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Database: UniProt
Entry: A0A182L6K5_9DIPT
LinkDB: A0A182L6K5_9DIPT
Original site: A0A182L6K5_9DIPT 
ID   A0A182L6K5_9DIPT        Unreviewed;       393 AA.
AC   A0A182L6K5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-JUL-2019, entry version 15.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
OS   Anopheles coluzzii.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=1518534 {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM032859-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM032859-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882,
RC   ECO:0000313|VectorBase:ACOM032859-PA};
RX   PubMed=20966253; DOI=10.1126/science.1195755;
RA   Lawniczak M.K., Emrich S.J., Holloway A.K., Regier A.P., Olson M.,
RA   White B., Redmond S., Fulton L., Appelbaum E., Godfrey J., Farmer C.,
RA   Chinwalla A., Yang S.P., Minx P., Nelson J., Kyung K., Walenz B.P.,
RA   Garcia-Hernandez E., Aguiar M., Viswanathan L.D., Rogers Y.H.,
RA   Strausberg R.L., Saski C.A., Lawson D., Collins F.H., Kafatos F.C.,
RA   Christophides G.K., Clifton S.W., Kirkness E.F., Besansky N.J.;
RT   "Widespread divergence between incipient Anopheles gambiae species
RT   revealed by whole genome sequences.";
RL   Science 330:512-514(2010).
RN   [2] {ECO:0000313|VectorBase:ACOM032859-PA}
RP   IDENTIFICATION.
RC   STRAIN=Mali-NIH {ECO:0000313|VectorBase:ACOM032859-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   VectorBase; ACOM032859-RA; ACOM032859-PA; ACOM032859.
DR   Proteomes; UP000075882; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075882};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075882};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      237    267       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      268    393       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   393 AA;  43604 MW;  72D950B3E8261EB6 CRC64;
     MPGGRTAQRQ VILRERLQER DVLCLVQFYV QNDSSRNAFL LEGIVWRQSQ LIDEFLYGYG
     CSTGGPCGLQ LGLSRFGARV LTCYCEGHCP GNVQNGTCET RPGGSCFVSV EAVLDEETKQ
     LVPEYSHGCM SPEQGGGLLQ CKVGTVSPQL HGKSIVCCDN EDLCNQDLQP PYSPRTTTTP
     EPPLADPNSM HLFALTLSVC LCVGGLVVLL GAFFWVYRRR EKRKPAYLMN SLYNTTNGHM
     PIADLVEQTS GSGSGLPLLV QRTIAKQIQM VHSVGKGRYG EVWLAKWRDE KVAVKIFFTT
     EESSWFRETE IYQTVLMRNE NILGFIAADI KGTGSWTQML LITDYHELGS LHDYLQKRVL
     NPHMLKTLAH SLASGVAHLH TEIFGTPGKP TKA
//
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