ID A0A182MU04_9DIPT Unreviewed; 5374 AA.
AC A0A182MU04;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 03-MAY-2023, entry version 37.
DE RecName: Full=F-actin monooxygenase {ECO:0000256|ARBA:ARBA00012709};
DE EC=1.14.13.225 {ECO:0000256|ARBA:ARBA00012709};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA026227-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA026227-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA026227-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-
CC (R)-S-oxide-[F-actin] + NADP(+); Xref=Rhea:RHEA:51308, Rhea:RHEA-
CC COMP:12953, Rhea:RHEA-COMP:12956, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16044,
CC ChEBI:CHEBI:45764, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.14.13.225; Evidence={ECO:0000256|ARBA:ARBA00001591};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Mical family.
CC {ECO:0000256|ARBA:ARBA00008223}.
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DR EMBL; AXCM01000367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182MU04; -.
DR EnsemblMetazoa; ACUA026227-RA; ACUA026227-PA; ACUA026227.
DR VEuPathDB; VectorBase:ACUA026227; -.
DR OrthoDB; 5399346at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09439; LIM_Mical; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR022735; bMERB_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR23167:SF54; [F-ACTIN]-MONOOXYGENASE MICAL; 1.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR Pfam; PF12130; bMERB_dom; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM01203; DUF3585; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51848; BMERB; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 590..697
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1080..1144
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 5184..5317
FT /note="BMERB"
FT /evidence="ECO:0000259|PROSITE:PS51848"
FT REGION 783..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1732..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1877..1937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1980..2103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2159..2178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2213..2240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2298..2372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2620..2743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2864..2885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2936..2975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3104..3156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3221..3277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3402..3423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3458..3504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3535..3556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3670..3726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3751..3829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3946..3969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4047..4078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4159..4196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4217..4261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4421..4441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4455..4534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4592..4620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4814..4846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4868..4929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4972..5048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5183..5214
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 798..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1250
