ID   A0A182M8X0_9DIPT        Unreviewed;       152 AA.
AC   A0A182M8X0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   RecName: Full=MD-2-related lipid-recognition domain-containing protein {ECO:0000259|SMART:SM00737};
OS   Anopheles culicifacies.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; culicifacies species complex.
OX   NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA012368-PA, ECO:0000313|Proteomes:UP000075883};
RN   [1] {ECO:0000313|Proteomes:UP000075883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles culicifacies species A.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACUA012368-PA}
RP   IDENTIFICATION.
RC   STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA012368-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NPC2 family.
CC       {ECO:0000256|ARBA:ARBA00006370}.
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DR   EMBL; AXCM01009834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182M8X0; -.
DR   STRING; 139723.A0A182M8X0; -.
DR   EnsemblMetazoa; ACUA012368-RA; ACUA012368-PA; ACUA012368.
DR   VEuPathDB; VectorBase:ACUA012368; -.
DR   OrthoDB; 3431986at2759; -.
DR   Proteomes; UP000075883; Unassembled WGS sequence.
DR   GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IEA:InterPro.
DR   Gene3D; 2.60.40.770; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR   PANTHER; PTHR11306:SF36; NIEMANN-PICK TYPE C-2C-RELATED; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..152
FT                   /note="MD-2-related lipid-recognition domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008128077"
FT   DOMAIN          21..148
FT                   /note="MD-2-related lipid-recognition"
FT                   /evidence="ECO:0000259|SMART:SM00737"
SQ   SEQUENCE   152 AA;  15655 MW;  344567CF59CADC39 CRC64;
     MYKFLLIVAL LPAIAFGQTP FRPCRGGGPT PASVNIEGCT ALPCTIVSGS PLIAHATGIR
     TSVATPTVEA HIIARVLGLD VGFRIPEDLR DACAVGISGA TCPLSVGQEF DYTLNYAMTL
     PLTGITAQVE VGLTAADGSL ITCIEIDAQI VA
//