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Database: UniProt
Entry: A0A182L8Q7_9DIPT
LinkDB: A0A182L8Q7_9DIPT
Original site: A0A182L8Q7_9DIPT 
ID   A0A182L8Q7_9DIPT        Unreviewed;       546 AA.
AC   A0A182L8Q7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   31-JUL-2019, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:ACOM033884-PA};
OS   Anopheles coluzzii.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=1518534 {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM033884-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM033884-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882,
RC   ECO:0000313|VectorBase:ACOM033884-PA};
RX   PubMed=20966253; DOI=10.1126/science.1195755;
RA   Lawniczak M.K., Emrich S.J., Holloway A.K., Regier A.P., Olson M.,
RA   White B., Redmond S., Fulton L., Appelbaum E., Godfrey J., Farmer C.,
RA   Chinwalla A., Yang S.P., Minx P., Nelson J., Kyung K., Walenz B.P.,
RA   Garcia-Hernandez E., Aguiar M., Viswanathan L.D., Rogers Y.H.,
RA   Strausberg R.L., Saski C.A., Lawson D., Collins F.H., Kafatos F.C.,
RA   Christophides G.K., Clifton S.W., Kirkness E.F., Besansky N.J.;
RT   "Widespread divergence between incipient Anopheles gambiae species
RT   revealed by whole genome sequences.";
RL   Science 330:512-514(2010).
RN   [2] {ECO:0000313|VectorBase:ACOM033884-PA}
RP   IDENTIFICATION.
RC   STRAIN=Mali-NIH {ECO:0000313|VectorBase:ACOM033884-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   VectorBase; ACOM033884-RA; ACOM033884-PA; ACOM033884.
DR   Proteomes; UP000075882; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075882};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075882};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    122    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    205    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    233       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      240    411       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     23       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      503    527       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS      1     20       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   546 AA;  62342 MW;  E8CAB92A3A3640B5 CRC64;
     MNYDSDQQQQ QQQQSLSLAP DGTGRWDRSM LKLGPFDPPH SPGGYGEQFG YSSPITPVTP
     NTPLVCYPMK NRVLRPGVNR KYRKRAILKN GDCNVVLSRP PRQHLRFLQD IFTTLVDAQW
     RWTLLVFAFS FVGSWLFFAV IWWLISYTHG DLEELHLPDN QSEIGWIPCV YNIYSFTSAF
     LFSIETQHTI GYGVRTTTEE CPEAIFVMCF QSIYGLMIQA FMVGIVFAKM TRPKQRSQTL
     LFSKNAVVCQ RDGELCLMFR VGDMRKSHII GASVRAQLIR TKTTREGETM AQYQHELDVG
     SDGSSSELFF IWPQIVVHRI DKNSALYNMS ASDMLRERFE VVVILEGTVE STGQSTQARS
     SYVNTEILWG HRFEPVVCYN REQQGYEINY SKFDSTLQVD TPLCSARELA EFYRAQDDYR
     PPTDVGDNMS TKTQLERRWK DHYSTIVNTL SQYHLADEAG VGGGTDHLYP TRYLTIQGVP
     RRRKSYVALQ NNLWNLFDRP PNPRLKITPK EDGAGSPRRV SDDDPIVNSV TVQNINERFT
     AGGGGA
//
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