ID A0A182MGC2_9DIPT Unreviewed; 1762 AA.
AC A0A182MGC2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Protein eyes shut {ECO:0008006|Google:ProtNLM};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA017639-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA017639-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA017639-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AXCM01000141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182MGC2; -.
DR EnsemblMetazoa; ACUA017639-RA; ACUA017639-PA; ACUA017639.
DR VEuPathDB; VectorBase:ACUA017639; -.
DR OrthoDB; 101939at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 7.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}.
FT DOMAIN 6..42
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 44..80
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 82..118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 120..158
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 160..196
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 198..234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 236..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..606
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 624..832
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 882..919
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 926..1114
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1115..1151
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1153..1191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1271..1456
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1452..1489
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1490..1523
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1529..1748
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 352..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 10..20
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 32..41
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 70..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 108..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 148..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 186..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 224..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 265..274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 596..605
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 909..918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1141..1150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1181..1190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1479..1488
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1513..1522
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1762 AA; 192756 MW; FABE6D526FA0DF35 CRC64;
MHLTEAGFAC LSNPCVYGVC IDDLNSTYSC YCIDGYTGVH CQTNWDECWS NPCLNGGICI
DGVASYNCTC PDGFLGLNCE ENFNECQSNP CQNGGLCHDK DNAFYCTCAL GYEGEFCELD
IAVCDTGDRC HNGAACIEGP GLEFSCRCTE GYEGRLCDAE INECASAPCQ NGAICIDKFA
SYICACPMGF GGMNCEEEIL VCASSPCANQ ALCLMEEDSP TCYCVPDFHG ERCELQYDEC
QLGPEPRCVN GATCVDGVDE YFCTCAPNFT GENCECLILD DDGQIEMDCN YTAPIASTSG
DMTDSSFFTS TMESFPFSTD GIWKATDASL ERTTSYSLFT YTAGPTVVSE FTDPSVERPY
NGTSVQVSPN YSASDSGSDQ YSTTSLSESV TDGATVSRGT VPPDQEKDTK STVESGDTTP
PDTMSENVPT VSGVEDKPSS VPDITHDGTL TDVSSTDYTT VKSSSKQPSI DYGSGSSVSE
FPTTPMDALL TTSDHPSVST LTPELSSFFT ESPTNRSVPT FHGEDQVTDT PSFTTAPTLF
TSPDATTRSS FGTTSGASIV PPLTTRSPEV IQQCDDTVCA NGGTCAMTPN GIRCHCDFRY
AGPFCDMPVS IQNAAFSKES FLRHIIYRRN SSSDPSIQSV DTLKQLASMS VRFKAKLTSR
EGLIVLATAE GDDGNHYVAL FLHKGLLQFQ FSCGLQTMLL SEIEGTVNNG YELNVKVQLN
FNDRYSHCNA SLHVNETLAM SGEQPTWLGN VLRTRPQKEG SDGVAALASI KQSWLHLGGR
PIKTMYTLSH NISRYHGFTG CVYDLEINGA PVAIFDNAED AYKIYECTSL ACLSSPCRNG
AICVEADGYG LAGRYSPSVT QPDTVSAWSC KCAFGYMGKT CERSVCDNNP CRFGGTCVTF
PESGYLCLCP YGKHGHFCEH DLDILQPSFF GSIKGISSYV AYPIAFPVED RFEFSFKIIP
TTTAQISLLA FIGQPYDHHD QSDHFSVSFI QGFILVTWNL GSGPRRIFTQ QPIQVQSSRP
TTIHAGRNGR TAWLSIDGKV NISGNSPGNS RKLNVSPQLF IGGHEGVNFS SLPHDLPLHS
GFQGCLFDIR LVAGPIHIPL QHIGGMRGRS VGQCGTKECH RHACQNNGAC LQHGSTFTCI
CQEDWNGILC SQKVNPCDES VSKCASDSTC FPLVSGYECD CPYGKVGKRC ESNLKYLSDV
SFSGRRSYVA LRWPNVGTGD WIAAYRENEV RYEKIVQHSH IIPHNHSILL KSIRELDKIN
DVLKVLPEAN DTELYAGHSV IPRSENYRQL RVRQLTIELQ VRPLSEKGLI LFIRTFDSNA
QEQGFISISL QGGVVEYRIS SARTQTAVVR SNHVLATGEW HFIRIVKYGK RLTLWVEGKS
TSIIGSVREE YVSLTKKLYL GGLPDLSTLP YDAISGYPVP FRGCIRHVNL NGTRITLNDS
SIVASRNIND CDGTPCGGDI CAHGGLCWLD EHSQPRCKCP EYSKGANCEI QESCEVVQCR
NNGQCLKNGR CSCGVGWTGH YCEIATTKYS SLGFNDRSYI LIPSQKIKMK DKRNDDSTSM
AGKLPFGLQI SFNISTLEDG MLAWTTDETG RYFGIGIRDG FLVVVSNMLK EDPTNVASGA
TGPWKAFVAD GDWHNVLLET KSHQLRLFVD GYELLAGTLI PNSRSQAYDR PVLSEEITYL
GGFPDANVYN RTMGNFATSF NGCIQHILLG NQLDELDYVD YDGANINESQ TRIRFVSIVI
PLNDDPFCST NYKKEEMIFE SF
//
