ID   A0A182N933_9DIPT        Unreviewed;       774 AA.
AC   A0A182N933;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Peptidase S1 domain-containing protein {ECO:0000259|PROSITE:PS50240};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR004157-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR004157-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR004157-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC       {ECO:0000256|ARBA:ARBA00024195}.
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DR   AlphaFoldDB; A0A182N933; -.
DR   STRING; 7168.A0A182N933; -.
DR   EnsemblMetazoa; ADIR004157-RA; ADIR004157-PA; ADIR004157.
DR   VEuPathDB; VectorBase:ADIR004157; -.
DR   OrthoDB; 3410499at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 4.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24260; -; 1.
DR   PANTHER; PTHR24260:SF149; CLIP DOMAIN-CONTAINING SERINE PROTEASE-RELATED; 1.
DR   Pfam; PF00089; Trypsin; 3.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 3.
DR   PROSITE; PS50240; TRYPSIN_DOM; 2.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          46..260
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          293..529
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   774 AA;  87180 MW;  B0BAD8AE822F856E CRC64;
     CDVRFFKEQT ASFAAPVASQ PAYLREFAHI AAIGWTQPNG NVVWGCGGSL VWENFILTAA
     HCSADDNDVP PDVARMGDIN IYSDEDDEFA QELKIVDIVR HPKHRFGRKY YDIALMKLER
     NVSVHETVAP TCLWVDDEIR FPKLLAAGWG AIGIGEKHTE TLMKVEVAPV SNAECSRYHV
     AGELGLKQGL QDDQMCAVDK EMDTCPGDSG GPLHVKLFKD KKMIPFLVGV TSFGKACGLS
     VPSVYVKVSK FVDWIVETLQ QHGELATRFK FEPLVCTDRY YYLREYKEDI GKVINGIEYI
     DLSILYVSLR MSDFIVDFRW KDTSFMRPDC FGTLIEPNIV VTLAQCVMDR RTNPTQVVLN
     SSRAIDIVDI IVHPAYKPST DPYYNNIAVV KLESYAYIEP YCVWYGNHNP GMNVLLTGKR
     LIPEEHTTIP HHITIMTRGN ERTSEQCHLA QRYISALREG LKEEHLCFEN QPFIVPESCE
     LKLGGPIERK YGKVFIDGIN LFGRDCGYGE PAVGVRLSAH KAWLESVLLP QPLNTVLYID
     SDLFAGDKCR YADGTAGLCV PQTQCSNIHE RIRTQKQIIF CKTGSVVCCP QTPTNLQTIE
     REFNECEQRY LHLRTKEYDF KAHVVEIGWK NNVNTATNCL GYLISTRGVV TSASCLRAMS
     VSQKIVKLGG DQFIGIEAVK FHPKYSQTTN WHNVAVVKLV SAVQPSVTAF PGCLWMNVTH
     SPVLQFILNV DSAKYDPIHP MYKSDCEGLL KLSFDESETI CMNPDHPLQQ KKIL
//