ID A0A182MVZ4_9DIPT Unreviewed; 1312 AA.
AC A0A182MVZ4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Roundabout {ECO:0008006|Google:ProtNLM};
OS Anopheles culicifacies.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; culicifacies species complex.
OX NCBI_TaxID=139723 {ECO:0000313|EnsemblMetazoa:ACUA027598-PA, ECO:0000313|Proteomes:UP000075883};
RN [1] {ECO:0000313|Proteomes:UP000075883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A-37 {ECO:0000313|Proteomes:UP000075883};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles culicifacies species A.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACUA027598-PA}
RP IDENTIFICATION.
RC STRAIN=A-37 {ECO:0000313|EnsemblMetazoa:ACUA027598-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCM01000305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 139723.A0A182MVZ4; -.
DR EnsemblMetazoa; ACUA027598-RA; ACUA027598-PA; ACUA027598.
DR VEuPathDB; VectorBase:ACUA027598; -.
DR OrthoDB; 5396194at2759; -.
DR Proteomes; UP000075883; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF49; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 860..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..112
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 116..202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 212..298
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 303..398
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 408..488
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 517..612
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 633..730
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 735..834
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 994..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1312 AA; 141715 MW; 0CDA351687B34A80 CRC64;
MSLRYTAQDE TGRSLEYPKI TEHPLDVIVP RHDPATLNCK AEGIPTPTIT WFKDGEPIKA
DPGSHKMLLP AGGLFFLKVV HSRRETDAGV YWCEATNELG VARSHNATLQ VSVLREEFRL
EPQNTRVAQG ETVLLECGPP RGSPEPTVFW RKNGQTLDLS NSKRIRIVDG GNLAIQDARQ
SDDGRYQCVA KNIVGVREST VAFLRVHGKL KPFLIRGPQD QTVVAGSSVV FQCRVGGEPL
PDVLWRRSAS GGNMPLERVR VLEDRSLRID DITIEDMGEY SCEADNAVGS ITASGTLVVH
SPPSFLVRPK NLLIEPGSEA LFECQATGHP YPTLFWSVEG NRTLLLPGSR MDNLEVTQNA
DGTSVLSITQ IGRMDNGKVI VCSAVNSVGS VSTRVVLSVN LQDDRPPPLI LQGPSNQTLP
IKSVAILPCK ASGFPPPVIS WYKDGIPVLA SEKINITDSG TLAIAELSKI DDSGLYTCVA
SSKSGKTTWS ALLRIDVPTN PNIKFYRAPE ASTFPGPPGK PQVTNINESS VTISWARSSK
VGASSLLGYT VELFGRNQTE GWFQVANRLE DNSFTQTKLS AGVTYYFVVR AENSHGISLP
SPLSEPILLG MSDSFGAGID MSEARASLLS GDVVELVNAT AIDSTSMKLV WEIINGKYVE
GFYIYSRNIN TDRATVGQSY KMMTVLNAGA SSCSVTGLEK YTEYEFFIVP FYKTVEGKPS
NYRLARTLED VPSEPPYGME ALLLNSSAVY LKWKAPPAIS QHGILRTYNI IVRGVDLRTN
YSKVLSNVTI EATSSTLLLA NLTEGVTYTV SIAASTSAGM GPFSNPATLR LDPITKQLDQ
TSHRYPINHN NMDDILTQPW FIAILGCILV LMMLSFGAMV FVKRKHMMMK QSALTALRAH
PAGGVVKIPR NDSLWMNPSG MMWGYQSAGR NKDHIQDYAP VGTTSTLPLE QQHQQNILHD
NRNRYVEYTD YPSDYAEVSS FNPLPHEGTN HLTAQMGGSR APSEYGTGGT RSPAPYATTT
LIGNSRFITA PGGATGNDSH LHHLLPSSAG GKMYFDGDAY SGSSITRAPS DNDSAGYGRN
ACSDSYFNPK EKINITENKL ASHTMSLLAA SNASVSGGYH HLVPSQNGSS NGHSSGANSA
CSASSGSSSS SNGADGGIAV GRSAGSIQPL PTTSQTQTAR TLRNGSNKTR FKLSRTPIVS
SLRSMSKHED TRSSEHGNQE HQKKMSSLNN LGQKQQFYIK VGETGMPGST NSWNHSTASA
MAMSNLYQNA HATMPPGSGG GHGGDPNVVV YLPTGNRSVI SYRASSDRGD DV
//
