ID A0A182MR49_9DIPT Unreviewed; 604 AA.
AC A0A182MR49;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=GRAM domain-containing protein {ECO:0000259|SMART:SM00568};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA024272-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA024272-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA024272-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCM01000346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182MR49; -.
DR STRING; 139723.A0A182MR49; -.
DR EnsemblMetazoa; ACUA024272-RA; ACUA024272-PA; ACUA024272.
DR VEuPathDB; VectorBase:ACUA024272; -.
DR OrthoDB; 45896at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23319:SF13; GRAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 471..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..257
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 64928 MW; 7AEBEF7F20EBE919 CRC64;
MNHGGNSNSS SMVRSSSKLG SSEASSTSSA SSSSPAAKRL YKARRIMLRK SRSANSVGLG
TRPLPLSSTI EPLSSVETPG GQPEGAAHLN VLSRSPSHST AKSDPKMPLT PAYSTPNIAT
ADDSDVSCVR LRKHSALYRS LKSLSPSARS STIRSSSPHP LKSFSSTRDT VDKPEKHHKK
KEGGISWEQK KFAQHFSQVP DEEFVLDYFS CALVGDILLQ GYLYITQNYF AFYSNVFGYV
TKLLIPTVSV LDISREKTAY MFPNAVGVKT RDDRHVFGSF LSREAAYYLM CSVWERATTP
LSDSLGSIQH TRLAPLHAEG SEGSLDEDSS CYDGNESSFH GKDEMPDLLD SGDSHEKHLN
VTEGGGTNQS SDDSTVLQKQ KKLKKELLLK SPAIVKSPAI LKVAVAAGAL EGLKGDKAIP
MLAGGLIGDG VGIGGGTIGG STARGVYGDG AGRSKLSLIK QKLRHILPSD FGIIHIGLIL
AVLLALFSCF LAYKIHALQA RLAAPPIRLG DDTDFYLDVL RWQKRLHSKS KEEAQIVLNS
NLEQIIKVRK SLETLSLLIQ DSATEGSGGV DEQGLLGAMI ADGASSVLED SGSLNQQYFH
EDAT
//
