ID A0A182N081_9DIPT Unreviewed; 895 AA.
AC A0A182N081;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR001036-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR001036-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR001036-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A182N081; -.
DR EnsemblMetazoa; ADIR001036-RA; ADIR001036-PA; ADIR001036.
DR VEuPathDB; VectorBase:ADIR001036; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF83; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 249..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 445..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 491..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 544..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 619..641
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 671..693
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 771..795
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 18..235
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 238..809
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 827..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 104036 MW; 03A53DA553E3CFBC CRC64;
MCKTCRRVHG NCGGTWKYFQ DQKRIVDYVL AFNGEDGSEE AQAKRAKYQQ NLEAEGLQIE
TENCQRIHFV KIHVPEHVLA HYCEIMKMQM PMKKLDNQDK IIMRDFSIQS TLVRLFRRPL
FNFVIIDRQK FAPPEYRLMY EYSRDKPYLF NAREPNFFTP SIRIAVAHFI LERAYFSDAV
DEKKDIGIRR LMEDQVYLDA YPLHDGCTDV KSSCQRALLL EEWASISKWI KHQPLDHIKE
YFGVKIAMYF AWLGFYTHML IPASVVGLIC FLYGLLTYPG NRISQEICSD NSTIMCPQCD
RYCDYWNLNT TCTISKLAHI FDNEMTIVFS IFMSVWATLY LEMWKRYSSR IQHRWGITEY
CSLAEPPRPQ YLSRLKNIKK MMFNVATGAQ EPSPPFWTKK FPSFLYSYSI SLTIATVFGI
VVYRMSLMTS KNIYGDGGPF SGKLIIFPAT TASINLLVST ILTYVYQYVA EYMTNVEYRR
TQTEYNESLN LKIYLFEFVN YYSSIFYIAF VKGKFPGYPA KYNRLLRLRQ EECSPGGCLM
ELCIQLAIIM VGKQAIGAIT EILIPFLVQK FKEFRSVLGI DAENSENGER LVCCNQWTKD
FNLINWHDRS LFNEYLKMVI QYGFITIFVV AFPLAPFFAL LNNVFETRLD AKKFLLYYKR
AVPQRVRDLG IWYNIMHVVG KVAVISSAFI IAFSSNFIPR LMYIRYVSTT GTDEGFVNHS
LAYFNISHFE PNVAPEKTNF TGTICRYTEY RNPPGGSEQY KRPLLYWHIM AIRLTFVVIY
QNLVSLVQIV VAWAIPDVPT RLQDQIKREQ YLTNEYIIEQ EKLKMQRNST GAGGGQQGGP
GTYTHNGYLP SEDSSPDDER LNYGSVADDS EYALRMRTDD FDPAYEGCSI VTSRV
//
