ID A0A182NCF7_9DIPT Unreviewed; 4742 AA.
AC A0A182NCF7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR005321-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR005321-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR005321-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 7168.A0A182NCF7; -.
DR EnsemblMetazoa; ADIR005321-RA; ADIR005321-PA; ADIR005321.
DR VEuPathDB; VectorBase:ADIR005321; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1910..2061
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2224..2375
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2594..2744
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2936..3102
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2397..2418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..578
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3215..3284
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3486..3555
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4742 AA; 541102 MW; CF923C011E377242 CRC64;
MGDSLETTLP SMGSEQPPSV EAETVAIIDF DNFSNYLRKA ITVLLPEDDV KSFGPLNTAL
EDSVNQDCIR KFISDPQTQA LYIQRNCFKD DENEPPTEGE EEKDSITYYF GNDVHFTNQR
MASLVCIKRG ALIEADKSIH SQVRLINFSE GSPYETLHAF ISKTLAPYFK SYVKESGRAD
RDGDKMAPSV EKKLAELEMG LLHLQQNIDI PEVTLNINST VAQVVKKCAD EQRKAKITDF
GDRVQDSTFL NTLQNGVNRW IKEIQKVTKL DRDPSSGTAL QEISFWLNLE RALHRIQEKR
ESPEVALTLN ILKHGKRFHA TVSFDTDTGL KQTLAMVADY NPLMKDFPIN DLLSATELDK
IRQAVHSIFN HLRKIRNTKY PIQRCLRLIE AISRDLSQQL LKVLGTRRLM HIPFDEFERV
MNQCFEVFSC WDDEYDKLLG TLREIVKRKR DEHIKMVWRI SPAHKILQQR MEHMRKFRRQ
HEQLRTVIVR VLRPARQPSS AMSAAADGGV GGEGKQPYSL DTADANAIEE VNLAYENVKE
IECLDISKEG SEAWDAAIKR YEERIDRVEA RITAHLRDQL GTAKNANEMF RIFSRFNALF
VRPHIRGAIR EYQTQLIQRV KDDIEALHEK FKVQYPQSKS CRLSVVRDLP PVAGSIIWAR
QIDNQLTMYL KRVEDVLGRG WESHIDGQKL KADGDSFRAK LSTAEVFQDW ARKVQERNTG
ITGRIFSIET TRSRTGRGNT LRLRVNFLPE IITIYKEVRN LKSLGFRVPL AIVNKAHQAN
QLYPFAISLI ESIRTYERTL EKIEDRASII PLVAGLRKEV LGLISEGIAL IWESYKLDPY
VQRLSENVVA FQEKVEDLLV VEEQLDVDVR SLETCPYSAA TFADILSKIQ HAVDDLSLRQ
YSNLHVWVAR LDEEVEKKLA ARLQAGVQAW TDALTGNKKE LDLSMDTDAP TQPTIRPGGD
