ID   A0A182K990_9DIPT        Unreviewed;      1156 AA.
AC   A0A182K990;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 29.
DE   RecName: Full=IRS-type PTB domain-containing protein {ECO:0000259|PROSITE:PS51064};
OS   Anopheles christyi.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR007327-PA, ECO:0000313|Proteomes:UP000075881};
RN   [1] {ECO:0000313|Proteomes:UP000075881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACHR007327-PA}
RP   IDENTIFICATION.
RC   STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR007327-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182K990; -.
DR   STRING; 43041.A0A182K990; -.
DR   EnsemblMetazoa; ACHR007327-RA; ACHR007327-PA; ACHR007327.
DR   VEuPathDB; VectorBase:ACHR007327; -.
DR   OrthoDB; 5394416at2759; -.
DR   Proteomes; UP000075881; Unassembled WGS sequence.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR037746; Dok-7.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21636; PROTEIN DOK-7; 1.
DR   PANTHER; PTHR21636:SF2; PROTEIN DOK-7; 1.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM01244; IRS; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51064; IRS_PTB; 1.
PE   4: Predicted;
FT   DOMAIN          74..179
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          657..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          806..946
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1126..1156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..687
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..737
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..836
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..884
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..916
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        923..946
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1126..1149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1156 AA;  125267 MW;  C2D308F546A951FB CRC64;
     CLHLQLYRDS KDRYKNGQTK ASLSLQHFLG VESGFTLDKE SNTIAIICQD VIVVLAFDTR
     ERLIQWQVKI SNNLGDDLQY LVLVSSAPPK AKLSTGPARM HIQDHRFCLT TGVPPRLTGL
     WQIEHLRRYG VVDNRFCFEG GSSCGKGEGL YVFVTDLGEE ITHTFKLASQ GKLASKKRAT
     ARKIAALDSP RKGSESRSTN YNDEICTVHI ENSSCTCRNS YWPSTESRDL DSNYGCGDTA
     SVSECHDSIN DLDSFPRNTV ANLERCMSCI SKLGAPSMSR SSTITGTPGA VAPLPAWHML
     TEHNNHINQT HKLPAPQLAL DRMSLCSHGS SNNSEYSIPR QTCGAAPGES SWYEKAPSQQ
     GAVCNHHRST SPCSCSCPSV PGRPPKPRDI PLHITAPIHT AISMTTGKTP QHQHSVGPYE
     NYDIPKTPVA IEGSSSSGCT PGENYDTPKK IQEYLSKEET VESATSGYGN YDMPMSLTKA
     VCSCLSGGAG DMPVQPPPFK GSERVECTCH RVMSWADNWI SLPLCKRGNG IENTTVQVNK
     VKLSGEGKMP VMDASGTGDG SGAIYATVDM TKKIRKKLEQ VACACEEPLV TQPQPSGPKQ
     LPASCYDNYE DVEIKPDTGA NYANLEFERS LENYENSKEV LQRAGLCLAG MASEEEEPRV
     CHKCGHPSAK TPDSDEHRPD GGGEQTSADD KQENYMMMEP GNKKSKFPGY IPMSPAAPTA
     ATGNEPTDGT VSPTAPPLPS KSDLLKQRMS RIIGEKSASN PSLCGPVVDR SRKRIDDESR
     VPGSAMLRAT LASPYARKQL MDSSDLLPSC GAEKRLSPRK RSASAESSRF LDAEGEEIES
     PLSGTASPST ETLLRKTPTP NGTTTTTSLR RSSSPCVHQE TETCDKTVTA TEAEDDLSAS
     TNPASSQTSQ SVYIRRSESV PCKAQNRDSS SSNDSGVSTG SLRQRGTDFT DFELPLTTAM
     SARRHQRHIL PAQNCVHASL PRRSKSFDPL RELSFQFQKA RVPEKSTSAE AEVPVCPPKA
     KDVMAGVPGA PYIDSRSTSS GTSDMSDYIE TLSLSSHSSS DTPEGMRHIR QATSTLRPRS
     GKEYQNIDRS ILSLTQASTD AIKVPGTPSQ LRGLLSCSAN YANITPVPEN AESPSPGYQS
     GTSPQDAQGQ HFMFKL
//