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1877..1896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1909..1930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..1995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2011..2067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2074..2103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2318..2336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2661..2730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2961..2975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3131..3156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3232..3246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3458..3484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3487..3504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3712..3726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3767..3790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3802..3829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4047..4061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4062..4078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4179..4193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4455..4498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4499..4513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4827..4841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4868..4894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4978..5019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5021..5045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5374 AA; 593160 MW; FE5C324A599ECEA6 CRC64;
MVTAVTNSHN EMANVLFYVH YVHQGQWEER WCMILFFVSL PADSSDRGGS VILLQKILTN
TDTMSEEFIV DHERAAMATE MFLHFCAATT MKQIRGLYWN MLDTIGLRPG PLNEFYPKLK
ATIRDWRAQA LFKKFDARAA HKVYSKGKAA SNTRVLIVGA GPCGLRTAID AQLLGAKVVV
VEKRDRISRN NVLHLWPFII HDLKALGAKK FYGKFCAGSI DHISIRQLQC ILLKVALLLG
VEMHEGVSFV KEIEPGDGYG WRASVSPEDH AVSHYEFDVL IGADGKRNTL EGFQRKEFRG
KLAIAITANF INKRTEAEAM VEEISGVAFI FDQPFFKALY EKTGCDLENI VYYKDDTHYF
VMTAKKHSLL HRGVIIKDLS DPAELLAPSN VDKPKLYEYA RDAANFATKY QMPNLEFAVN
HYGTPDVAVF DFTSIFAAHN SCKVTVRKNY RLLSCLVGDS LLEPFWPTGS GCARGFLSSM
DAAYAIKLFA NPKNSLLATI AQRESVYRLL GQTTPENLNR AFGAYTLDPS TRYQNLNKSS
VQIAQVKHLL DTDDLTLLEQ TFFDSNAIAS SVTPATELPV KRKRRTVDVV PLGATLLRWL
KSQLKDSGFV QELNEPAECF TNGKVLCTLI HRYRPDLVNL EELADFSAEV CNEHAFNIFE
NQLGIPRVMS GQESVTLSGV DAKVWLNYLE QICDVFRGEI PHVKHIKLDY AEFKQKQESN
VDAWAKLGRM AAVQRMAAMA SGVHPPDGDL GPKDVVPVAT SSAAFGTRAN AKNYYHPNAE
EERYKRGHGG VASPQNDTMR RMRKRRSNEK SGNIEERTRR LQEIEANRLD RQSKRREQRA
QQTHNFYKSI HMLQANTLLR ESDSAGAFED YSLYLYRQSA PEFNDRVREL ELKLRYPDRD
RGLAAAYPRG LTDGDQFSDR VRSMEQRIDG KALPVVEKKP KDLLRAIGKI DSSDWNVKEI
ERKIEQSKKT TDIGKSRERV PNWNREQFLA RQNRLMQPQD DEKYKEIDSS LKAIDKQLKE
GHNLDLGERG KNKVALIAGQ LQTSKQAQAK QQQQQQQQQQ QATQKTNQKA LVLTASGVAE
KCHFCKQRVY LMEKISAEGL TLHRSCLKCH HCHTILRLGS YAFDRDHPEG RFYCTQHFKL
PAKTLKPASR KSQSKSRISG PVIGRVYDAN DASVRVGTIG TIPAPEQGSS TVDYLARNRT
PDNDDSDGEP NMEVIDENEW TDRNFGTESE LSEAEMSSSD ESDSDSESDY EETAGSPLGA
QTLQLASEWI SDKRFSNMVD SDADFYSYSS EDDDADSQTE GEELARAREM RRQEVKLMPP
PTLPTDTETE VATVQKVSES KISETPKVVA APSVTQKALE ESAEDRAIKE RMLKKLSVRE
QWLHAQSSSP DRSESKLAAT EAATTGGSDA GKVKSTSFFG GLMNSLSTLI KPKSQNSPPA
STPSPPPQKV SQQVSHLLVS PSSSLSLPVS TQQTTSECTV KAGSTPPKTI SNTGTGHYQA
AIPPSPKPSL KSEKLVPPSP GASLKNPKTI PPSPTPSLNK HRKHPKSDAS PSRNSEREFE
RLVQDSTSQL SSSPHSQRSG SVLSTSSRSS RHRATPTKDT RDDADEFLRQ IKQEQLEAEK
RSKKQEAKKF KSNMQSIRSA VDGGPKVVGV KSEQDVAKFF AENQKAQATK KPKQLPNKDV
SALQANNLAR YFPGSSGSKT SATGTPSSVS SVEGSPALGR KKASEVDLLK YFGPTGSGKS
TPPSSVVSPV ISRKSSIESP GPIRKTSTSA TLVPKPPVVP LPPKKNILAF QPIRKSKTEV
TIQAAEPKKN VLAFQPKALQ PKSKSPPKPP RSPKMETKKI LSTSPKKASC IDPDEQLFED
LLQDVNDELV DTFDAIVEES RSNKSSPKEM RKNKSSTTTM RKASPKKSKK QSGGSTTTEV
KPTTVTGQAV PKMTIKRPPF KITMPVKMQE TLEEIYLASL SKLDTRSSSL IDLTNLNTPT
