ID A0A182N8F9_9DIPT Unreviewed; 673 AA.
AC A0A182N8F9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR003933-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR003933-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR003933-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A182N8F9; -.
DR STRING; 7168.A0A182N8F9; -.
DR EnsemblMetazoa; ADIR003933-RA; ADIR003933-PA; ADIR003933.
DR VEuPathDB; VectorBase:ADIR003933; -.
DR OrthoDB; 2898719at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF6; HEAD-SPECIFIC GUANYLATE CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 2.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
FT DOMAIN 455..582
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 396..423
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 673 AA; 75123 MW; 6FC6A51E3CD12990 CRC64;
MACPFAKHVS GEQFQRQPSI AEAHNWNLDE DLSEIPGDAL TLTHLNAAIQ LLTAPSIDNV
HEALMSLIGK YSNRWPGLSK LKSERSELSI YPHYDYLADI QDNLTQIDES AVSEILVHLG
EELIQTACVG VVERAFKCLG SDLQEFLGSL DGVYDVLKLQ EEDISDTGFV CAGEGELIFT
SERPVLAWML LGCLRALSRT LFGCEPDIEL EPLPGDTPRY RYLLRLDEPV VDVAPGDAVS
GEARDLKVSN RFFCDAFPWH FIMDEQLRLV QMGSAFSRLF KGHVGAGTAG LCAGTVFRFK
RPRGLQLHFR EIVRRTNTPF MISLRAPPGR PDFFAKGLEI KGQMVFCPES NALLFVGSPF
LDGLEGLTCN GLFISDIPLH DATREVILVG EQARAQDGLR RRMDKLKSSI EEANAAVIKE
RKKNVSLLQL IFPAEIAERL WLGAQIDAKT YPEVTMLFSD IVGFTSICSR ATPFMVINML
ENLYKHFDEL CGFFDVYKVE TIGDAYCVAS GLHRAGNYDA HKVAWMALRM IETCTLYNTH
DGQHIKMRIG IHTGTVLAGV VGRKMPRYCL FGHNVTIANK FESGSEACKI NISPTTREWL
VKQPDYGFQL DARDATCMPK EFTDSAGLTC YFLEGYKHPT LGNDRPLQEH IEEAMRQTLL
DTADTTITVE VGQ
//