ID   A0A182LRC2_9DIPT        Unreviewed;       899 AA.
AC   A0A182LRC2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles culicifacies.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; culicifacies species complex.
OX   NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA000046-PA, ECO:0000313|Proteomes:UP000075883};
RN   [1] {ECO:0000313|Proteomes:UP000075883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles culicifacies species A.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACUA000046-PA}
RP   IDENTIFICATION.
RC   STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA000046-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
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DR   EMBL; AXCM01000926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182LRC2; -.
DR   STRING; 139723.A0A182LRC2; -.
DR   EnsemblMetazoa; ACUA000046-RA; ACUA000046-PA; ACUA000046.
DR   VEuPathDB; VectorBase:ACUA000046; -.
DR   OrthoDB; 168255at2759; -.
DR   Proteomes; UP000075883; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          248..574
FT                   /note="DNA mismatch repair protein MutS core"
FT                   /evidence="ECO:0000259|SMART:SM00533"
FT   DOMAIN          591..802
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|SMART:SM00534"
FT   REGION          22..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   899 AA;  101315 MW;  91BC1FC3596B3AB0 CRC64;
     MNFIPYRSKS VPPLVAGGLP VRLRGRETDR NERSMPYNRS RSMAGVRHEL TTSMPNASGQ
     PDRSGSNAGR DGAYVIVVIA EGRGHAALEV GLAAIDVTSP HLKLTQYGDN FWYSVTLTTL
     HSLDPTVVYF SEHALTNGTS YLPKLIHQFL PQTKVLGLGR SYFNDSIAES YMSQLCSRDY
     AKLRGLIHSK YYGLASCGAL LRHCIETALL QIATRTLKLS YIDKMSTMTM DVECIGQLEL
     LGPLQKGDEK QSLFGFMNRC ITSIGKRHLR ANIIEPWTSR ARLEMRLQCI RELLGKPTLL
     QAIRRTLTEV KDVGGLLRLS VDIDRMKTTH QNTIHMLNQA SSLRNVLKVV PKLRDLLRDI
     HADYLNDLKQ TLQEPAYAEL LAKIWEVLDD SPVERNTTYN RLFLVRAKVN SILDLLRTLY
     SGVIDEIRQY VAELSLATRM QLKLHHSKPN GFHLLYVLAN DEVDNVAEQL SRNFQILSRN
     GRRYTLTNGR LMAFNDKLSA VGKEIDEISY GIIRGLIASI RDSIDAVYNL VGCLTDLDVV
     QALATVSQGK EFCEPTFGEE TKIVSGRHPL LENFSGGRTI VRNNVISTPE YNVFIVTGPN
     MSGKTVYMKT ICVLQIMAQL GCYIPAAQAQ VRIVDRLLTI FGDADNLQQD DTESCQMYNK
     LQFVRHCLTA NSLIVIDELY GDTHLPDTSS AKWALLERII DHVGHAEERR EEAPVPTLSS
     IRKPFIFITT HCMELLRPLE IHHNVSQLCL QTETVQVDGV ERLRYKYVVV EGRTAVKSYG
     LSLARTVNIP KDVLDRAEQL CRVDLKQHLA ECATNNRSHN RTGNLSTTTS HTLSTQGSFN
     EFFKLFYHIY GKVANSARNA VDVQQHLTEQ LNQFLASVPE EVREFLRVTP LEQLLQLDA
//