ID A0A182MRS1_9DIPT Unreviewed; 659 AA.
AC A0A182MRS1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 03-MAY-2023, entry version 32.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA024700-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA024700-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA024700-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Early
CC endosome {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}.
CC -!- SIMILARITY: Belongs to the rabaptin family.
CC {ECO:0000256|ARBA:ARBA00006603}.
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DR EMBL; AXCM01000769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182MRS1; -.
DR STRING; 139723.A0A182MRS1; -.
DR EnsemblMetazoa; ACUA024700-RA; ACUA024700-PA; ACUA024700.
DR VEuPathDB; VectorBase:ACUA024700; -.
DR OrthoDB; 2904642at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd15739; FYVE_RABE_unchar; 1.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003914; Rabaptin.
DR InterPro; IPR018514; Rabaptin_coiled-coil.
DR InterPro; IPR015390; Rabaptin_Rab5-bd_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR31179:SF7; FYVE-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31179; RAB GTPASE-BINDING EFFECTOR PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF09311; Rab5-bind; 1.
DR Pfam; PF03528; Rabaptin; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 586..644
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 196..244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 296..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 487..549
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 76266 MW; 2F3A4DE6DE455937 CRC64;
MESEKDKAEP PTAGSSVTEV TSGTQNQSAQ KEILRMREEF NQQRARMKEL YLAKESKLQR
HVCADKIKNC SLFCSVDECK RIAAESANTR KELEEAKAQL MIMEYSREKD AEEQRNKVED
ENRTLKQLVN ETLDESSIMR ESVKQMKDEN TRLMDEIRQL KEELADNNQV SPSLAKTVQQ
AKKIILKLGA ADSSSCDNLE DSMRKAQEDA EVLRSLVVPL EEEIKSLKEK LRLAYEEIET
YTATRVQSKD GAQTSALIGM LNPAGPVQEP PSSNEPQPAQ PCEACATHEA NLARQQEEEK
KRTAAWEKSV ERLKEQIAKE AALRADLEVQ WHKKREEHKN EVQKLTEWST DTEQALEKLR
REYGQLKIAL RDELQKLTQE REHIYYKLNS LQQDNEFLSG KYIASSDALK DQEINFPQSI
EELQELVLTL HENLIVTKAG CEFAERKARS MQDEVALLQE QQRCRDREVK KAEQHFTHKE
HQLLEQLRKQ EHDFNLLESV REELERTGIE QQKQNSDLRM QIIELQACNE RLDRQNNDLR
SKMMVLQEDL ANNEAVQKDF VKLSQSLQMQ LEKIRSADTQ VRWQDDDDVD QCPNCKKEFT
VTRRKQHCRH CGTIYCQPCL SKSVPSGPNR KPARVCDVCH TLLVQDTAPY FSREPPQSP
//