GenomeNet

Database: UniProt
Entry: A0A182ND92_9DIPT
LinkDB: A0A182ND92_9DIPT
Original site: A0A182ND92_9DIPT 
ID   A0A182ND92_9DIPT        Unreviewed;      5078 AA.
AC   A0A182ND92;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   28-FEB-2018, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:ADIR005606-PA};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|Proteomes:UP000075884, ECO:0000313|VectorBase:ADIR005606-PA};
RN   [1] {ECO:0000313|Proteomes:UP000075884, ECO:0000313|VectorBase:ADIR005606-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884,
RC   ECO:0000313|VectorBase:ADIR005606-PA};
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|VectorBase:ADIR005606-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|VectorBase:ADIR005606-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
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DR   VectorBase; ADIR005606-RA; ADIR005606-PA; ADIR005606.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075884};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075884};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4406   4426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4593   4614       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4683   4705       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4873   4895       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4951   4974       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1218       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1427   1652       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      460    480       {ECO:0000256|SAM:Coils}.
FT   COILED     3750   3770       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5078 AA;  574451 MW;  72593D814EC606F3 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
     SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NDLSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSLDQG
     QNIVVYEGGS VMSQARSLWR LELARTKWAG GFINWSHPMR IRHLTTGRYL GVNENNELIL
     MSRDQATTSQ TAFVLRLEKD DQKVVLEDKD LEIIGAPIIK YGDSTVIMQH YESGLWVSYK
     SYETKKKGVG KVEEKQAILH EEGKMDDGLD FSRSQEEESR TARVIRKCSS LFTKFISGLE
     TLQENRRHSI FLQTVNLGEM VMCLEDLINY FAQPEDDMEH EEKQNRLRAL RNRQDLFQEE
     GVLNLILEAI DKINVISSQG FLASFLANDE SGQSWDMISG YLYQLLAAII KGNHTNCAQF
     ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
     PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTG LVDHVASIRP NIFVGRVEGS
     AIYQKWYFEV TMDHIEQMTH MTPHLRIGWA NTAGYVPYPG GGEKWGGNGV GDDLFSYGFD
     GMFFWSAGRR TCVVPREISE PFIKKGDVIG CTLDLSVPII RFTFNGEPVQ GCFTDFNLDG
