ID A0A182MNH6_9DIPT Unreviewed; 674 AA.
AC A0A182MNH6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ACUA022514-PA};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA022514-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA022514-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA022514-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; AXCM01001130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182MNH6; -.
DR STRING; 139723.A0A182MNH6; -.
DR EnsemblMetazoa; ACUA022514-RA; ACUA022514-PA; ACUA022514.
DR VEuPathDB; VectorBase:ACUA022514; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15035; 7tmF_FZD5_FZD8-like; 1.
DR CDD; cd07456; CRD_FZ5_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF126; FRIZZLED-2; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..674
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008128574"
FT TRANSMEM 301..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..170
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 299..594
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 165..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 54..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 62..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 99..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 126..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 130..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 674 AA; 73823 MW; 4F1AF188BC71AA10 CRC64;
MQSALRHTRG IRCFICVLPM LLLLISGKVD GSYHSGVSPM PHVPAVPKDP NSRCEEITIP
MCRGIGYNLT SFPNEMNHET QEEAGLEVHQ FWPLVEIKCS PDLKFFLCSM YTPICIEDYH
KPLPVCRSVC ERARAGCAPI MESYSFNWPE RMACENLPVS GDSDNLCMEM PSEEEHGERG
TGGASAGGSG GSGHSGKPTR KSHGGSGGQS SGAGGSQQNN KCKGKNSKNC QNPPGERTKE
CMCRCREPLV TLGRESTTTL LHHHGSLSNN QSVERVGDVQ NCAIPCRGAF FTQEEKDFAG
IWIALWSGLC GISTLMTLTT FLIDTERFKY PERPIVFLSA CYFIVSCGYL TRIFLGHDEI
ACDGKSIKYP STGQSSCTMI FIMIYFFGMA SSIWWVILSF TWFLAAGLKW GNEAISKHSQ
YFHLAAWLIP TVQTVSVLLR PAVDGDPVAG ICYVGNTSVE NLKNFVLAPL FMYLVVGTTF
LMAGFVSLFR IRSVIKQQGG IGAGSKADKL EKLMIRIGIF SVLYTVPATI VIGCHLYEAS
YFEDWMTGLT CPCKVAPGLR QKPLYSVLML KYFMALAVGI TSGVWIWSGK TVDSWRRLWR
RLFGSPDPTG AGQVLIKPRP PLPQPYATSG IGVPGSAAAS LLATPYTQTV GSVASTSHHH
LHHHVLKQAP LSHV
//
