ID A0A182MGB2_9DIPT Unreviewed; 606 AA.
AC A0A182MGB2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA017617-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA017617-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA017617-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCM01004303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182MGB2; -.
DR STRING; 139723.A0A182MGB2; -.
DR EnsemblMetazoa; ACUA017617-RA; ACUA017617-PA; ACUA017617.
DR VEuPathDB; VectorBase:ACUA017617; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07595; BAR_RhoGAP_Rich-like; 1.
DR CDD; cd04386; RhoGAP_nadrin; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 251..443
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 67752 MW; E8A6AD5AE491DBD7 CRC64;
MDNGRIAKSA STARGTVSNK AEKNADGLQA IEREVERYKE FLQNLNKRIA LNVSAGQPQD
AVAREKRCKK VPEFQLGQLM EESVKDLPAG LLKEVLDTCA RVEKRIATEI VNNEVNVENS
VSKNLNDIIE RHLSTIQKQK RVVTKCHQEH EASRQKYDSA QRNSDQVGNQ AKITQLKDDQ
EELHTKLEKE RDLYESYMYE LLAEEENIAL FVKEYVKHQE LYFTSVLREI QHTMRSMDGM
FRRNNKQIFN TPLRDHLKAT DRKIAYVIEL CVCCLLEKGL YEEGLLRVGC ASSKLRRMIS
AINANYVSPP LADKYCDPHV VAGVLKKYLR SLPEPLLTLE FYADFVQAAQ KPSEAQRKAA
ILDIVNQLPR ENYDNLRYLT KFLSYLAEKN QENKMSPQNI AIVMSPNLLW SPNENENYMD
QVNSTATVNT IVEALVGDWA FFFDGEVNFY ATMTRDALFP DNGGFPFDKD QHDQGTGTGL
SKPKQSTKRK DNPLPASAVS HQQVEAVGSS IPQGTPPLAM MESTGSLGSD VQSPVNPLPP
PASTTTPIGT VASTNSTSSV TSTTTTTSLQ HVPQSPRGID PKIKRPQVPA PPPPVGRPKS
SDSTDL
//