     MFFPVMSCSS KLSCRFLFGG DNGRLKFNPP PGFSPLVQCL MPHQNLSLDP CFYFGNLNKN
     VLAGPWMVED DTAFVPQPVD TSTVTLPSSV ETIKDKLAEN IHEMWALNKI EAGWTWGERR
     DDVYRIHPCL TSFEKLPAAE KRYDCQLAVQ TLKTILALGY YISMDRPPAR IRPIRLPNDP
     YMQGNGYKPA PLDLSAAVLT PKMEELVDQL AENTHNLWAK ERIQQGWTYG LNEDSENLRS
     PHLVPYSKVD EAIKKANRDT ASETVRTLLI YGYNLDPPTG EANEALAAEA LRQKFAAYRT
     YRVERTYAVT SGKWYFEFEV LTAGPMRVGW ARADCNPGTM LGSDDASWAF DGYNARKMHL
     HTLEDFGRRY KMGDIIGCFI NVHEKSMSFS LNGELLMDAL GGETTFADVN APEGVGFVPA
     CTIGIGQKAR VVYGQDVDSL KWFTTCGLQE GYEPFCVNMK RPVTHWYTKD QPIFENTDEI
     PECKIDVTRI PGGADTPPCM KISHNTFETM EKANWEFLRL SLPVTCANTF ISEQEKMRRW
     EEIRMRQHRL MTEVDHSAPA HFDHIMRSGF TMNDIKGLHR NYSEDAAEAD EMMRNGPRRP
     SRHQTRGGLS PPGIEINGEA TSDGELNAYS DNELDGAGDE RKKRGRSPFR LFGKKRDQSK
     DKLKDRRTPE PEPRKSNLKV TQRGQATRLS NSDLRAQPPM TPERKGLASN QVESFGNEVY
     DAECLRLINE YFYGVRIFPG QDPTHVYVGW VTTQYHVHSK EFGQNKVRHA AIYVEDENEK
     TIEIVNRQSC YMVRADELFN EVTQDSSGKG ASQGMFVGCF VDTATGTIRF TCEGKETSHV
     FLMEPDTKLF PAIFVEATSK EILQIELGRT PTTLPLSAAV LPTSDKHINP QFPPRLKVQC
     LKPHQWARVP NTALQVHALK LSDIRGWSML CEDPVSMLAL HIPEEDRCID ILELIEIDRL
     LQFHAHTLTL YSALCYQSNY RAAHALCSHV DQKQLLYAIQ SEYMSGPLRL GFYDLLISLH
     LESHATTMEV CKNEYIIPLG SDLRELYIDP EMCHSLRSLQ TLSVRPEMNM TEIAPTPSQS
     NMPTLVAPDS SSEPIPAIDS LYSPRFPLEV VREFVMSALQ EAVQINQVHN RDPIGGSNEN
     LFLPLIKLID RLLLVGVITN EDVEKLLIMI DPETWDPSFE KEGKDEHRKG LLTMKMAEGA
     KLQMCYLLHH LYDVQLRHRV ESIIAFAHNY VGDLQQDQLR RYIEIKQSDL PSAVAAKKTR
     EFRCPPREQM NAILGYKNLE EDDLENASCG PDLRSRLIEF HEKLMGKVSL NALQEPEEPE
     TDKLEEGRPG ALKKLYNFIN AVKELEEDPK EPVEEEKKTP EEVFRKVLIK QIVSWAEESQ
     IENPKLVREM FGLLVRQYDT IGELIKALNK TYVINSKTKG DVANMWVGLS QIRALLPVQM
     SQEEEELMRK RLWKLVNNHT FFQHPDLIRI LRVHENVMAV MMNTLGRRAQ AQSDAPVQTA
     DGEESAPKEK DTSHQMVVAC CRFLCYFCRT GRQNQKAMFD HFDFLLENSN ILLSRPSLRG
     STPLDVAYSS LMENTELALA LREHYLEKIA IYLSRCGLQS NSELIERGYP DLGWDPVEGE
     RYLDFLRFCV WVNGESVEEN ANLVIRLLIR RPECLGPALR GEGEGLLKAI IDANKMSERI
     SERRKMQDEA EGTITGLNFS HPLPEGDDDE DYIDTGAAIL CFYCTLVDLL GRCAPDAAVI
     EQGKNESLRA RAILRSLVPL EDLQGVLSLK FTLTNPALGE DRPKSDMPSG LVPGHKQSIV
     LFLERVYGIE TQELFYRLLE DAFLPDLRAA TMLDRSDGSE SDMALSMNRY IGNSILPLLI
     KHSKFYNEAE NYASLLDATL HTVYRMSKNR MLTKGQREAV SDFLVALTSA MHPAMLLKLL
     RKLTIDVSKL SEYTTVALRL LTLHYDRCAK YYGTTGSGQA SQFGASSDEE KRLTMLLFSN
     IFDSLSNMDY DPELFGKALP CLIAIGCALP PDYSLSKNSD DDLYGKPTGG GPDQPHYNPQ
     PIDTTTVQLT NDLNQIVQKF SEHYHDAWAS RKLENGWTYG DQWSDANKTH PRLKPYNTLS
     EYERERYREP VRESLKALLA LHWRIEHSEG DVPLSNRGSM RRQSKPNLEL QGDTGSPFNY
