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Database: UniProt
Entry: A0A182LKU8_9DIPT
LinkDB: A0A182LKU8_9DIPT
Original site: A0A182LKU8_9DIPT 
ID   A0A182LKU8_9DIPT        Unreviewed;      2989 AA.
AC   A0A182LKU8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   07-NOV-2018, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:ACOM039669-PA};
OS   Anopheles coluzzii.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=1518534 {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM039669-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM039669-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882,
RC   ECO:0000313|VectorBase:ACOM039669-PA};
RX   PubMed=20966253; DOI=10.1126/science.1195755;
RA   Lawniczak M.K., Emrich S.J., Holloway A.K., Regier A.P., Olson M.,
RA   White B., Redmond S., Fulton L., Appelbaum E., Godfrey J., Farmer C.,
RA   Chinwalla A., Yang S.P., Minx P., Nelson J., Kyung K., Walenz B.P.,
RA   Garcia-Hernandez E., Aguiar M., Viswanathan L.D., Rogers Y.H.,
RA   Strausberg R.L., Saski C.A., Lawson D., Collins F.H., Kafatos F.C.,
RA   Christophides G.K., Clifton S.W., Kirkness E.F., Besansky N.J.;
RT   "Widespread divergence between incipient Anopheles gambiae species
RT   revealed by whole genome sequences.";
RL   Science 330:512-514(2010).
RN   [2] {ECO:0000313|VectorBase:ACOM039669-PA}
RP   IDENTIFICATION.
RC   STRAIN=Mali-NIH {ECO:0000313|VectorBase:ACOM039669-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
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DR   VectorBase; ACOM039669-RA; ACOM039669-PA; ACOM039669.
DR   Proteomes; UP000075882; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075882};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075882};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2516   2538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2545   2565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2571   2586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2593   2616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2636   2661       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2681   2703       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2810   2833       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      176    228       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      299    365       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      371    427       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2989 AA;  333824 MW;  9059BE0DDA2357E9 CRC64;
     MGDSTIGSVS FLHLGDIVSL YSEGSVSGFL STLGLVDDRV VVCPGAGDLN EPPEKFRDCL
     IKICPMNRYS AQKQFWKAAK QSTTTNTDTS LLKRLHHAAE IEKKQNESEN KKLLGTVVQY
     GSVVQLLHLK SNKYVTVNIR LPALLEKNAM RVYLDANGNE GSWFYIMPFY KLRSAGDNVV
     VSDKVILKPV NANRQNLHVA VTYELPDNPG SKEVNVLNSS TSWKITLFME QRENQEDVLK
     GGDVVRLFHA EQEKFLTMDE YKKQQHVFLR TTGRSSATAA TSSKALWEVE VVQHDSCRGG
     AGHWNSLFRF KHLATGYYLA AEIDEDISRT EKSSSSSHPQ GGDSFRLVPV PHSSDIASVF
     ELDSTTITRP EGLVPQSSYV RLRHLCSSTW VHATSVPIDI DDDKPVMSKV GCSAIKEDKE
