIARHE RAPHVDFSSL RMLSLGGSYV SDGLRDRLDR LLPNGRTYNS VGTSEIGWVS
     CDLAKRKPGS VGTPVINIAI KIVDDAGNDL GVGEQGQVLL KGSEPFIGYY KNEEATRATI
     DERGFTRSGD VGYVDEEGYL YLIDREKDIF KYRGFHISPS ELEAIIGQIE GVLEVCVVGV
     PADEERTTEL PTAAIVRAAG SSLTAEQVME IVDGKVSDFK RLRGGVYFVD HLPKTQSGKN
     LRRKVLSMVL ELVKDNTES
//