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Database: UniProt
Entry: A0A182N3N5_9DIPT
LinkDB: A0A182N3N5_9DIPT
Original site: A0A182N3N5_9DIPT 
ID   A0A182N3N5_9DIPT        Unreviewed;      1520 AA.
AC   A0A182N3N5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Calpain {ECO:0008006|Google:ProtNLM};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR002247-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR002247-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR002247-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   STRING; 7168.A0A182N3N5; -.
DR   EnsemblMetazoa; ADIR002247-RA; ADIR002247-PA; ADIR002247.
DR   VEuPathDB; VectorBase:ADIR002247; -.
DR   OrthoDB; 142935at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00214; Calpain_III; 2.
DR   CDD; cd00044; CysPc; 2.
DR   Gene3D; 2.60.120.380; -; 2.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR033883; C2_III.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR10183; CALPAIN; 1.
DR   PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR   Pfam; PF01067; Calpain_III; 2.
DR   Pfam; PF13405; EF-hand_6; 2.
DR   Pfam; PF00648; Peptidase_C2; 2.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00720; calpain_III; 2.
DR   SMART; SM00230; CysPc; 2.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR   SUPFAM; SSF54001; Cysteine proteinases; 2.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   PROSITE; PS50203; CALPAIN_CAT; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00239};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}.
FT   DOMAIN          116..417
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   DOMAIN          738..769
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          838..1139
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   DOMAIN          1442..1473
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        330
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        357
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        891
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        1052
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        1079
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   1520 AA;  173950 MW;  FAB87A80A8F4922A CRC64;
     MVERSNRSSL SKVIRSGLIV PERRKCGYRT PCETTTFVSA WCTGENQYCG VSYILVTLRD
     KTLYDTVVRM SQHAVLRFIL WVVSARIDSA EPTYSPSSNH QSFYALKQQC LARRRLFEDP
     DFPPTDASIA MPRLSGVRWR RATEISSAAQ FFVDGASRMD ICQGALNDCW LLTAATNLTS
     HPWLFKRVLP VDNSFTAGQY AGIFHFRFWE FGQWVEVVID DRLPTDANGT LLFGRSANGD
     EFWSALLEKA YAKFYGSYGA LDGGTAREAM QDLTGGLTEF YQPKKMAGRE EQLWDILRGG
     SEMGSLFACN LKSDPTAENV ATKDGLLRGH SYSITKVHTI PGLLSDSDNT RLLRIRNPWG
     NGVEWNGRWS DKSREWKSLD TAERKRVGLT LENDGEFWIE LADFMKHFDR LEVCHLSPEL
     HSVEETTGEK ESPRGYRWEL SALDGQWIRD TTAGGNVSFL DTFSQNPQYT IHVQEGQTGS
     GAVIALMQKY RRADALPSLT IGFIVYKVTR EDLRQKPVPR EFFQRNDHAI VGGSIFINAR
     EISCRLTLDA GLYLVIPSTF EPGEEGEYLL RIFTARGNTL CENDAILCFG TLDDRITERG
     QFFDTPRWAL LANAFYNRAD SSQQLDQTGL QDVLWQQFFR RSDVSSDSGR FAGQAHKRSG
     TSPLRKFYSC VLQLCACFWM RSSRNKTRRV EEHTVESQNH RQKEELERIV SLLMSRIADG
     QETIGYEQFR TVARDVYQWE TVFRLYDTDG SGTLDRRELR QALRSSGFNI NNRILCRLLR
     MVVELNRPQI ELIDYVLCAA ECRHAIVYHI EHKPTYSPSS NHQTFYTLQQ QCLGRSQLFE
     DPDFPPTDAS IAMPRLSGVR WRRATEISPA AQFFVDGASR MDICQGALND CWLLTAATNL
     TSRPWLFKRV LPVDNSFTAG QYAGIFHFRF WQFGQWVEVV IDDRLPTDAN GELLFGRSSE
     KNEFWSALLE KAYAKFYGSY GALNNGTARE AMQDLTGGLT EFYEPKMMAG KEEQLWDILH
     GGWEMGSLFA CNLKSDPTGR NVTTKDGLLR GHSYSITKIH TISGLLSDSD NTRLLRIRNP
     WGNGVEWNGC WSDRSHKWKS LDAAERKRIG LTIENDGEFW IELADFMKHF DRLEVCHLSP
     ELHSIGETPG TAQPPKPYRW ELSALDGQWI RDTTAGGNVL QNRETFHQNP QYTIHVQDGQ
     PGSGVVIALM QKHRRADGLQ SLAIGFIVYK VTREDLRQKP VPREFFQRQD HAFVHSSIFI
     NAREISCRLT LDAGLYLVIP STFEPGEEGE YLLRIFTARG NTLCENDAIL SFGTLDNRIT
     ERRHFLETVQ FLKLKSAFYN HVDSSHQLDP TGLQEILWQN IFRRRTINSS MSKFHSIVLQ
     LFARFNMRYS STRRNGDQTG DSPNHQCQEL ERIVSLLMSR IADGQDTIGY EQFRTVARDV
     CQWETVFRLY DTDGSGTLDR RELRQALRSS GFHINNRILC RLLRMVEELN RPQIELIDYV
     LCVAECRHAI DEEVKNQGKY
//
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