ID A0A182MQB5_9DIPT Unreviewed; 1512 AA.
AC A0A182MQB5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA023729-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA023729-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA023729-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; AXCM01000634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182MQB5; -.
DR EnsemblMetazoa; ACUA023729-RA; ACUA023729-PA; ACUA023729.
DR VEuPathDB; VectorBase:ACUA023729; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1056..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1149..1173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1308..1342
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 441..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 384
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 819
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1512 AA; 171681 MW; 75FC0A418B36222A CRC64;
MDDPHPCGED GFHCDTISPE MVCRYYWEGP NFGITNFDNF GLSMLTVFQC VTLEGWTDML
YYIEDAMGSS WQWVYFISMV ILGAFFVMNL ILGVLSGEFS KERTKAKNRG DFQKLREKQQ
IEEDLRGYLD WITQAEDIDP DNDASGMPEG KMKNTIELDS SDNVGEDGEV QHESWFARKR
KSIDRVNRRL RRACRKAVKS QAFYWLIIIL VFLNTGVLAT EHYRQPPWLD DFQEYTNMFF
VALFTMEMLL KMYSLGFQGY FVSLFNRFDC FVVIGSIGEM ILTSTQIMPP LGVSVLRCVR
LLRVFKVTKY WQSLSNLVAS LLNSIQSIAS LLLLLFLFIV IFALLGMQVF GGKFNFNSSI
DKPRSNFDSF VQSLLTVFQI LTGEDWNAVM YDGIQAYGGV ASLGIIASIY FIILFICDIL
LNVFLAIAVD NLADADSLTT VEKEEGENAE GEEEKLSHEP TPTEHGDDGF MDHDKDNLDS
DNDPMNISDE YDGHDSDSKT PVAEDDEGYE EQDTPDSQDG GLKVARPRRM SELNVINTIV
PIPDGSSFFI LSKTNRFRIF CHWLCNHSTF GNIILVCIMF SSAMLAAEDP LNANSERNQI
LNYFDYFFTS VFTIELLLKL VSYGFLFHDG AFCRSAFNLL DLLVVCVSLI SMFFSSGAIS
VIKILRVLRV LRPLRAINRA KGLKHVVQCV IVAVKTIGNI VLVTCLLQFM FAVIGVQLYK
YVVKCVIVAI KTIGNIMLVT YLLQFMFAVI GVQLFKGKFF SCSDGSKMQE SECHGTYLVY
EDGNVDKPVS KERYWSRNRF HFDDVSKAML TLFTVSTFEG WPGLLYVSID SHEEDSGPIH
NFRPIVAAYY IIYIIIIAFF MVNIFVGFVI VTFQNEGEQE YKNCDLDKNQ RNCIEFALKA
KPIRRYIPKH RIQYKVWWFV TSQPFEYMIF ILIMINTITL SMKFYRQPEI YTEVLDLLNL
IFTAVFALEF VFKLAAFRFK NYFGDAWNVF DFIIVLGSFI DIVYSEVNIS KGMKGGSSII
SINFFRLFRV MRLVKLLARG EGIRTLLWTF IKSFQALPYV ALLIVMLFFI YAVIGMQVFG
KIAMDDDTSI HRNNNFQTFP QAVLVLFRSA TGEAWQDIML DCSARPGEVN CDSKSDDAGS
PEGCGSNIAF PYFISFYVLC SFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFVRLWSE
YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL CPHRVACKRL VSMNMPLNSD GTVLFNATLF
AVVRTSLKIK TEGNIDDANA ELRNTIKQIW KRTNPKLLDQ VVPPPGVDDE VTVGKFYATF
LIQDYFRRFK KRKENDNKLN SDQNKRRTMT LQAGLRTLHE AGPELKRAIS GNLEEIGDDN
PEPSHRRNHT LFGNVWSSIR RPGPFGSKQK WSSTNNKMSA TSMAASAAMH TVLSGPNDGS
SQTDKKPKLN CVNSSNPYNH VAESILHAVH DEPLGRSFGN GFGAGSAGNP GDIPLRPLVL
DDSSNLKRVT AK
//
