ID A0A182M0L4_9DIPT Unreviewed; 1701 AA.
AC A0A182M0L4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA006547-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA006547-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA006547-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCM01000338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182M0L4; -.
DR EnsemblMetazoa; ACUA006547-RA; ACUA006547-PA; ACUA006547.
DR VEuPathDB; VectorBase:ACUA006547; -.
DR OrthoDB; 2880940at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR CDD; cd06611; STKc_SLK_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR022165; PKK.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR46538; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46538:SF3; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF12474; PKK; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 37..295
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 320..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1020..1106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1295..1344
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 336..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 66
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1701 AA; 188574 MW; 9717C41596876E6C CRC64;
MSFLNNLKKV FHLGSGEAKK KRIFNNIRMD TDPADFWDMI GELGDGAFGK VYKAQNRDTK
QLAAAKMCTL EDEENLSDHM VEIDILSEIK HPNIVGLYEA FSIDDKLWML IEYCDGGALD
SIMVELEKPL TEAQIAYVCK HMCAGLNHLH KNKVIHRDLK AGNVLLTMDG GVKLADFGVS
AKNKHTMQKH DTFIGTPYWM APELVLCETF RDNPYDFKVD IWSLGITLIE FAQMEPPNSE
MSPMRVLLKI QKSEPPKLDQ PSKWTKHFND FLARALVKDP QQRPSTDVLM GLPFISGNLD
SKPIKDLLLE YKADVVEEEL VDEEAEEPRN SALPLDLDDD SSSLQSQETD KLPDTPTSLS
KSSRDSKEST PVPATEDHSS KPKIGPIPTP IGAAGPPGTT PLEKTPGSVD TKSEMKKSQP
APPIVPAAAS PISGDVSAQP MIKSSSSSSN ISGGAVNVPT PVLPVPKEII PEGVKMITST
STPSAVRNQL PHHATLMNSS SSSSTTSITI NDATVLSDPS NSLASNVAQV TVVTSHPPVI
IDNSIPLPPT AAAAVASSGT SSSASSTKSF GSSQQRRSRV ISPPGTGAHD EVIIVSNELN
KTHVNESSTD DDFQSLDSLE NVSPRHHPIR TPSQSAGGRA IARKLDESEV LIVSSGFDDR
REVLLVDDTN AGSPDRDVDA YGDGDLFNAS GNNLLNNSSK LLLDTSHVSV VTVGEEEIKV
KDSSQHHPQL INNPHTSPHH YHHDSTSDLS NFHESREDVS IIVNKRKIEK SRISPDSSVG
SLEGGGSIRS ASTPIHQNHH PHQHGGAAGV MVAGNHHQRT GSIGTVPVTK HLHDRSDAES
IATTTSHDSR EHAAVDLEEE VTLRRKPVSS LELEDGKGSS SVGGTLSSGS STLVSTAGDN
SIATTTAGTP GVAGTAVAST GGTAAAGGNG TAGIKQKANR NFTKEELHLQ NLKKKTRKRT
RKFEIDGVQV TTTTSKVIYS DEDNNKLYDD HLFRKQELRE LKMLQKQEKK QFYDLQGKEA
IAKEQQEKKF EQERLQLERT FEGDMDVLAR QHRQTVEKFE QQQEAELRNT SKKIRAEQER
DLKLFRDSLK QEIRLLKQEV DLLPKEKRKD EFRKRKTQME FEHEEREKSF LSSLSENHEL
ALRRISEIYR EKLSATDKGY LQQKQTAMRT REAMLWELEE KHIHDKHQLA KRHVKDICFM
QRHQMIIRHE KELDQIKRMI TRKEEELLKR QTIERRALPK RIRAERKARD MMFRESLRIS
MTTDPEVERD KLKKFQEQEK KRYNQEQLRF ETKHSKQLEE LRATSEGSIR ELEQLQNEKR
KQLLEHETAK LRECDEALQK ELREWKAQLM PRKQAIEKHL SRMVDEYEDH WGPVDRREFD
GDFTVPPELR NRTNSLNTLS LRLLNITRSR TFLTLPTMAN GGVAGGGVYG GSGNGGNSNR
NSIHSSVPDL SRSMPNTPNS GHKLSLASSY DSVLEENEGE NQPPTMDVGR NGGGRGSSYQ
HQSAIKYIHT NDPVVSGNVH VRRKSEDMLS GKSRSTRVPI KSFLYSNTSN RYEYGGSSAY
YGGDYGGSRG SSNGPMAYYS DSKDRVVSIR VNNQAINRKP ANVFEGMTNR SNIPQSHTSS
GGTMPRRTSA GWGPSRLGEN TFTTASDANI NRLTTFSSAR GGLPLPTANG SSGRNTTNPG
LKLSPSTPVL LAPSKDDDTV V
//
