ID   A0A182N3S9_9DIPT        Unreviewed;       946 AA.
AC   A0A182N3S9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR002291-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR002291-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR002291-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182N3S9; -.
DR   STRING; 7168.A0A182N3S9; -.
DR   EnsemblMetazoa; ADIR002291-RA; ADIR002291-PA; ADIR002291.
DR   VEuPathDB; VectorBase:ADIR002291; -.
DR   OrthoDB; 890110at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 3.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732:SF524; ALDO-KETO REDUCTASE 1B, ISOFORM C-RELATED; 1.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 3.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 3.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 3.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 3.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
FT   DOMAIN          20..294
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          333..603
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          660..922
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
SQ   SEQUENCE   946 AA;  105888 MW;  27C3BCF1F3CFC01D CRC64;
     MACTVVPNAI FRNGNSIPMI GLGTWNSPPG QVAQAVKDAI DVGYRHIDCA HVYQNEHEVG
     EGIAAKIAEG VVKREDLFVT SKLWNTFHRP DLVEGACRTT LKNLKLDYLD LYLIHWPVGY
     KEGPELFPMG PDGQTFQFSD ADYVDTWPEM EKLADAGLVR NIGLSNFNVK QIQRVLDVAR
     IAPATNQIEC HPYLHQSKIT SFCAGQGLIT TAYSPLGSPA RPWVKADDPV LLDDETVGKL
     AQKYGKTAAQ ILIRYQIQLG HVVIPKSVTK ERIVSNFDVF SFQLDDGDVK LLAGLERNGR
     ICPESSAFGH PHHPMSVKAT LVTLNDGKKM PVLGLGTYNL RGQSCVDAVK TAIEAGYRHI
     DTASLYGNEV EVGQAIREKI DDGTVKREDM FVTTKLWNTS HETSQVREAF DASLANLNLG
     YVDLYLMHSP VAAAVNTNGE TILTQFDYVT TWKAMEKLLD TGRVRSLGVS NFNSEQLRRV
     IENGTVKPVT NQVECHVRLN QKKLIRFCKD REIVVTAYSP LVRPGATLGL DDPKSPKPAF
     EDDRVVAVAQ RYHKTPAQVM LRYLVDIGAV PIPKSGNPDR IRENLNIFDF ELTPEEVLSL
     DSLHTGQRLV KFDSAAAHPF YPFDADAAMS KQVPSVRLSN GYDIPVVGYG TYLALEGRGV
     ELVKKAIDIG YRHIDTAYLY ENEKEIGQAI REKIAEGVVR REDLFVTSKL WHSLHDPQHV
     EEAFRRSFDM LDIGYIDLYL MHAPMGLKFA GFEYADMQQK DADGNLLFSD VDYVDTWKAM
     EKLVASGRVR SIGLSNFNSE QIQRILDVAT VKPVNNQVEA NPGYDQRKLI AFCKARGITV
     TAYGPMGRPH RATYGNRSAI DDPKVLEIGQ KYGKTAGQII MRYLIDIGSI PIPYSTNDER
     MRQNLDVCDF KLTDAEIEYM ASFHSSRTSP FLQYKSHKYF PFDIEF
//