ETVEASGSGN VPIASTQLGK VLEEPEGDTR QKSSSPTAAS SFSAPSRNGD SVELTLQPFQ
APQQQQQQQQ QQQQQQTKQQ TSKAAPPNRQ AKDPKATSIP SARTTKKENN NKTAMPTARP
TATTIQEVKP MNGPVEITAV NLKAGSRESL AANQVTPPSG GTPTVSRKII SSVQISLKQS
AQTVPSEPNT KQRDSTLTTV TSNVVGTKLP VSVQTKQVQN DLKHETAQKN VALSSNVKKS
AQTPSSPVAK SAFAPVSKDP LSQKSISMLE LHRTPTVKKQ EDKLDASTIH CNGFATPIAK
RKQQPVGENN LNKLVTTQLP EQDSSPDVKH QKTEQKNVTK QTKSQTQRTS THEEIQQPSK
CVEDVADKKS TDGADVLPKP VPTPHARSRT LSSDEQCFEE LRKKHEALFA NQEKATTQEA
TRTTAHSDIA SVTTPKTLSD VRNSLMTAQP ITTVTTTLET EERIDPHYRE GINQLVMELM
PGIALDTDVP IPKQRQKSSF HKELQKLQRA NVANAVCGPS TEPIKPKTTD NAEYKMEVIR
TASAVKPAAG EKRQGSEEKM QIRLERSTQI KEQYAKASNV LPSTVSSGSA KKQTFVMPNV
PSDIDSHRGI LSRDKMPCKK QEIEDFEDLL EKIEDEVATN EDIDLDELLA DVDDEPKKKT
LSSASYETKN SEKRSDLSAA DKQSKVSMES KTSVGVSSKR VETTASKPTG NINTNSSSGE
NTSNRLSEAK LNETISQLTD KMNQSRKIGN AAPPKTERRT EAEHSKDIFT SLFNTSDASQ
TDLDLFEELC KKEDPEPKQN RSDLVDSSTI ARPSLSPIAA IMPDVISSTK KPSIGEPNAM
KILECMDTLK QGTGASKKSD NIIPSIAPLV VPPQAIQVYT LHTATSTSQD EEKDTQPQPS
TQGMSGDYVH ILKDITSGLV GADFAAPVVY EPPVRDEPKP RKERPDFQAY KQLLEEKASR
EEPIPTSSSS VTAVVEPQPQ RPLRRQKKFD RTDTNSPVRG FDNSICIDPW RARKSASIEN
IAIEQVFVKQ NDAVVDTFFV VPDARQQSVQ RSSKLRRSKS YDRLAVPMGG QRRGSMKQKQ
SLEELRDFGY DVEPSSRSRH LVDPRLRHID LDLGSDEELA SLRDHPARRW QNSSSKFRKN
KSMTDMATGR SVRGKDARAV EPPKVDIDRE SPRPRTTDFS KWEAILDRGV TYYEGGAKAK
PDIKSLEKRI EDLDVRRARP LRRKAIPKDY DPDEYVPRIN RRGADLYDYP DPTLPRDYDP
EEYVPKPSRA HAVPSPPDQP LPRSYDPDEY IPKANRREPP CYEVPVAIQR TPAKYYKDAY
YPADEMPMHY AGPSVPIGRS KTATHVPTTS VAAPITTAAG RAGYEREPPA RDIARSQYSR
RYDAEDRHIV DRSHRLHEKT NKFIRTQLTR NDPNPYIREM MENDSDDDYP YPSNSGAAGY
HQRPALSTSS SMAYGTGSTY GSSGAAAMSR IQTKAITQPS RMLQYSGRKE YPTTSSTIGS
GGSRSIAHSY DHRRRGAPKS SRPELRILRP CETNDVLNSQ PLFRIVLLLP SGASDSEVNS
TEISTDSEFD DEQPQRVPPS FHLEFKPLVE VDPTIKLVQN RAPLAVPRPG DYVLSKTAST
EGIASKKSLE LKKKYLLGEG TTGLGILKSG SASALDSKFK SFHSNITECQ KLLNPAAQIS
PTMQTFLKNS TANQPAAGKT REESTVPVPS LPAESVNDTE KENLYEGKRT GPLGNVNSSS
SALAGANKRS SLIETINTTL VENKLNEIKS NESFIPSGKE EQKSEQPVVT EQQSQSQNAS
PVTKAKHQQS ENDGVGIGHL DSSTKLRNNI NNNNNNNSNN HNNNNNNINN NEDEVIEIID
LVTPEKVKES SPTHRDMVAH ETTGALEHKY ITNMKHAYID LTTDSPNCDR SLVETTLDFS
IAPSKMGNEQ PTNSSAVPDI ISNIRIDSNE NKIEQHATNG VLKQKLASKV TPPEQPNAGQ
AQQQGEDGCH ETTLQVPNID SLMIIDGRYI GDPEDLKLME KLPPDTQIAA QMLQAEINQD
SIGTVIEGDA PHAESDDEGQ RILQGEHVKD DAGETKSDTE EGECASTPTP GPTKTDSADE
QLVASLSNFV SQRNPCFKFD SRNENKIDTL KNLPFVLDAD QRSSLQKSMH LNLTQHKPAD
GETDTEQTPM AGELPVTKLI SSPTAPKPTQ DADSDSQDDT EVTTQNNLTE TELSDWAADD
AVSENFVDLE FALNSNKGTI RRNPKPKHLR LQQKKHPNTN GDGVTLRTGT DRYASVMPPR
NGITATEDGI IRNLALEDIE FMDTGSEEES CIETFSTTNR MMLKNRGYME IMDPSVESKR
TVYPPPLAPL NHGYGSVQPK LVEAINNQVA GRQMDYIEQG SYLLANDDAK TPMNEEPAGK
ITFSALAAAA NQTLKLAEQT NSSVESAHDI EEDSLLLVSS SQGTATATTT NSTTTNDPSD
VLTMVAPLSS MTGQNAEVIP NAPPNSGAGG SSGRGSATSF SSSLQHAGMN SNGHNEPEHG
TKSNSRSRDN SPIRKISVES LSGKRSSLER KDVRKDSLKS IEDIGYEKYV KRLQQRIQQI
SNARDSLEVK KNKRKSSKGE VVLTLAEAGK ELEEPEQEFV RSSSKPGDGS PGQNEYPAVS
FTPDRHQMSV SSIVPEPPKS VEKKIEEITK ERVKQKDLIH DLVMDKLQTK KQLNAEKRLN
RSRNRSNVLV GQIASSSNGN GTGATVDSVV DSPTSIVGDV RDLTENVSFR AGCVGSLKEM
ERTPLAVSNQ PNVYSGAVSI RALPSSMLSG IKSSTSSACD ALKENIAYGN GKPQEHHSSL
LTSSSYQQQL ITPRAVTNPG DPEQSLTTEQ LREEARSRAR LKSNQDLGLS PEDRLLLLRK
KYHITMRGLT DDDDPDAEPN KSDDAKRKDQ QQRTKLITSK SVNDVSMLKP QPHSMAPHRH
QLHHHHHQPG LLVTSTVTKA DPSTPVGDLQ HSPPKQLGDY ISDPNLVHSA TIEQEPGTEV
RLRTRGKRKD RERRKSIIEK VSEFFNGRKK ADGSKEPSPT KDRPSLLSAN GGPSDPATPG
TSSTGGGGFL RFKISPKLKD KSKTKVSSLI INLSHHLFAE CRKQTKESSP YGRCASDDCL
NSNGSNGLPV MANSPVTPAA ADINAGVNHH NSYTPIGRKE AEELEPPPIP PLPLNYERSD
DEAGAANESK NELKKIRAMS KTSRQAELKR LRIAQEIQRE QEEIDVKIKD LETRGVEIEK
ELRGESETLK KTATNSGAND EGLVKEWLEI MSSITRLKVR DDELSIRQQE LQLEHRHAQL
KEELNMRLSF GKLDKNSSDV AAEGAILNEM LEIVAKRQAL RPSPDTKATA AAVAAVAAGG
SLTKTNATFT TRMPKDTDLF KLVRIMFVFS GKLI
//
