ID A0A182M4V6_9DIPT Unreviewed; 647 AA.
AC A0A182M4V6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Domon domain of stromal cell-derived receptor 2 {ECO:0008006|Google:ProtNLM};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA009521-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA009521-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA009521-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR EMBL; AXCM01004801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182M4V6; -.
DR STRING; 139723.A0A182M4V6; -.
DR EnsemblMetazoa; ACUA009521-RA; ACUA009521-PA; ACUA009521.
DR VEuPathDB; VectorBase:ACUA009521; -.
DR OrthoDB; 3027001at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF38; FERRIC-CHELATE REDUCTASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR SMART; SM00664; DoH; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..647
FT /note="Domon domain of stromal cell-derived receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008127968"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..189
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 237..358
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 355..562
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
FT REGION 186..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 70221 MW; 5467892DE37F3EBB CRC64;
MLAVRNNPSA MLPLLCLALV LSTLLPSHGL PNGAPTSVCD NMLPFHGGGI PALTTKTPFL
ITPQSSVIGS GQTLKIDIES FPANIVFKGY MIQARAATGP NNIVGRFVST DAAAIKLIDC
QAEGDTATHT STSPKQELTL EWIAPDNFVG DVIFNATIAQ DYDKFWVGIP SEPVRVVASS
TTVAPGTAST KRTTTTTTVP PYRPQQTAAP VAADPIYDDC GQSKGCFGFP EGCVDSKNCR
AVATIAVLGA RYVFEMKAGY NNPAYVALGL SDDAKMGEDS VIECVPEQGT VNAYASWTTV
GPYGSTRLGV PQNIFQVIEK SYNDGVIYCK VERNAVSMVK GKKFDLVNDK FHLLIAAGSS
VESTNVNYHD IGRHVSGSPQ SLAEVGPVQG TSKLLLRLHG AFMITAWIGT ASLGILIARY
FRQTWVGSQM CGKDQWFAWH RFLMVVTWAL TVAGIVVIFV EIGGWSQVRN PHAILGMVTT
VLCFLQPIGA FFRPHPGSSK RTIFNWLHWL GGNLAHVIAI VAIFFAVQLQ KAELPEWMDF
LLVAFVAFHV FMHLIFSIFS WIQIGGCVSE RRSGQRVTSF PMADMTPSRN SMSSSERKQD
AAFSGFRKSM LFLYILIVLG LVIAMVVIVV LAPIEAAYNS IKEQIMN
//