     NPHPVDMTNL TLSREMQNMA ERLAENSHDI WAKKKNEELN QCGGAIHAQL VPYDLLTDKE
     KRKDRERSQE FLKYLQYQGL KLHKPSRGQT EEPGMTTAAI ELRFAYSLLE KLISYSDRAT
     INMKLLKPSS TFSRRSSFKT CSRDIKFFSK VVLPLMEKYF STNRNYFIAI ATATNNVGAA
     SLKEKEMVAA LFCKLASLLR YRLAAFGADV RITVRCLQVL VKSIDAKSLV KNCPEFIRTS
     MLTFFNNTAD DLGQTIVNLT EGKYDRLRGT HLKTSTSLAY VNQVILPVLT SLFDHLAACD
     YGSDLLLDEI QVASYKILSA LYTLGTDMSL TRDRKYLKTE LERHKPALGS CLGAFSSCFP
     VAFLEPHANK HNPFSLLNRI ADTSLEAQDI MSKMESCMPT LESILSEVDQ FVESEKTYQD
     AQHIIDVILP LLCSYLPFWW NQGPDNVSPQ TGNHVTMVTA DHMNHLLKNV LKMIRKNIAN
     ENAPWMTRIA TYTQQIIINS SEELLKDVFL PLAERVKKRC DSMFHKEESL RGFLKSSTDD
     TSQIEAQIQE DWQLLVRDIY SFYPLLIKYV DLQRNHWLKD NVAEAEELYN YVAEIFNVWS
     KSQYFLKEEQ NFISANEIDN MALIMPTATR RSAAVSGDMP ASGGKVKKKK RSRDKKRDKD
     KEIQSSLMVA CLKRLLPVGL NLFAGKEQEL VQHCKDRYLK KMPEYEVIEF ARTQLTLPDK
     LDPADEMSWQ HYLYSKLGKK EQIVQDTIEK ADKKPENKIE DTVERIVAMA KVLYGLHMIH
     QFPHRACNIF ARSYSELWLE DENVGQEVMI EDLTQTFEDA EKKKKDEEEE EGKPDPLTQL
     VTTFCRGAMT ERSGALQEDP LYMSYASIVA RSCGEEEEEG GDEEEGAGGE DEGGASIHEQ
     EMEKQKLLFH QARLANRGVA EMVLLHISAS KGLPSEMVMR TLELGIAVLR GGNIDIQMGM
     LNHLKEKKDV GFFTSIAGLM NSCSVLDLDA FERNTKAEGL GVGSEGAAGE KNMHDAEFTC
     ALFRFIQLTC EGHNLDWQNY LRTQAGNTTT VNVVICTVDY LLRLQESIMD FYWHYSSKEL
     IDPAGKANFF KAIGVASQVF NTLTEVIQGP CTQNQQALAH SRLWDAVGGF LFLFSHMQDK
     LSKHSSQVDL LKELLNLQKD MITMMLSMLE GNVVNGTIGK QMVDTLVESA SNVELILKYF
     DMFLKLKDLT STPSFMEIDS NGDGWILPKD FREKMEQQKS YTPEEIDFLL ACCETNHDGK
     IDYIGFVDRF HEPAKEIGFN LAVLLTNLSE HMPNEPRLAR FLETAGSVLN YFESFLGRIE
     IMGSSKRIER VYFEIKEANI EQWEKPQIKE SKRAFFYSIV TEGGDKEKLE AFVNFCEDAI
     FEMTHASGLM ASDDDGGTVR RDQSFTYISE EEEERAARDP IKRTIQAVKD GLSYSVYMIS
     PSNIKHQITV LQSKSFPEIV VGFFKMIFYA FYYSGFGVSV VIRYLVNILM SLMRGPAQEE
     EEPIPEAEPS LRALPPLPLE EPPGTVQAFG LDISKEENGQ YRMAPHESPA LSPSSSIEET
     GESSPEDGAG GELTGEGVAP GEQMTLVDLL GGEAAKRAAQ ERTEAQKAQE ATLASIEAES
     KKASAETKEP AAVHQIDFSK YTKKCVSYLA RNFYNLKYVA LVLAFCINFM LLFYKVTTFG
     DEEEGEGSGE SLMGLGSGLG SGLGILDTGS GGGEGGSGDG EGEEDDPLEK VEVDEDFFYM
     EHVLRVAAML HSLVSLAMLI AYYHLKVPLA IFKREKEIAR RLEFDGLFIA EQPEDDDIKS
     HWDKLVISAK TFPVNYWDKF VKKKVRQKYS ETYDFDSISN LLGMEKTAFA AQEANEGGGF
     FHFIANIDWR YQIWKAGVTI TDNSFLYSLW YFSFSVMGNF NQFFFAAHLL DVAVGFKTLR
     TILQSVTHNG KQLVLTVMLL TIIVYIYTVI AFNFFRKFYV QEDDDGEEGD RKCHDMATCF
     VFHLYKGVRA GGGIGDEIGD PDGDEYEVYR ILFDITFFFF VIVILLAIIQ GLIIDAFGEL
     RDQLESVKED MESNCFICGI GKDYFDKVPH GFDTHVAQEH NLANYMFFLM HLINKPDTEY
     TGQETYVWNM YQQRCWDFFP VGDCFRKQYE DELGGGGS
//
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