ID A0A182NBT9_9DIPT Unreviewed; 4575 AA.
AC A0A182NBT9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=UBA domain-containing protein {ECO:0000313|EnsemblMetazoa:ADIR005119-PA};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR005119-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR005119-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR005119-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR STRING; 7168.A0A182NBT9; -.
DR EnsemblMetazoa; ADIR005119-RA; ADIR005119-PA; ADIR005119.
DR VEuPathDB; VectorBase:ADIR005119; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2750..2790
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 426..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1998..2050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2708..2741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2791..2820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3232..3253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3786..3811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4378..4399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2710..2724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2725..2741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3789..3803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4575 AA; 505465 MW; 739B50B2DEFFE9F8 CRC64;
MLRELIAWVL NNYLGKYVEN LNTAQLTIAL LSGQVELENL PLRKDALRHF GLPLQIVSGS
IGKVKLTVPV RAFRTASWCL YIDNVQVTCG PIDLEQDWNA EVEQQTELDL KVASLDRLEA
KWRAQRETPV TEGSYYASSY SGWLNYGTTL VTNIIENLQL TVNGIHVRYE DALTVPRQHF
ACGIKIDSLS AQSCDASWTP GKTANWSTQH LTFKLVELTN FSVYWDPRAE HEPVHMISPI
SVRAQLRRDR SETPLRTRSR PRLVCDLIWE EIKIALSDIQ YNQMMQCVRG LDDIARFRRF
KLQRPSSPVA GAARDWWRYA VRCHGLCRHL GADPYEIAKE NMQYIRIYQR IVANPNEVLT
SANKQYKDRI ERERTFDELR LLRDVCMSQM PKLEKSNNSP AVQPAQTGKS MLVHYFPQWW
YSKNNNSSNG AEGTEQQRTP PGTGEDDVIV PSVGEDGGSN QQLAIMPNSD WDGELSAGSS
SSIEDELLDA LAGSVESNSL LKRDAVFGKF NFILKRGTLD FCSAHELAPK LQFLFQDLKM
DVESRPRSGS HYVGLSLGSI LIKDRLTVNS QFPDLVKPQQ KEEQKGASGT NTSTPLSARS
SSGRLSATSL PAGDPSGSIE PIFQLQYERK PLSYNTDYRL MVKSESLDIV YNMEAVRWLV
DFLAKPHQQY DARRRLEDMK NKTKQELMRN WNYIIEGHLS ERKTWTLEFD ISAPQIIFVD
