ID   A0A182M636_9DIPT        Unreviewed;       735 AA.
AC   A0A182M636;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Anopheles culicifacies.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; culicifacies species complex.
OX   NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA010401-PA, ECO:0000313|Proteomes:UP000075883};
RN   [1] {ECO:0000313|Proteomes:UP000075883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles culicifacies species A.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACUA010401-PA}
RP   IDENTIFICATION.
RC   STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA010401-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   EMBL; AXCM01006815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182M636; -.
DR   STRING; 139723.A0A182M636; -.
DR   EnsemblMetazoa; ACUA010401-RA; ACUA010401-PA; ACUA010401.
DR   VEuPathDB; VectorBase:ACUA010401; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000075883; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF74; ANOCTAMIN; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        283..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        313..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        384..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        421..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        469..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        582..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        633..657
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        672..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          272..707
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   735 AA;  85806 MW;  3809CF79189B2963 CRC64;
     MEDIKENLIP NLHFAENDEE ELAEEIGLPR RSTIPSLLQR NSQINLLEQI DDKVHQNAMN
     EIRRRQGTVR FASTKTTRQD KARPPDDQTP FGESLMVLEF GESAPFEAIQ WIMEKIRGRR
     VDGGLELLVR KEPLSKDSQT IIFHISATHM KLLEIADDMG FMKRTKTGII RNFNVACLDE
     FFYDEGMALE DILTPADRQI IIKHALESIK AADDEHRIPG TKIILYHGQS IIQAAQSAEL
     ISNLYSLHDK RTLKELRHRW IKPTRVQPID EIRDYFGESV GMYFSFLGFY TYALVVPTVF
     GFLQLGLSEE TETVPFFCVF YVVWMKVFLE LWKRKSSSHA YRWGTITMTN LDEPRPGYYG
     KLARDPITGK WTPQYPKWKT YVQMYCVTAP IILLCMGIAA FVTIFQFYVE AYLAELFGPD
     AYILYLPSVV NAIYIAVSTL AYDRLATYLT DKENHRTQSQ YERHRVNKLI VLEFVNNFLC
     LFYIAFILQD MKMLKTQLMM QLIVLQFLQN VFENLYPYLK KKVGLKIVRL FVKSNYEKLK
     EAHESYDEMG LRSLDDDDPR VIQNRKETIL EEYNTYDDYL ELYIQFGYVV LFSSVAPLTA
     FWAILNNVIE IRLDAYKLCS FFKRPFARRT KNIGAWQLAF ETLAVISILT NCGILYLSPH
     MRELGAGFTR ESYTLTFLVI EHVLLGLTWF IYKAIPDTPH WVRVALAKAE HESRQALKRE
     VLQEKVQQQN IVRWR
//