ID A0A182N7Y4_9DIPT Unreviewed; 746 AA.
AC A0A182N7Y4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=Transmembrane protein 200A {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR003758-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR003758-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR003758-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM200 family.
CC {ECO:0000256|ARBA:ARBA00005308}.
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DR AlphaFoldDB; A0A182N7Y4; -.
DR STRING; 7168.A0A182N7Y4; -.
DR EnsemblMetazoa; ADIR003758-RA; ADIR003758-PA; ADIR003758.
DR VEuPathDB; VectorBase:ADIR003758; -.
DR OrthoDB; 3037833at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018787; DUF2371_TMEM200.
DR PANTHER; PTHR31815; AGAP005329-PA; 1.
DR PANTHER; PTHR31815:SF1; AGAP005329-PA; 1.
DR Pfam; PF10177; DUF2371; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 80128 MW; 3DAFD3AE3E02B620 CRC64;
MHARGGSQWQ SRRKTSLGPL RRAHPASGAT WNVQVVRGKM TSRCLWHACR ALVLGMVLMF
VGGGMATVGY YANNFPSLSD VRSNSTSTIR VKNEHRGLHL NNLSYVGPII MGVGGFIVVA
SCVMTFEARD SAAKVVPARF KMNAQGSARN PGRNNNSRRS TGVSNGPTAL IGSQTARWEQ
HLGVFRTSPA TEQVPDRKAL TAALVHFSKA LGTPKSSPHR RPSESQSRRV SRSGSVPNLY
AEKLSVPSLV SGSPANIRSE AGGHRHHRGT RVSSMVQRST RDAVSSGLLH PGMLQFHRHA
LSVDEPEPLA RTLNQAGSHG SVQYGYGGEI VPVHKLRDRN KRSDTARRHV LSRQTKIEKD
ESLGSPKHGH ISRRASTVSN TSVSSKLNRG SRRASTISKT PSVDSRGAAS TIEINSPDRS
LLLGLTPPRK GTQPAFGPIS TPSVEKECRS QLSICSEPAA ISQRNLSCQS SLEPCVPEEE
SSPEYEQTGE EDNDDGAGGK RQPSNATVEP LSVANPPLRP DSLVLGAQEP NLPTADARDD
RTGQHPTRQL PLYRSNSSKS FRKPKVKVAS KKLSNEYDQI YVISGAGAAG GSGATGSNRY
PNFQHQTARH PTDDDHYDSI EVIHERRSKN FSKFSTPEAP SAQGEGVGGE GVGRADDPST
GGTLDGEYRK MGSNVISVVA DISPAPVPNA ELVDASPRES FVRDAAYECP PATDGNNSPG
QPMVVEHAND SSEQEAPAND ERKDAQ
//
