ID   A0A182NA04_9DIPT        Unreviewed;       951 AA.
AC   A0A182NA04;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR004480-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR004480-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR004480-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A182NA04; -.
DR   STRING; 7168.A0A182NA04; -.
DR   EnsemblMetazoa; ADIR004480-RA; ADIR004480-PA; ADIR004480.
DR   VEuPathDB; VectorBase:ADIR004480; -.
DR   OrthoDB; 3385940at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF130; PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        438..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        467..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        535..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        761..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        800..825
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        846..870
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        882..905
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          332..492
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   951 AA;  107454 MW;  F03C6130FF8ABA17 CRC64;
     QLLELVIVKL SEKLVDIERR GLGYWIANNA WKTIALCWLL VALCSVGFIR FHKEKSPMKL
     WIPLGSKFQH DTNWLIEHFQ EGNRIETVMI TAPDVLVPEV LQMIATITEE VEGFTFHNSE
     GKRLGWTDVC HKVPLIAEYT SDLSRKKRYA LELQEKSVTT RRPKKSKPFF TPVIDVPSFL
     FCPMVERLEM GCYGSNLLEL WKYNRTSIAA LSKEEIVDKL NGTRISPMTG HTVEFAELLG
     DVKRDWSGRI VSATSLVTHW FVHVNFSEVD ADVSGNAAGT EDWVTENAVL WEEKFLKIIA
     KAKSELSNNE TNIYYAAGRS YGDISEESMF KDMDKLIYGG IVMFIYMQLV LSKFSWTEFR
     VILGSVGLMS VGMGFISGCG IVALIGVSYG PVHTSLPFLL MGLGVDDMFV MMACYRKVRK
     ANPDLPLSER MGLMLQHAGA SITVTSLTDI VAFVVGSITV IPSLQSFCIY AAAGVFMMFL
     YVITFFVAIF TLDEIRIANR RNSFLLWVVH DEKSTSLWCE YNLMHRFINM LYSKFLLTTV
     GKTFVILAVV LMTTANVHSL LKLRQKFDPN WFIPEETYYN QFVVKTHEHY PNAGYEALLL
     FGNLNYTAEL PNLIRITHQL ENRSDILHSV GSWVTSFQDF VHMHYDKDIA VNTLSDSDFR
     KYLTKFLFSY EGGRYQMNIK FATKLKCGQP APNITVTTMD FKFKPFKERE EYLPAKYAVE
     DILESSNIST GDHYRTLWAK IFGNWVTDEI IDTEIYRNVS LALIGVMFCS VVLIVNLQIC
     FWIFICVLLT LVNVGGLMQV WGLTLDLVSC IALQLAVGLC VDYAAHIGHT FLTINKGDKN
     RRSLETVLHI GAAVFYGGGS TILSLSILSG SQAYTYRTFF KIFLLVIAFG LFHGTILLPV
     ILSLIGPAPY SGSLNSLNTI NNNPSPTKKA CGTEMISFIG DEKYVRTSGE F
//