NFSDRINSTI VVVDFGRLQL TNGENGFNTD ATPAAATVAS TTTRASSTSK TTGGFFTVGG
GQRDISPELT ATENDEDDAF MTPCSTPPGS EASTTNSPTL VSAFSEMPDV VTAAAAIGDA
LDEYQLYQRL YDRYHLQLTD LQVLVCHAKE RWTAASLKST SNLHVLDRFS IVLQVERRVV
YTCDPQYPSL TLSGTLPKLN AHINEYKVSS ILTLVNKLSR WSGSPEPPAE VWDSNLGPTS
SSTKQPPNET TSTASHANDE DASRASSSSL GKESATNIVV FQFTIDQMSL EVQSRGRSVA
ELQVSGVKAG YSQRPEDVSL TLSVHGLLLV DAMQSFGQDF ELLIASHRHV GMDSLSGSLR
QSEPCSPCSP ASPPDPLMEL RRPTSPLTIS KALNNLQRAT SPTWNAATLG DLDALITVEI
VFVTAERPED KLQVANIQFN NLDIIANQET IVELLGFVKR VIPVPAPAPP EQPGGRWHGG
EGQVGGEYVS DGMHPLQTPQ MTPSGGAARR PSLSSSLSDT PPAHPVRLEI TFDFHRLNVL
VLRALLRDNY LVGRKVGTFT MSEAKIHATL GNDITVEGSL GGLQVLDLTP EGVNHQRVLS
VGKDPLTDAT TTAARYEPPD SAGPDLMASL AQEVYGEGGL GSKRTAEHGT EEIGMHEERQ
ALSFCVSKDL HACIDIRVKM ASVWFIHCAR FMQELSWCAT EFKHYLKNLA RSIREKATDM
ALGLVQSRTD LSSSRPESMY ASPRRVRRQR TVSLSRTQDV LLNADYTLKV DITLDTPVLI
LPRSGSSPQV LVAHLGRITV SNTEESDAAD GGGASPSSSS QERIVVNLSS SSPPLEEEFG
GGGYLFSGAD RTSVDCNLSD LDGIYETTDG GNINTASSRI RFAKEDSTEF IDSIADGIDK
RNLDRYKIDF RNINLYSLDT TNRKGFRFAG LPRAEEFYSC RDNAIPIIHD TIFSLEICRE
HGGPTLETED DAADGFRIVG CVVKPLRLSL KRQQYEQLLE TIDNLFTIPK DLIRPPSEVP
TTLEKVTEIA EESLSFHTFP MPSKARQGLF YQSSLDQRAS GAAGVGSSAI SIRVHFELPA
FIIQLNGNRN EALVQISFRD FCVDFDKRKL YETHVKISLR SLLMEDLLQS DTAKNRYMVV
TSAEHDPNER LNTSTFASHS CPNPVGLLLG MGEGLPNSLP TNLEDRMGFS FLAANKSLCP
DTPPPSPSVQ KPGSRLNPEE NLVIYSSVLV DPSCPTFATQ FNSLQQSSLI DFNSLDLIVS
VESWFVLLDF FGLLSDDTDA GSSSDKSQSM TGARGDGARR KEGTSGNNSH NDPAAGLHPQ
QQQSQMSGAA GQSKLEISVR SLSLVLANPT CEIAKANVSN AQLTISKRGQ AKKVEGSLGS
ITLHDLTPYG TLYREKFMTT GTEALNFMYV RDAAKGTVRG LQKDAQLTIA MSSVRYIHTK
RFIAEIQLFF KEFSHLQTPM MRKIKPSDVR AYHNQRPTQL GLSINAGAPI ILLPMSYNSE
QVIVADLGEF TLSNEFRLSA GDREVLDVMH VNLFHTDIFA ARMEAAPEER FVHIPSTTAA
SGAGGIDMKG YRLVKKGSSL LKEKCHLKLE VERNLDSLNS HFVPDISVHG KLSKLDALLD
LQQYRLIRGF LSHNLGESID ELYLRAFSIP NSTLSLNAVD APDAQEEVWK NLSIHLELLD
VSVRLVQTLD DEECYGTAPL ACVNFIKSKL LVDCFSDGAQ DIDLVSQEIQ LIDTRFLPTE
CGSGSSSLAR GARLSRNVAN RSSSAEVLNV FPNILQPIRG EPGTELVQAE IHSRRRKDLT
KFTILLNNMR LMAILDWLES ARDFILQQED PPQTLLVYDG MDGIGTTTTT HWADRSNEAG
LRTAVQRVPT PVEDNRMELK LNITDSELVF VEKTDQHDTN AVILKSTTVV SYRPFEVNKT
