ID A0A182MGU4_9DIPT Unreviewed; 1384 AA.
AC A0A182MGU4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Regulator of G-protein signaling {ECO:0008006|Google:ProtNLM};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA017947-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA017947-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA017947-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCM01002615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182MGU4; -.
DR EnsemblMetazoa; ACUA017947-RA; ACUA017947-PA; ACUA017947.
DR VEuPathDB; VectorBase:ACUA017947; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01817; RBD1_RGS12_like; 1.
DR CDD; cd17067; RBD2_RGS12_like; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR PANTHER; PTHR45945:SF3; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 281..394
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 543..613
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 614..685
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1217
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1384 AA; 146742 MW; F075B2FAE5240E28 CRC64;
MYKHYGEQAS ANAPLQLDRN NNSSINNGAN GKETRDGNHR PPAATFQRSG STLRRNVERK
RFFATPACTA PAPVVVPVDT DLPQDGDCGE RQQTDGEQQR ANMLLTSHDH VGFKMMGFIK
EDEIYGSSIG NGGGTESAQH SPTINGSTGR GRKAIIPEIN VIAPPAAETE QDGKQINHNA
SPFRRWGQSS LRSRSTEHRT PTNGSARRPS SLAASESDVY TKSIDDDYSS TKSGYNPYTG
GVDTLSTEST TVTTGGGTLG TAGSGSTANA GPTGVASWGT SFEKLLEDAG GLHTFSEFLK
KEFSAENIYF WTACERYRQL TEREERAREA QAIFARHLES GCSDPVNVDS IARNIALENL
PQAETTLFAA AQKQIFNLMK FDSYQRFIKS DMYRVCQEAE AKGQVLPYPG EQLDPMLRTS
STMVTSNGAN AAGVTKLKKS LSNAEDRRRK SLLPWHRKTR CKSKDRGDSD ASKKDNGKGG
SAGGGNGEKA PGMATGGGGS SSNTLKLLST NSTSDIHSSR SSLASFDAAI GGKSYDPDDS
RNTLCRVILS NGATTVVQTR SNETIKELVE RLLEKRGIVY NAYEAFLAGG TKPLDLDGPS
VSLSGKEVNI DQRVVFKLNL PNRKMISVKS KATKPLADVL RPILYKYNYE LDQMKVEVHS
AVDVTLDMTQ PVTTVDGLYL YIRSANESIG GPVHPELGRP LAGARPVINT ATHQQIVHHF
QQQQQQLLNS QPTSVTNQQP HTFVIPTANP PSYAVATNTK SQQIFGGGTA ASATTCNSKT
NQTRAKEQME PVKDDQQGTA SARGQQELNT LDEITNKVFN ELMNGKTAGN GTVGKGPPDV
DCTSDTSSTR RDRFRRRGSN AAPSESGRGA KSKKCSTGGS EDGGESVNNL GIKKPIIAKL
KAGVKLQIPT RSQNDELLEG LKRAQRSRLE DQRGTEINFE LPDFLKDKEN FSTASATPLG
NSATGSINAA APTTTTAGPS KLTRSKPARR SEATTPTSEF VGGSLQQINK PQPAPRLSIT
GQSGRPNLSG PGSPVQTAVS DSHLNLSTQC NASPLPQDDP FHVHSSTGGG SQSETSYADT
TLVFTHARPF NGQPSVAATP RTISSNSASH HHNAGDHSSD SSTAAEGDLT TIGCCEHHPH
EISPDSSPPS HGNHLHPLHY HSAGASATNG NGAATCNSAA GNPYPMVQYP SHHHHHHLHP
HHHPHGQHYH HYHHHAGTRY QTATPVSNGL DGQTGASTAD SQKGPPPLPP KPKILPMKPS
NWGHPVAASY APGPLGANGG NDGGHGGLTL STNGTGGNSF SGNSVATVSG GSNSSSTLSN
NHPTGSNNSG NGTTAGNSNG TANTSAHIDN ANTTISSASS TSAISVAVAQ ARNVYFDQGN
SSFV
//
