ID A0A182N8C4_9DIPT Unreviewed; 1638 AA.
AC A0A182N8C4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR003898-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR003898-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR003898-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR STRING; 7168.A0A182N8C4; -.
DR EnsemblMetazoa; ADIR003898-RA; ADIR003898-PA; ADIR003898.
DR VEuPathDB; VectorBase:ADIR003898; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18018; DEXHc_RecQ4-like; 1.
DR CDD; cd22289; RecQL4_SLD2_NTD; 1.
DR Gene3D; 1.10.10.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001878; Znf_CCHC.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF108; ATP-DEPENDENT DNA HELICASE Q4; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11719; Drc1-Sld2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 717..732
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 906..1083
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1105..1278
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..813
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1638 AA; 182243 MW; 6DB370A2DF64E9CF CRC64;
MEDHAFRAKY QKCKYRVKQW EKEFKNKNGR VPSKLDIRDS PREIKNSYKM YYQLKTSLLK
DTLLDALDDD DDFDGSLISQ ECSFSQDVSD VSGMLTSGTI LNESALLDRS SSMSSLLTKP
IGGTSTGNSS TVFAAEQVDK HNLTAWQDEK NRKPKPVAEM QKESETPKPV TMKTMQLMPQ
SSLLLPKRNP RKSMSRNSFG PAVQGASGLS DTGGSKIVLP DLETLLTAKS KELENIAPKV
EPPLLLTASE PINQLDERWL KRQSGGTADN STVHVNANHQ STTNFGLRNV NLASIASSAS
FGMSSLSVSE KPDATDVGQS RQEERTGVQN TAYDRAMHSD SDGVIENSED ESAKTSPGMM
HIAKKRKIFT SINRSPVERS ESKLSSPKLV PEMLAQNDRR DVENQDPSKE MVPEPEHEHG
STPMVPKKRS SKKTPKAKTK QETKKLVEKV KTTVVPRSRS TRSNARKVAT YKEPTIGDME
EESAHGFSSD DEDKDPDYKE QIEQCDESIK HESEEEVERT KSPPAKQTRS ARPVAPPKQT
RVRRTTKKFS AISPKLSPGS SKPVVKAKKG KKPTQRKIDV DEEAERLEEP QEYVPEFGLD
RLKSIPRVDI NELARDAKIA DSFILGAAGR PELKGSVGGK KAAAAGAKDT ALRKKMAAGK
LNENFVRIDL RKKVFVKGKK TINYSRYKKA QWKAKKVAAL SGPDMDMRGC DGGVLTCFQC
GGTGHMAFQC KKPIEDKLLP HDPDATEDSA FPTLEEAAAM ASDRTAVVHS SRMENLPAVA
NPTWKMDGDK EEDGAAEEEE EAKEASIDPE DFEDEIEPDA VETRILSPPA PATQTTSTYI
GHKIPEDFLK KSGLLEVTVS GGFKGTIEPL YRAQPGGAFP PTPSEVFEAL RMFGHESFRH
GQERAVMRVL CGMSTLVTLS TGAGKSLCYQ LPAYLYRQKG NCITLVISPL VSLMEDQVHG
MPDFLNAHCL HTNQTPKIRD RTMQAITAGE VDVLLISPEA VVAGEKSTGF GSLLRQLPPI
AFACIDEAHC VSQWSHNFRP SYLMICKVLK EKLGVKTILG LTATATVQTR QSIVSHLAIP
DGLQGIISDI PLPDNLLLTV SRDANRDAAL VELLQSDRFR ALQSIIVYCT RRDDCERVAT
FIRTCFQDAA RARAAEANAN KRKRLNYVAE PYHAGMPASR RRTIQNAFMG GELRIVVATI
AFGMGINKAD IRAIIHYNMP KNFESYVQEV GRAGRDGLLS HCHLFLDNKG NDRNELRRFI
YANSIDRHVI RKLLQKIFVP CACAKILTNK NLAKELRQEL EAVNGIDWDA EFFEAESQPT
ATNGQSRHTG NRKRLCPGHE ICFSIESTVQ QLDIPEENIA TFLCYLELDE QRYIQALSPA
YTLCKVMSYG GVRPLRQAAK ECPPLAMAFA LDLKRGISHA ASTAIEFPVI DVASAIGWDS
GVVKYQLKNL EWTMVNNVRK RSPLSVNFTD LGFRVRAPGD LSDDELDRTL DALYERVTHQ
ERTQLSQLQY ISQALNSVCF NSIGPVCRED CPTGPSDKLK TIVREYFLTD ISKENIEIIP
EPDDTTDEQL IADIRTTIYR YPENNFTGRA IARLFHGVQS PNYPALVWSR SNFWRAYTKT
DFNRIVRLAN AEIVRIRT
//
