ID   A0A182N4P4_9DIPT        Unreviewed;       635 AA.
AC   A0A182N4P4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 2.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Choline O-acetyltransferase {ECO:0000256|ARBA:ARBA00040495};
DE            EC=2.3.1.6 {ECO:0000256|ARBA:ARBA00039091};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR002609-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR002609-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR002609-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   AlphaFoldDB; A0A182N4P4; -.
DR   STRING; 7168.A0A182N4P4; -.
DR   EnsemblMetazoa; ADIR002609-RA; ADIR002609-PA; ADIR002609.
DR   VEuPathDB; VectorBase:ADIR002609; -.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF14; CHOLINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          5..624
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        329
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   635 AA;  71734 MW;  36FDA73607B3961F CRC64;
     MLPKVPVPTV EQTMNEYLRV LQPIVTPQQL DRTKSIIKQF SATVGPALQE YLQTKRDTED
     NWAYYYWLND MYMDNPLPLP INSNPGMVMP PRKFTTVNDL AQFAAQLIDQ LMDHKEMLEG
     GGLKQERATS REKGQPLCMA QYYRLLGSCR RPGDPRDSQY LPPSGEQSDA HVIVCCRKHM
     YCVPVKAGDR GRLNENELTA QLLHILNEAP CLPETESAVG ILTTEQRPKW AADREMLLIE
     ERNARNIELI ETALVLICID EPIPLTYNAR GFSGSPAGAH YAGGRDESNM AHEMIHGGGS
     AYNTANRWFD KTMQLIICSD GTWGLCYEHS PSEGIAVVQL LEGILKRIDE APAREESAEQ
     LPLHQQSHLP PPERLEWIVR PEIERRLREA ARSIDSRIED LDFYVYRYKP YGKNFIKACQ
     VSPDVFIQCA LQLAHYKLYG HLVSTYESAS TRRFLLGRVD CIRSASTEAL EWAKAMCQGE
     GPNVTLESDK EDDYSAEAAA DVKKRDHLRE LFRCAAARQT EVMVQNILGY GIDIPLLGLR
     EACREREGHM HELFTDECYK IANCFLLSTS QVACSTNSFM GYGPVTPHGY GASYNPHPNE
     IIFCISAFFT SDKTSASRFA RSLQDSLDAM RDLLS
//