ID A0A182NAB4_9DIPT Unreviewed; 2920 AA.
AC A0A182NAB4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=PH domain-containing protein {ECO:0000313|EnsemblMetazoa:ADIR004590-PA};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR004590-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR004590-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR004590-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 7168.A0A182NAB4; -.
DR EnsemblMetazoa; ADIR004590-RA; ADIR004590-PA; ADIR004590.
DR VEuPathDB; VectorBase:ADIR004590; -.
DR OrthoDB; 4609983at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752:SF9; KRAMER, ISOFORM I; 1.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 556..655
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1838..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..1914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1972..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2366..2455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2644..2666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2897..2920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 213..245
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2366..2400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2426..2455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2525..2539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2920 AA; 319064 MW; 3D8ED1C3138F01EA CRC64;
MKSAKIDPPT FTTMESKKLQ QLQQANSHLA PMPQMKPPQG SSFQHPPSVG YDYGATSTAG
RSAMFAPNAS QYQNYGQHSQ HPSSSQRSPY STGSPKSSLS TNSGALYGAT DGGDLSSTSG
GGLSHHMHSG QGQAVLHPHQ QFRSNTLGNG GSYAYDQQQQ QIYRVHSPSS GSGGERDRLY
QTAPLARTTG PASGVGTPHS VTSGLSGAHN APLSKLELQF QQLQREKIQQ QIKTATEAIA
HQQQTFALRQ QLNPPVPNYH LKQNLLQNLS QVHQQQIQQQ QQQQHQHQQQ QQQQQQQQQQ
QQQQQQQQQH QQQQQPQPQH QLQVHKHPNY PAQQPQPKQL AQQQKQQQQQ QQQQQQHQQH
QQRQQKQQQQ QQQKLQQQQQ QQMQHTLKQQ RYNSSGPQNR SVPPSSLNLL NHCQPAASET
DKIIRSHVPS YHVTADTVGS GINGAYGEEE SLYHQKGGLQ HGVVVSPPGG NNEIIIQQNI
PGQVVNQACQ TQISSMVLAG STGVVQHHQP QVKSSPSDTL SSPSHDSSER KRGAGGGTGQ
QHTLKSPVTK RPANAPVALS GWLYKQGSDG LKVWRRRWFV LSEYVLYYYK GQEEEKLLGT
VLLPSYKVSA CFSEDKIYRK FAFKCEHANM RTFVFAAESG ESMSQWVRAL TFATMMIQQG
STEHEGNSNQ LQFSGSMAKC SGSAGEVLSS DSSGTGGPPS QGANDTMKLI QQTSGNGSSS
SSGGCSAGIN DSMSLPQPLY ANAPPKPRRV NDAGYSSPSP EHTILHDRYE QMVQHQQMLS
SAGLFSGAAP PLQGTAGGGL VLGNNRTPSA LSANAIYGDP KRIERDLYIQ KLIEQQQQLN