LSINLNNLEV FSCILGAEER TALSIIDPVT INMDVKKGVL EIQMQKQLCI RLSYHDVRMF
RQMLESLPKQ TKNARDHRQQ QQQQLERRIS DSGYSRGGSM DSTGAITTLT VNSRAVEKLV
HLGFRREDCL VALERCSHQL DEAALWLTQN KEPRRHDENR PGLMHSSSVG SAGSNAAGGG
GGASGGALNI SAIELKSPCI SICVIDDCRD ADVPLVELSL SKLDLRQELG HRTEPDAEAT
DPNVVAVAMD ALAATFSGHN GGRMVGVFAV DYYNRVLSGW EPMIEPWKLE AKWGYSLAID
TTAGDTSAAS AGGSTGNRLN MRVESNDTLR LNLTSTLIDL FALVRDNWMQ DYWNVETMEG
KSSNGTTSFR QRAPFIPFAI KNDTGVRLWY TTLISSELVS STRGRGGIVG SLPNVPPEAN
WTLVEPGGVA TFSYGTRNKA RHRDSHKVNL HQVAVRVEGW QEVGPVSVDR VGTYFRHARP
DLCSVAAATV SDYSQTLRAR IVFGVTMEGS AQKLITVRSA LRLTNKLDHP VLVKMEHLFG
HLNIRNWPET KTAILHANEL LHVPLTHVHA ILYFRPLLGS AIEEAMNSLT PASSSSLSSS
APGSQQASAS SDPRWTLLQR FDIPKTVGHG AGYQFTDRGI QWADAIEPGD EILQELRTCR
GPRDKTCRML LAIRKEPYPS RDVIHLPGHV ITILPPMRIH NLLPCDLLYR LPSGSHGRIA
SSETERITEV DIEQPIALSL TLDSYPNAGQ ITIPAGTYGS TTFDVRLFDL GGRMLRLAAT
ILVVRGRGVQ ISIGAPYWLV NRTGLPLVFR QDDLDTECAG QFGENEEARM ITPFMFAFSD
PGCSGSVTMR LGRRFGGSPN WCQPFKLEQG TQHRQLRGPS DTFIIGIEVR RARGKYGQTS
IVTFSPRYQL YNRSSYTLQV LQKCLVAGTT VYDPSASSSS SAYIEAVPGC HIPFHWPRLE
REHELCVRLP DVPECLWSGG IPIAGAGGLS LYINIRNVNG VMHFLRLETI LHGATYFMIF
SDAQALPPPI RLDNFSHVPI TFAQADAKTT FKTIVRPQCS IAYVLDEPTG APYLQLEAPG
GDYANCRLDG FEPFRLMYEN FIYIAFSQTF DDGTGVEEVR SQQLVLGVVD GRVLLVRKQA
GDRSQLWRMN NEKQLEHEGT SPPSEPGRKQ PRYVLDLEKP PQPMQYIALV VRPANRQRRS
TQTWHFTEDG RLMCEHSNMC VQARGGLFGL RAGSEAVLGM CVSDTKVLTR CGVPFEQAIE
RQKLRPGSGC LSVSYRMDGP IKSIQIRDVK AGGRAGDLLT LDSSWKHVSH IFASGAAARG
STSSEEAGHP ARKDIHEYHV QLKLRKGIGL SLISNQPCEE LAYVTLENLH MECIRTPAVN
SLDFSVGDMQ IDNQLFETSC PIMLYTVGGP SGTVEGISST ALQLNVKQLP SPNTNAVIFE
HFIVSIRPVA VYLEERLFLR LVKFFGFAKP TVDPTTLPDE TDYEAQKIVY KVLDSNVKRY
YFGDLRIIPA QIRLSFVTAS KLTAEFAEIK RNLGFTFIKF EDAVINFEQF AHRYHFETLD
AYLSAIRAHY KQELKWQAAS ILGSVDFLGN PLGFANDLSE GFSGLLLEGS ISSLVKNVTH
GISNSTAKLT ETISDGLGKV VFDDEHVETR QRILDVSGGG GSGGGTTGDH LVAGFRGFTF
GLLGGVTSIV KHTYQGTASD GLSGFITGLG KGLVGTVTKP VIGVLDLASE TANAVREQSK
GSNRILPERK RPPRTVTGAP GGLLPTYSYL QSTGQQYLFL INKRNFAEQF MAYEPCLLDT
KDSKMRLLVS AENVWGFSKN DETTMIVFHY PMGEIISCQP LTVQPQDQQS VSQGSGRSSG
GGGAGARKAA VTYIEFCLSL PSKSSLTPSA PEMVKRPRVR CQNEEIAKKI CYHVNFAKCI
YDEREQTLNI NTVIE
//
