ID A0A182MYV6_9DIPT Unreviewed; 1337 AA.
AC A0A182MYV6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR000561-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR000561-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR000561-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR STRING; 7168.A0A182MYV6; -.
DR EnsemblMetazoa; ADIR000561-RA; ADIR000561-PA; ADIR000561.
DR VEuPathDB; VectorBase:ADIR000561; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 23.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1337
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008129037"
FT TRANSMEM 1032..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1086..1221
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1254..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1337 AA; 151931 MW; 76157372A78A0F42 CRC64;
MRSSPALLTM MFGTIFGVFG ASLSKSLVNQ APDECRWDGY SEDDLTLLCR LRTINSELEN
TNFSVLHPEN TVRLRLQCND GLFFQSSLSP GSFKQLTKLH SLSIEYCKIA NLSEGSFQGL
RQLSNLTLRT HNTDWSSISL DIAPQVFNSE LSQLQRLDLS QNNMWSVPDG LICSLTRLSY
LNLTQNRLRD LSVFHFSASL STRLSKKCGS AIITLDLSHN TIDNLPPAIF SGLGKLTDLR
LQSNGLNYIA DRAFEGLVSL SRLEISLNRL TNLPPELFAE AKHIKEIYLQ NNSLNVLAPG
IFSDLKQLLV LDLSNNELTS EWINPATFRG LAKLILLDLS NNKISKLEPT IFRDLVSLQV
LRMQENFIES VAENTFLGLS ALHTVILSSN RLSTIDHITF SGLKSLTLLS LDYNRIARID
RMALRNHSSL QELHLNGNKL LQVPDALYDV PLLRTLDLGE NHISNIDNAS FRHMTHLYGL
RLTENNIEVI RRGTFETMKS LHILNLSQNR LKTVEQSSFD NNTKLQAIRL DGNYLTDIAG
LFTKLPNLLW LNISDNHLEV FDYALIPTGL QWLDIHANKI TELGNYFEIE SQLSLSTIDA
SSNQLTEITG SAIPNSVELL YLNDNLISKV QSYTFFKKPN LTRVDLFGNK ITTLDPNALR
ISAVPDDRAL PEFYIGGNPY QCDCNLNWLQ KSNADSRTQP RLMDLDSIYC KLLYNRGRTY
VPLVEALPNQ FLCKYDTHCF ALCHCCDFYA CDCKMECPKG CTCYHDQSWS SNVVDCSRAG
YDDRLPDQIP MDATQIYLDG NNFRSLGSHA FLGRKRLKIL FLNGSNVETV SNRTFFGLRE
LEILQLDHNL LTALNGFEFE GLDNLKELLL QYNRITRIAN HTFDHLHSLK IVRLDHNRLV
EFNIWHLPKQ LGEIRLAFNP WSCECDFVNR FQEYLKTYDF VRDRLKIRCA AASNATTAVS
AHANHTSHLA DTNQVAVGED LATDGGTSSG GFLVFHDNSS ALCSGAIPLE NVINGNLTSR
KTILSPQPIE GYIPLLVTGL FGFSLVIILT LVLFVFRQEM RVWFHSKFGV RLFYRNADID
KNERDKLFDA FISYSSKDET FVAEELAPML ENDDPSYKLC LHYRDFPVGA YIADNILQAV
ESSRRTIMVL SENFIKSEWC RFEFKSAHHQ VLRDRRRRLI VILLGEVPQK DLDPDIRLYL
KTNTYLQWGD KLFWEKLRFA LPDVPNNQRR QHQPNISLTH SNVRNSYQLT RVAPANRTNN
QLTVQQQDPR APQARSAEYH ASAAQQAQPP LPLPNLTAEM QSQQLQQSSQ QQQQQQQAQF
RAPAPLNTSP RTVGIHI
//