ASKQQHHHQQ QQQQQATMQS SPKHGQLLRG TPGIGTNPFL YPSNDRRTPD TYGPQNSTID
PKHMSDYEDI YNLTMLSKSL PTSNITGAIE GATGGASYKR PSSPLRYGSN GPFSPYFGNA
VYNVGQFEQS SVPAPAPLQQ HVQMRARPVP PSIPRPHSAD FLDYETRHPV MQDASGANDE
PSPVHRTPRP KSSLDINRTP DHYYYSEANY AEKMRLQSAS YLQRANNSGT GSSRKQRSDE
MQGLFISGTM PREGLYRSGS GKIMPSHQQQ QMDDYPLGSQ SMPRSSATDR PSGGSRPSVH
SLKKQGSGSA QQQEQFARSA SARLPRKEED SSLQDGERKR EESMKRLLEW KQRMLQSPLT
KKIASQHSAT MASAESLNPA GSTVSIAGNR QHEDIYGMKP DSSLLRGDYY SSTYERQSIG
DLTAIGSASA GKHGGSAVNI AQASAYGSEM KLNGDYNSYS SDDEDGRNFT PAGRSSPLVS
TASTKDVAEA PPPPPPPPHY LTQHSHSNQF TEVACSAGTG STENMMHPLT HTFYAGTAGG
EGCGTARIIR TDTDEGCTDR YRGKKQGAEN TAAQLTLVEP ANEEEHEMYE DSLVNNASVT
TSPNLSVDAN VYENSFIKGS RDQKIAGNEM NQGIGERSDR ELKNEQSSEP IERPVNKKAN
ASDKLKSGAG CNIRLNANGN DNTLLIAEMS APNQHERPLQ AYVPVYKQNI SPLSVNSLHS
SASNASNEVF KEQPMELTRK TTDDPTRNVT SSDQNHNLDS VDDKNTDEAD DVLEYTDEDL
DEALQHAEQT ADPERDRTIL TKEDLSAELL RGEEMDDELS MQILEGHYMP MTPRKSLISS
ASSCTTLALL NRNNIMLNQA VQPLSSAALE QLRQSESLTA MDILDSIQKG NKMQICNPYD
ESTYIEMTKG TLGKSVFAAA EELRGTTTYE MIMIPESSRS LTEVVNENGS RSGPDVNRIT
LADSEPLYME LSQLHSSISA MSKHETERVS FDGIAKSDEK IDTNDGQAKK MPNSTESTTG
VEKEPIEKTG TISRVKNVMT VGTNSASKKK KKKDKNWPDI VMQSSKTDYS DSESDATDKA
LVECKRGKKK SGVTDKEMSN VPANLQSQTM PRSRFSLSDT FRPASYYLGA SSGSSTPFGH
ANGRDGGGGN AFDTLLDSSD SEIVSPPPIP ITSLPLDEPD SGCVDERKML LKVVDLPRYA
NREKFRSSEA IDLIKNHTQE KRQSVQSLVT GTSSGQSLAG SMNLSYDMRR ESGSMSSNRS
SLRSSSQALY VTNNTITGVS ASKQDRSYDA STACVTNASS EYELLLRELG TTEGGKLSMV
AMGGRRNNST ARSSITLSET SGSVEWRSRS CMDVSMRNKR RPISGSSLNC PIEQVLDGRG
VEDIESVALD SNQFDRYLNH LSSEGPWVGN QGINDTNFAT DYGGPLNNSS SILSQTGHDN
SIYYENVEKL GSTISESTSR DSSKPILSPL REKNLSLHDA RCQSEYLGTV LEGHSLDMDS
ASFSLAMDPD QRSSCTVRYD YDRSNQCNRT ITPTDGGAQS VTTEPLHSRN NSTLSSEGAP
YYYSDLQARS PDADKDHHGR LSNERRGGSG GNNSTHASSA TGDTLNNQRD PGGLRRQTTS
SIFHIQNPLN TLKTANLLVH ASATEKHADI DRKNIYESDR LGQKDVNKTI AASLAAGGNG
RIAGSPSSLA MNSTPKDGNA TFSRRQIEAF GRSSVQHQAP IELGQYPETN GVVAGACSNS
SSSNIHRVLD ASGDNFSSGD QHWEEDTLWR DNLRRVSHIH AKSMDNLDNL GKISAPSAAL
LAKTINQHQQ QQEQRQHDNS SKAELNKKPI VKINRRDVTY VNDHQSHVPV TNPSVDDQFA
APTKQKKSIL HLLTFSNADI QASSGLSNEV IHTEDHRADS DRCNGDDDDV YVQLASNVSS
TGTTVRDGRW SSSSGRESDA VYEVLRDEIS RYDINRETIR QWDLMSSGLV NSSTMSNTGK
GVGGSKSFVS NSTSGAVNEK AITEIVTTTE NDTRNFFGAT GRLHSTKQSL NETFGKTNDV
SSASSLSSIR YNTTLGKSQM AESVKDIDGG HPQSTNNRND
//
