ID   A0A182N9A5_9DIPT        Unreviewed;      1096 AA.
AC   A0A182N9A5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR004229-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR004229-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR004229-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A182N9A5; -.
DR   STRING; 7168.A0A182N9A5; -.
DR   EnsemblMetazoa; ADIR004229-RA; ADIR004229-PA; ADIR004229.
DR   VEuPathDB; VectorBase:ADIR004229; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          19..87
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          394..431
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          632..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1096 AA;  122017 MW;  2A106078C9FFB858 CRC64;
     MEQIIKNLLV ADNDLIQQAS TDLKEAFKKP ETIPQLCEIC VTNGDAQVRQ YAAMLLKKHL
     GKLRAWREVP AETQALIKKG MLEAIVNESE KSVRNAITGF VGVLVKHEAE KEDGWMGEVL
     KFMFDSTSSS DPKVSELGSS VFATLTDVAP DQFMPHIEMV CRLFSGALMA SDASGNMATP
     VIYNILLGMS HLVPFIPGRQ EVEQTYQDSI PYVLKALAAF GEKDSFQFIE AFEILENLAD
     ESSRTLSPHM KLLIDFCLQL AGNTQLEDSV RVKTITFVGW LVRLKKKMII KQKLVEPIVN
     ALFALMSVAP DVEDEDEEYF GSNEVSTPST CATQSLDVLA LHIPPKQLFP PLMALLEPAL
     AGTDPLPKKA AYLSIAVIAE GCSEHICSKY LRVLVDVIKR GITDENVMIR NAALFALGQF
     SEHLQPEISQ HADEILPILF EFLQQLCLQI RSGGKEPPHI DRVFYALETT CENLEDQVTP
     YLPMLMERLF ESLDTRNSVH LRELSLTTIA ATASAAKEHM LPYFARLIDS LKVYLVKSDD
     EDICTLRPQA IDTFAALVRT IGKDNFLPLA VDTLNLGLTM LDESNDPDLR RSCYNLFASM
     ASSVKEDMAG SLNKIVEAML ESVRSSEGVV PTFKDGGDGD MPILPNGAAN GGGGAEDDDE
     EFDIENSVGD EDEEEDEEDI AGYSIENAYM DEKEEAILAL MEFAEHTGPA FAPFIQTAFE
     EIYKLLNHPN EDIRKASIDA VKQFVVALHQ LGNTEGVNQT ILILVPKLSE IIRTDEERTV
     VMSALDGFSD ILQEVGSATF QADGQKDAVF NCIVDVLNGK VACQFDEPVD EEQEESEYDE
     AILESAGDIL PKFGRALPAE EFAVYFGRVW PYFIQKIEKT KQKDETTDSQ RAFAIGVLAE
     CFEGLKEYTR NWLDTLLPIF LSCVQDRNNE VRSNTVYGLG EMVRHGNECT YGHYPQIMAA
     LSQLVSKEQH AGTLDNLCGA LARLITTNCS LVPLKSVLPV FVQYLPLRED FTENLAVFRC
     LDLLYRQGDE NLIPLLSRVL VVGLQVLYKK EHDTDETREL VMNLVKQISK DFPDKFSEVI
     RSDAEIAGFV QTLMLQ
//