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Database: UniProt
Entry: A0A182LR49_9DIPT
LinkDB: A0A182LR49_9DIPT
Original site: A0A182LR49_9DIPT 
ID   A0A182LR49_9DIPT        Unreviewed;       643 AA.
AC   A0A182LR49;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   05-DEC-2018, entry version 12.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
OS   Anopheles coluzzii.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=1518534 {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM042300-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075882, ECO:0000313|VectorBase:ACOM042300-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mali-NIH {ECO:0000313|Proteomes:UP000075882,
RC   ECO:0000313|VectorBase:ACOM042300-PA};
RX   PubMed=20966253; DOI=10.1126/science.1195755;
RA   Lawniczak M.K., Emrich S.J., Holloway A.K., Regier A.P., Olson M.,
RA   White B., Redmond S., Fulton L., Appelbaum E., Godfrey J., Farmer C.,
RA   Chinwalla A., Yang S.P., Minx P., Nelson J., Kyung K., Walenz B.P.,
RA   Garcia-Hernandez E., Aguiar M., Viswanathan L.D., Rogers Y.H.,
RA   Strausberg R.L., Saski C.A., Lawson D., Collins F.H., Kafatos F.C.,
RA   Christophides G.K., Clifton S.W., Kirkness E.F., Besansky N.J.;
RT   "Widespread divergence between incipient Anopheles gambiae species
RT   revealed by whole genome sequences.";
RL   Science 330:512-514(2010).
RN   [2] {ECO:0000313|VectorBase:ACOM042300-PA}
RP   IDENTIFICATION.
RC   STRAIN=Mali-NIH {ECO:0000313|VectorBase:ACOM042300-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   VectorBase; ACOM042300-RA; ACOM042300-PA; ACOM042300.
DR   Proteomes; UP000075882; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000075882};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075882}.
FT   DOMAIN       44    363       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      584    621       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    192    192       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    272    272       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   643 AA;  72703 MW;  DC359B710EB56FAD CRC64;
     LWKTNCTNNM ATVVCTLFAL VFLLAAPRSV DMRLFSIDYD NDTFVMDGKP FQYVAGSFHY
     FRALPESWPS ILRSMRAAGL NAVTTYVEWS LHNPKEDVYN WQGMANIEHF LELADSAGLY
     VILRPGPYIC AERDMGGFPS WLLHKYPDIL LRTNDLRYLR EVRTWYAQLL SRVQRFLVGQ
     GGPIIMVQVE NEYGSFYACD HKYLNWLRDE TERYVMGNAV LFTNNGPGLE GCGAIEHVLS
     SLDFGPGTED EINGFWTTLR KTQPKGPLVN AEYYPGWLTH WQEPHMARTD TKPVVDSLDF
     MLRNKVNVNI YMFFGGTNYG FTAGANNMGA GGYAADLTSY DYDAPLDESG DPTPKYFALR
     DTILKYFPKP DLPVPQPTNK VQLPPLNMTR LGSLLDPSLL ERLATQTVTS RLPLSFEALN
     QVSGLVLYET LLPDDIRTDP RKLIVEGVHD RGYVFVGDQF VGVLSRENQI NTLPLALDAG
     QTLRIAVENQ GRINFGIASD GKGILGSVFV NTRQLYNWTM YGLPLSDFKP IVHAIRHHRK
     HHHRVRRASQ TAGTPMSLYY AIFDIEGQLA DTYLDPTGWG KGIVFVNGFL LGRYWPTVGP
     QVTLYLSRHL LTQKNNYLAV IEYQKEFGDS IPPLKFSATP SFN
//
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