ID A0A182LT93_9DIPT Unreviewed; 1120 AA.
AC A0A182LT93;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Ion transport domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA001395-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA001395-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA001395-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AXCM01009170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182LT93; -.
DR STRING; 139723.A0A182LT93; -.
DR EnsemblMetazoa; ACUA001395-RA; ACUA001395-PA; ACUA001395.
DR VEuPathDB; VectorBase:ACUA001395; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..286
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 378..433
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 520..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 125160 MW; 84ED71AADC12EFAF CRC64;
MSTFKVSLTD SENTQYKDYL FDSDGRQQRP LKLKKKFYEF YTAPITKFWA DSMAYVFFLV
LFTYTVLVRM EETPSWQEVY AISYITTLGC EKIREIVSSE PVAISHKFSV WAWNMWNPCD
AAAIIFFHIG LALRLRPYTM DIGRVIYCVD SIYWYLRILN ILGVNKYLGP LVTMMGKMVK
NMIYFVVLLL VVLMSFGVSR QAILFPNNDA SWRLVRDVYY QPYFMLYGEV FADDIDPPCG
EDPSQPPCVT GHWVTPIAMS MYLLIANILL INLLIAVFNN IFIEVNAVSH QVWMFQRFTV
VMEYQQKPVL PPPLIALCHC YSLLRYAIRK AKGLQESRDN GLKLFLEKED MERLYDFEEE
CVEGYFREQE ILLQQSTEER IKNTDERVDH MAQKIEDINQ KENIQSAAVQ NIEFRLRKVE
ESAEQILNHL DVIHRFMSAH TLMNDTQGST GNVSGNVPPG GMTAGMIMDH RTRTISESDS
YILPPPTTQR KKFNRSLTEV RPDAYIFDDG KHLEVRTVLE ESEAERSPDQ VSQHLERDRK
FSIRSEDSEM FPVGSVPKAL SPVDLPTIKP SPPPPFLNIR QDTASTESKD TLTPLEGADD
RTLVGDETLD DMVEPNYEGL RHRAGRRRNS SMCGPGPNVA TNGAGGGQPT SGTLAAGSSG
GIGGRRNSES ASGGGFDINK SQTSLYQLGF SKRQHSITQS EPDSGNDQPV QRTVPKGRHL
LLLAHTEYTS ITDELESVCH MIASPTSSLR EDRTKNVNEL TNPEFAALIE KQHLKECEDS
DYMMMEKLFQ TRCSLEDSDE YFDDTEPEDH GPRKMLRRET AIELPVTPSK SNIVSLADSS
LGNEEFAMKN ERQPASNRNS LRDSKNSPLS LSSQNSPRNS QYMQSSFLNP TVCDGASRLY
KKSCESLQKN SSTDTEYSLQ PYRFIKQSSN ETNSSFNIDN SSITNDLSID GETSLNSTVI
EMVSAPSIAA AVAAAASDGE RAGFQTKRTS SLGSSSTAAE MRPGLLKCGK DKGGKDASGG
GSIPEGLERS GPSGAVMVPS KPPRSARFTD SLCVLGPKSV LSRLKESSST STEEVPQRDA
SAPIPCISTN LVQDEIAKLS SNIKSSTDED TEPPFNETMC
//
