ID   A0A182M0M1_9DIPT        Unreviewed;      1505 AA.
AC   A0A182M0M1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=S1 motif domain-containing protein {ECO:0000259|PROSITE:PS50126};
OS   Anopheles culicifacies.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; culicifacies species complex.
OX   NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA006557-PA, ECO:0000313|Proteomes:UP000075883};
RN   [1] {ECO:0000313|Proteomes:UP000075883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles culicifacies species A.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACUA006557-PA}
RP   IDENTIFICATION.
RC   STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA006557-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
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DR   EMBL; AXCM01001019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 139723.A0A182M0M1; -.
DR   EnsemblMetazoa; ACUA006557-RA; ACUA006557-PA; ACUA006557.
DR   VEuPathDB; VectorBase:ACUA006557; -.
DR   OrthoDB; 167902at2759; -.
DR   Proteomes; UP000075883; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR045209; Rrp5.
DR   InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR008847; Suf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR   PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR   Pfam; PF05843; Suf; 1.
DR   SMART; SM00386; HAT; 5.
DR   SMART; SM00316; S1; 6.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          83..164
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          970..1048
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1142..1168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        993..1007
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1009..1041
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1505 AA;  170290 MW;  994A4748AA9ADF6E CRC64;
     MVGVEPAFPR GNKVQKRGLT NRVTKRKFSP KNYGATVLPE EKALRLRPKE RREVMLSEKE
     AEITMAQQAF DATNLSVATM REGMLVLACV KRIAKAHIEL LLPGCISGIV PISMISDAYS
     LRLKDMINTG STNCPTLNDL YRVGDLVYVT LLSKESSRLT FSLKPNDLHK SYVTSQLVPG
     LVLSATIVRK EDHGYSMDIG VRNVRGFLSD ESLGQNRDDV GRNLVCSIES VSRLDSNPTV
     LLKAFDPEAP WVLNMEDADM ETIVPGCRMM FTVGEQVDHG LRGMLFEDMV PAYVNENMLT
     KPTSRPDEYS MFKKIPATLL YVMPVTKQVF VSLKPYSKNR VEMNVNNGPG TIIEKAYVKA
     VKDAGVWFQF GNKCRALLRW KTIMGETAGN VDKSVVMEKF QVGMTCKLAI MHYNPLEDTY
     IVSNKSTFFD EEIRSSEDIV IGNLYTAHVL KTIPGGAFVS VGYARGSLVK TYYDHEHPVK
     VHDKVLVRAV MRELDSPFVK FTNHPALVDE KASILHDWDQ LDATRNDQSF HGVIFKQKTD
     TVFVRFFNDI VGVIQKPRAI ANQNITLMAR LNVNTVHKFT VLGFDKATKQ LELQPVSTAE
     KIQSASRLVK ARISCVHAAG VDILTNDGQN GTIPSECLSE FGEHNSLYMR LLREGQSVMA
     IQTNPDTYSM RLISYFRTHP RQIESVQRGA LLKGSCTNVN GVLYITPLLT NFSKQIEVKT
     KENRGTVQDG SIMMMRVLNV KKSPNSRYDL DVSTALLDVC ENGTKDVFNF TAEYLKDVKK
     LIKRYQVEKF GFANYNLGDL VNCVVESIVP SSNQVTVEVH SKRKKSKNVT KGIATAILPS
     HPATSYTVGQ KVPGRVVWID VERKLLHVCL DQPLVKSILP NSSLTGRKYT PDAQSCWVLY
     ANNYVQVCCL QANPPNPLVI VPVKYHYNDL MEKVNNTSKS VTVRLVRNLD DMIFGINSKE
     MKLYENMKDD RDGEGQLEGM TNQNAEEDAN SSYEIMDYND DDNDNSNEEP LNGWRVRTPV
     TMSTSNGKKK KNGSTSDLSK KGQGEPKLKR MIAVEAKESV SQMQLPLKKK APLKEDPETA
     TAAKRTKKTI LKKDKKSIVE LHSNGANAKK SNLKKKKMPL VLEQLDGACD FYLHQLDGTE
     DITPSSNNKM GARKRKHTTE GNGLPGAVNF WDSTPVYKRT VSDSSDDETH SSDDEQCETV
     GKMRITAKER FEAMKKEEER LRKIEDELAN PSADPHTPDQ FDRLVLAQPN NSMLWIRYMA
     FHMESAELDK ARAVGRKALK AIHFREETDR LNVWMALLNL EIRYETVDSF KEVLQEAVQY
     NDAFKVYSRA VDILIDCQKH AEVQEMLELL LKKFRKQNDM WFLVADAWYR IGQGSKVKPL
     LSQALKSLPA REHIGMIVKF AFLHNRNENR DEAHLLFEQI LTSYPKRTDI WSQYIDMLVK
     DNLVGNARQI LERAIMQRLP MKNMKTLYTK YVNFEEKHGD RDSVRRVKQM ATDYVQAQLN
     NAGIN
//