ID A0A182N0G5_9DIPT Unreviewed; 1645 AA.
AC A0A182N0G5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Arf6 guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR001120-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR001120-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR001120-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 7168.A0A182N0G5; -.
DR EnsemblMetazoa; ADIR001120-RA; ADIR001120-PA; ADIR001120.
DR VEuPathDB; VectorBase:ADIR001120; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF376; PH AND SEC7 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
FT DOMAIN 6..88
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 128..210
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1087..1253
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 1332..1445
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 233..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1645 AA; 175849 MW; F55DFFD19BDD4F9F CRC64;
MAEEVTAVLR MSKDGTTFGF LLRQIDIGEH VIYKIIENTP ADMCAKVEIG DIVLKINGAD
VTGLATKDVV KCVRVSSNPM TLQLRKDPEV KGRVYEMIKS TSPERLLHHQ QHQHHHQSPQ
SLVPEEFTVV LRRKTEDTRL GFVVRATDLL DHVIVAIRED SPAALCGKVE IGDVFLKIND
TDAQQYSPRD VLKCLGLATE PIMLRMKRDP WIKNYLREKY QHEEQQLVLS DDSVESAQAG
KQRSDNNKNG SPPTHSPQAG GTPASRLAQP KRSKLLSLDS EPNLNASQGA TPPAVGGRQQ
QAVGNGGSPY AVRECLSESA CRPSRIPQAI VHSNWSAPQS PLRGRKPSRA SQIPTARPDL
LKHQRFVMTG ESQFESRHEA PVVKEMPAEG VRASPGGAQR YGGKRKNAPL VNYDTLSSST
SRSEDNSNSS YYPMEDNANN DPTQPPSPAS PLSPLDGGTG SDNNALVAGG KPHGSNGNNN
LPAGDTFGER LFSESSASNG EAGKADEADG AGSGVHRKSL RQRTQPANHG DAAGGGSRDG
GGRGWSKDCD SPVGGGTRGG VHYENSETTT TTSRQHQQRQ HLRSKHEPIE ASYSVPTSPT
GGGGVGGPDT GSMAGHDQQQ LQQHRNNNEM SINSLPTSPE FGAAGAHHHP MFRYGVSGGV
GGGAGGTLVD HSSNGGGGGG GGGGGDTSSG ELTGTNLSSE SGAAGGGIIR KCDAAGFRTS
RSEDHLQQTQ RDGGIGAVVS IDIDEDVNSS LNTLLDTRHD SQEYAMSERE RFLWSYNAQA
APKTAGTGGD SAIGAVEPGA NVVSPQSYSS SVSSSPQRSA SDSPASPTSV SSSVMSSSGG
SREHSHNGHG GPGAAGSTVG NSISGGTAAS SASNHFHQYQ QQHQHQHQQH HALQQQQQQQ
QHQHQQVQQQ YSGGAGGQHP GQGGYGGGRD HSVSEAVSNI SSPDYQDEHD LLSTKDLMAM
AISDPSDSDS TILISENTHR CDLPLSHSER DHKLVIQVKA GEHGPLDPDD DYDGARCLAL
LKEAERSELA AYDAMDEGML PGAHNLLPNP GHGDPVAAAA AAAAAAAYGG SVTRESSPPV
SDDGSDVDSL HSFHYSPKAV DLPSAERLAK RLYYLEGFKK SDVSRHLCKN NDFSRAVAEE
YLKFFFFECL TLDKALRLFL KQFSLTGETQ ERERVLVHFS KRYLDCNPRS FNSQDAVHTL
TCAIMLLNTD LHGQNIGSKM TCAEFIDNLS DLNDGENFPK NVLKQLYYSI KEKQLEWALD
DDVDLKSGNR NNDGNGNGGN GLGGGNGNGG GGAGPGEGGG GGGGGGATGG SLQGPPVGPN
PFLEAPPMFA AVEYKKGYVM RKCCYDTNYK KTPFGRRSWK MFFCTLRDLV LYLHKDEHGF
RKNQMSDNVH NAIRIHHALA TRASDYTKKQ HVFRLQTADQ SEFLFQTSDS KELQSWIDTI
NFVCASFSAP PLEGGVGSQK RFQRPLLPCT HSRLLMRDQL ASHERQISKI VALLEEHKVS
TAPPKGLALQ NYKEKEVYLQ YELKRYKTYY NLLSSRLTME PQDFNNQHQV STAALNDTGE
RRDDPCSILL PLGGGYDYSA GNSHPVAGVG GAGGGGGGGL LPNFIQQHQD GAPGGGNGTG
RPGFSPPDTA LGQLPRVATE STNSL
//