PQIQRAIHEI RITNQQMYLY PSIEEARFQI MQQLFAWEAI VTSQTRLQSS RYQVGLDKPV
LQTYRNLLTK LPNKPDPLEG AYAAIENQIG DVSSYVDEWL RYQSLWDLQA DMLYGRLGED
INLWIKCLND IKKSRTTFDT SDTRRAYGPI VIDYAKVQAK VTLKYDSWHK EALSKFGQLL
GNEMSTFHTK VSKSRSDLEQ QSIEAASTSD AVCFITYVQS LKKEMLVWDK QVEVYREAQR
ILERQRFQFP NNWLHVDNIE GEWSAFNEIM KRKDSAIQTQ VASLQAKIVA EDKAVETRTV
DFLNDWEKNK PTGGRTRPDD ALQQLHIFET KFSRLKEERD NVAKAKEALE LQESAIPNNS
TERMGVVLEE LQDLRGVWSE LSKVWAQIDE TREKPWLSVQ PRKLRQSLEA MMNQLKELPA
RLRMYESYEY VKKLLQSYIK VNMMIVELKS DALKERHWKQ LTKQLRVSWV LSDLTLGQVW
DVNLLKNESI VKDIILVAQG EMALEEFLKQ VRESWQNYEL DLINYQNKCR IIRGWDDLFN
KVKEHINSVA AMKLSPYYKV FEEEALTWEE KLNRINSLFD VWIDVQRRWV YLEGIFSGSA
DIKTLLPVET SRFQSISSEF LGLMKKVAKS PKVMDVLNIP AVQRSLERLA DLLGKIQKAL
GEYLERERTS FPRFYFVGDE DLLEIIGNSK NVARLQKHFK KMFAGVASIL LNEDNTVILG
IASREGEEVR FIKPVSTVEH PKINEWLSLV EKEMRFTLAS YLAQAVQDIK QFKDIIDTQK
YMEWCDKYQA QIVVLAAQIL WSEDVENALQ QTSEGNGNGN GKDKTPLHRV LGTVEATLNV
LADSVLQEQP ALRRKKLEHL INEFVHKRTV TRRLIAHGVN NPKSFHWLCE MRFYFDPRQT
EVLQQLTIHM ANARFYYGFE YLGVQDRLVQ TPLTDRCYLT MTQALEARLG GSPFGPAGTG
KTESVKALGN QLGRFVLVFN CDETFDFQAM GRIFVGLCQV GAWGCFDEFN RLEERMLSAV
SQQIQTIQEA LKSQQDANRD AQSITVELVG KQVRVSTDMA IFITMNPGYA GRSNLPDNLK
KLFRSLAMTT PDRQLIAEVM LFSQGFRTAE KLACKIVPFF KLCDEQLSNQ SHYDFGLRAL
KSVLVSAGNV KRDRIMKIKD TKKQQGEENI DEASIAENLP EQEILIQSVC ETMVPKLVAE
DIPLLFSLLS DVFPNVGYTR AEMKGLKDEI RKVCSEEYLV CGEGDEQGGA WMEKVLQLYQ
ISNLNHGLMM VGPSGSGKSS AWKVLLKALE RFEGTEGVAH VIDPKAISKE ALYGVLDPNT
REWTDGLFTH ILRKIIDNVR GEINKRQWII FDGDVDPEWV ENLNSVLDDN KLLTLPNGER
LSLPPNVRIM FEVQDLKYAT LATVSRCGMV WFSEDVLSTE MIFENYMSRL RHIPLEDGEE
ESFSGQSKSS EKEDEVTPAL QTQREIAALL QPYFTSDGLV VRCLEYAMGQ EHIMDFTRLR
ALSSLFSMLN QGARNVLTFN QQHPDFPVPP EQLEQYIPKL LIYSMLWSFA GDSKLKVRSD
LGDFLRSITT VTLPAQGGNP IIDYEVNIQG DWVPWSNKVP VIEIETHKVA APDVVVPTLD
TVRHESLLYT WLAEHKPLVL CGPPGSGKTM TLFSALRALP DMEVVGLNFS SATTPELLLK
TFDHYCEYRK TPNGVVLAPV QLGKWLVLFC DEINLPDMDS YGTQRVISFL RQLVEHKGFY
RAADQSWVSL ERIQFVGACN PPTDPGRKPL SHRFLRHVPI IYVDYPGETS LKQIYGTFSR
AMLRLMPNLR GYAEPLTNAM VEFYLASQDR FTQDMQPHYV YSPREMTRWV RGICEAIRPL
DNLPVEGLVR LWAHEALRLF QDRLVEESER RWTNENIDLV ATKHFPSVDR DKSLARPILY
