ID   A0A182MDF9_9DIPT        Unreviewed;       882 AA.
AC   A0A182MDF9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS   Anopheles culicifacies.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; culicifacies species complex.
OX   NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA015587-PA, ECO:0000313|Proteomes:UP000075883};
RN   [1] {ECO:0000313|Proteomes:UP000075883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles culicifacies species A.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACUA015587-PA}
RP   IDENTIFICATION.
RC   STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA015587-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR   EMBL; AXCM01000135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182MDF9; -.
DR   STRING; 139723.A0A182MDF9; -.
DR   EnsemblMetazoa; ACUA015587-RA; ACUA015587-PA; ACUA015587.
DR   VEuPathDB; VectorBase:ACUA015587; -.
DR   OrthoDB; 124901at2759; -.
DR   Proteomes; UP000075883; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
FT   DOMAIN          22..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          410..448
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   882 AA;  98142 MW;  9C27D109A8532459 CRC64;
     MMHIVQILEK TVSPDRDELL AAKNFLEQAA SSNLPDFLRA LSDVLVYPGN STVARMAAGL
     QLKNHLTSKD QAIKQQYQDR WRSFPEDVKE YIRKNILGTL GTEESRPSSA AQCVAYVAVA
     DLPAHQWPDL MQKLVDNVVN EKSTEALRES TLEAIGYICQ DISSEILENQ SNQILTAIIH
     GMRKSEPSNH VRLAATNALH NSLEFTKANF EETAERNYIM EVVCEATQST DTQICVAALQ
     CLVRILTLYY QHMEAYMAQA LFPITLEAMK SDNEQIALQG IEFWSNVSDE EIDLAIEAQE
     AADTGRLPNR VSKYYARGAL QFLVPVLMEK LTHQEEFDDE DDWNPAKSAG VCLMLLATCC
     GEEIVPHVLP FVNANIKSTN WRFRDAAVMV FGSILSALET DRLKPMLEQA MPTLIELMYD
     ESVIVRDTCA WTFGRICEVI PEVAIKEMYL EPLLKALLDG LKAEPRVATN VCWAFTGLSD
     AAYEAVNIDD DPPQTYCLSK YFDFIITSLL EATDRPDGGQ GNLRSSAYEA LMEMVKNSPL
     DCYVTVQRTT MVILERINHV LQMESHISSH SDRHQFNDLQ SLLCASLQSV LRKVDAKDAP
     QISDAIMVAL LTMFSSSSGK VCGVQEDALM AVSTLVDLLG EDFIKYMDAF KEYLYMGLKS
     HQEYQVCCTA VGLAGDICRG LKSKILPYCD DIMTLLLQNL SNPNLHRSVK PQILTVFGDM
     ALGIGPDFKK YLNVVLPMLA AATQVQIEQH DYDMIDYLNE LRESVLEAYT GIVQGLKGSG
     TTPLEDVTAL LPQVPFIISY IISIAKDSEL SDGNIAIAAG LIGDMCGAFG PMMLQFVEDS
     SITELLNDGK NSRTARTKTL ATWALKEIKR LKNLPVSTSW TS
//