     AFQLIPVSPV EVRDLDFAND ACKLLLAMST KLENGTISSN ERRSLIALLQ DIVFFIAGQE
     NDQNKSDALD LTINNPNRDR QKLLREQYIL KQLFKILQGP FQETKNNDGP FLKIDELGDP
     KNAPFKNIFR LCYRILKLSQ QDYRKNQEYI AKHFGLMQKQ IGYDILAEDT ITALLHNNRK
     LLEKHITAAE IETFVGLVRK NMQSWQSRFL DYLSDLCVSN KKAIAVTQEL ICKSVLSSKN
     ADILIETFLR EVDDDPLGYL SELERGNREF TEIREVDESS SGVEGDSKGT TNGKRKLDEK
     KRYEVVLMWT NRTQSKSMSR LAQGLKIGRA VDTAILDYYR HQLNLFSNMC LNRQYLALNN
     LSPHLDIDLI LRCMSDKTVP YDLRASFCRL MLHLHVDRDP QEPVTPVKYA RLWSEIPTVM
     SINDYDIEKQ LDSNKEAVRA RFNKTIAFVE DYLCNHVVSK MWFADQDQNK LTFEVVKLAR
     DLIYFGFYSF SDLLRLTKTL LNILDCVSSS EADGTGLPTG HIDSEGGVLR RIGDMGAVMT
     SLTLGPISTA IVSPTIQHRK SVSQLMKEYP LVMDTKLKII EILQFILDVR LDYRISCLLS
     IFKREFDENE QTASTGAALA PPTVIVPETP TIIPPGGGGV PSTTNDATSP AVSVVVPPAD
     SVSQDANSSM GGDTTSEVSL TLSNTTVEST TTTNASDSTS EGHGTMSSEG GTSMTDGLSS
     SGGSKATDTS LPPTAENINL RQKNIDLESI GYQAEGIFGC TEDTYNPLDL DGQGGRTFLR
     VLLHLIMHEY PALVSGALHL LFRHFSQRHE VLHAFRQVQL LVSDSDVESY KQIKSDLDVL
     RQSVEKSELW VYKSKQTDDL LAGGGGEGGE GGDGSGGKGG EQGEGGAGGG GKSASAKGKP
     ELVKQESQLN FDQGPELNPE QSQEYKKIQQ ILIRMNKLCI TATGPDGFVK PRKHEQRLLR
     NVGVHTVVLD LLQIPYDEKD DYRMNELMRL AHEFLQNFCL GNQQNQILLH KQLDLFLNPG
     ILEAETVCAI FKDNLNLCNE VSDKVVQHFV HCIEIHGRHV EYLKFLQTII KAENQFIRKC
     QDMVMQELVN AGEEVLVFYN DKGSFNYFVE LMRSYSAGTL ADPSPLMYHI ELVKLLACCT
     MGKNVYTEIK CNSLLALDDI VAMISHPDCI PEVKVAYVDF LCHCYIDTEV EVKEIYSSNH
     MWCLFEKSFL IDINNVVKGG SFTNKQLENY VCNEVMNILT TFFNSQFSDQ STALQKRQLI
     FVKILQNSFK LTQCKGLTPS QRFNVENCIR TLSEKAKPRG IAIPIDLENQ VVKMFNKTAM
     LSRQTSKWLL VTKQTKMERS QSQIMRMDRS IIEGLQDIVS LLEDKLKPLV EAEQSLLVDI
     LYRSELLFPL NTESRKKCET GDFIRHLIKH TEKLLEEKEE KLCVKILKTL KEMMTIDCDY
     GDKGDHLRTI LLKRYFGNDF TLQAPVAALP GAVGPAVLQP ANVSTAVGSP MASVSHGPGA
     KYLIRAGRTL HEVQNHLDKE GASDLVIELV IKSINSPSIF VEAIELGIAL LEGGNPIIQK
     GMYNKFLSND LSQSFFKVFF DKMKDAQQEI KSTVTVNTSD MAANKASESK VEGKDLDKIG
     QRKNVNKVNG IVITEDFKEE LQNAALMTQQ SYINARNLAA ASDGTGSDNG DENSLMSIGS
     SALEDILAEK LEKHKDKDEN NKLSNKVLVM QPILRFLQLL CENHNPELQN LLRNQNNKTN
     YNLVSETLMF SGLYLRLDDG WAGIVGVNNV SLINQTLETL TEYCQGPCHD NQNCIATHES
     NGLDIITALI LNDINPLGKN RMDLVLELKN NASKLLLAIM ESRGDSENAE RILANMNPKQ
     LVEVACRAYH QDENILMLLN QSDGGGGGSG VGGGGGRGGG GVDDGYGGLR HDLGDDGHDD
     DDVGVSPKEV GHNIYILCHQ LAQHNKELAG LLKIDTYNGS GTAGSNAAPI VPTFPGANPS
     SLGGGPPSSA SANSAASKAN SKTNQALLYY QTHTAQIEIV RHDRTLEQIV FPIPEICEYL
     TKDTKVRVLN TAERDDQGSK VADFFDRHEA MFNEMKWQKK LRGQPALFWV SSYMSLWSNI
     LFNLAVLINL IVAFFYPFEN ALPELSFHLS SLIWIVMLVS LAIVITLPRQ SGIRTFVVAL
     ILRLIFSCGP EPTLWLLGCI TVIMKGVHII SLMGNYGTLE KHFVSIITDA ELLYHFFYLL
     FCVFGVLLHP FFFSILLFDV VYREETLLNV IRSVTRNGRS IILTAVLALI LVYMFSIIGY
     MFFRDDFLVP VDEEYTPPAI PSAGDAGCTG DSATVSHMVP PDVVEQVVQA TCSKPPGTAS
     TELADDGGEM KERGLRLNDH GLRNGGGIGD ILRAPSRKET LFVPRVVYDL LFFFIVIIIV
     LNLIFGVIID TFADLRSEKQ QKELILKNTC FICGLNRSAF DNKTVSFEEH IKNEHNMWHY
     LYFIVLVKVK DPTEFTGPES YVHAMVKANI QDWFPRLRAM SLAAVDGDGE QIELRSLKNL
     LETNHIAVRE LMTQIMELEN KIWKMIRMLR IVQMKQMSTG RMTMKRSDL
//
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