SNWLSKDYMP VNRDELRDYV KARLKVFYEE ELDVPLVLFD EVLEHVLRID RIFRQPQGHL
LLIGVSGAGK TTLSRFVAWM NGLSIFQIKV HNKYTSEDFD EDLRCVLRRA GCKDEKIAFI
LDESNVLDSG FLERMNTLLA NGEVPGLFEG DEYTTLMTQC KEGAQREGLM LDSSDELYKW
FTQQVMRNLH VVFTMNPSTD GLKDRAATSP ALFNRCVLNW FGDWSDSALF QVGKEFTIRV
DLEKPTWSAP DFFPAVCPLV SNTPSHRDAV INSCVYVHQT LHKANARLAK RGSRTMAITP
RHYLDFIHHF VKLYSEKRSD LEEQQLHLNV GLNKIAETVE QVEEMQKSLA VKSQELQAKN
EAANAKLKQM FKDQQEAEIK KVQSQEIQHQ LAEQTVKIEE KRKDVMADLA QVEPAVIDAQ
AAVGNIKKKQ LAELRTMANP PLPVKMALES VCLLLGEDDR GGDWKAIRAI MVKDSFIASI
VKLDTSHITQ VLGNIKAAVK SIKKQHLVEV RSMANPPAVV KLALESICLL LGENASDWKS
IRAVIMRENF INLIVSNFST EDITDEVREK MKSKYLSNPD YNFEKVNRAS MACGPMVKWA
IAQVEYADML KRVEPLREEL SSLERQAETN IKHGKEVKEL IAQLEQSIAA YKEEYAQLIS
QAQAIKTDLE NVQAKVDRSI ALLKSLVIER ERWEATSETF RSQMSTIVGD VLLSAAFIAY
GGYFDQHYRS NLFSTWCQHL QAANIQFRAD IARTEYLSNP DERLRWQANA LPTDDLCTEN
AIMLKRFNRY PLIIDPSGQA TEFIMNEFKD KKITKTSFLD DSFRKNLESA LRFGNPLLVQ
DVENYDPILN PVLNRELRRT GGRVLITLGD QDIDLSPSFV IFLSTRDPTV EFPPDICSRV
TFVNFTVTRS SLQSQCLNQV LKAERPDIDE KRSDLLKLQG EFHLRLRQLE KSLLQALNDA
KGKILDDDSV ITTLETLKKE AADIGQKVEE TDKVIGEIET VSQQYLSLSQ ACSNIYFTMD
SLNQVHFLYQ YSLKMFLDIF STVLHNNPKL EGKTDHTARL LIITSDLYRV CYDRVARGML
HADRLTFAIL LCRIHLKGTS EPNLDQEFNF FLRNKEGLVA SASHVDGVSA EQLESVTRLA
TRLSIFRKLL DKIKSMPELT AWLQQGSPEQ NVPVLWDESK ALSAVSASMH QLLLIQAFRP
DRVIAAAHLF VSTVLGEDFM PQAEKELDFS TCVEKEFNSN TPALLCSVTG YDASSRVDDL
AAELNKQISS IAIGSAEGFN QAERAINMAC KSGRWVLLKN VHLAPQWLVQ LEKKLHSLQP
HSGFRLFLTM EINPKVPVNL LRAGRIFVYE PPPGIRANLL RTFSTVPAAR MMKQPSERAR
LYFLLSWFHA IVQERLRYVP LGWAKKYEFN ESDLRVACDT LDTWIDATAM GRTNLPPEKV
PWDALVTLLS QSIYGGKIDN DFDQRLLASF LSKLFTAHSF EAEFALVANV DGVAGGPNGQ
RHITMPDGTR RDHFLKWIEA LADRQTPSWL GLPNNAEKVL LTTRGTDLIS KLLKMQQLED
DDELAYSNDE SLDTMQTRQE DGRPSWMKTL HNSALTWLEL LPKSLATLKR TVENIKDPLY
RYFEREVSSG AKLLQTVVSD LQDVVLICQG EKKQTNYHRT MLSELVRGIL PAGWRRYTVP
AGCTVIQWIT DFSQRVQQLQ KVSTLVSQAG AKELQSFPVW LGGLFNPEAY ITATRQCVAQ
ANSWSLEELT LNVTITETGS DGYDNLKDSS FGVSGLKLQG AQCKNNQLLL TSAIMTELPL
TLLKWTRIDS EAARATKLTL PVYLNSTRVE LLFTVDMTVA PGQDPHSFYE RGVAVLASTA
LN
//