ID   A0A182N446_9DIPT        Unreviewed;       709 AA.
AC   A0A182N446;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 2.
DT   22-FEB-2023, entry version 29.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR002410-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR002410-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR002410-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the kindlin family.
CC       {ECO:0000256|ARBA:ARBA00008052}.
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DR   AlphaFoldDB; A0A182N446; -.
DR   STRING; 7168.A0A182N446; -.
DR   EnsemblMetazoa; ADIR002410-RA; ADIR002410-PA; ADIR002410.
DR   VEuPathDB; VectorBase:ADIR002410; -.
DR   OrthoDB; 5399911at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13205; FERM_C_fermitin; 1.
DR   CDD; cd17095; FERM_F0_kindlins; 1.
DR   CDD; cd17096; FERM_F1_kindlins; 1.
DR   CDD; cd01237; PH_fermitin; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR037843; Kindlin/fermitin.
DR   InterPro; IPR040790; Kindlin_2_N.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037837; PH_Kindlin/fermitin.
DR   PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR   PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF18124; Kindlin_2_N; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889}.
FT   DOMAIN          402..509
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          207..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   709 AA;  80843 MW;  29AC7350F0C51EE6 CRC64;
     MIHVGDNTWN LKVYITDLQV QKTLRVRGDL HIGGVMLRLV DPENPKDWSD HALWWPTRNQ
     WLTRTKSTLD QVGLHADALL HFTPMHKTLR VQMPDLRYLD CRVDFSIKTF GAVVALCKDL
     GIRHPEELSL CKPLEPMHLK KNYADLAKKK IPIEQNGNGR DYIHLPPDTN TFIPVAAHNL
     NGSNGSLDGP VNHGPFSCAP VPNSHFSTPK PALQSTPISS PTGTLRHGHG SGFSESSSSI
     GDTTDNLAYS PCAPSPEARS RLLKPKSLIE RARMNIGWLD SSLSIMEQGI REFETLCLRF
     KYYTFFDLNP KYDQVRINQL YEQAKWQLLN EEMDCTEEEM LMFGALQLQV NKQNEVPQAD
     SGIDTSSLDN AADDDVDAAL RELQITLEGP SNGVNAGDIT HIPELTDYLR FLKPKKFTLK
     GYKRYWFTYK DLHLHLYKSR EDSRSNSPPQ VSINLRGCEV TPEVNLAQKK FNIKLEVPME
     QIINSEMWIR CDNEEQYAKW MAACRLASKG RSLADSSYDS EVASIRSFLS MQKPAQAPAI
     NININEMDPN EYLAPRYVKK LKNKAMLRML EAHANVKDLP LIEAKLSYIR AWQSLPEFGV
     TLFVIKFDGH KKEELLGVAS NRIMKMDIAT GDHLKTWRYN TMKAWNVNWE IRCMMVQFQN
     ETVVFSCLSA DCKVIHEFIG GYIFMSMRSK ETNQTLNEEL FHKLTGGWN
//