ID A0A182NDI8_9DIPT Unreviewed; 902 AA.
AC A0A182NDI8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR005702-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR005702-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR005702-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR AlphaFoldDB; A0A182NDI8; -.
DR STRING; 7168.A0A182NDI8; -.
DR EnsemblMetazoa; ADIR005702-RA; ADIR005702-PA; ADIR005702.
DR VEuPathDB; VectorBase:ADIR005702; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13717; PBP2_iGluR_putative; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF403; IONOTROPIC RECEPTOR 8A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 354..754
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 362..432
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 902 AA; 101682 MW; D765324CF6731147 CRC64;
MLPQVIVHEP EQTNVPSTAV AAIKKVLTKV KGITVQDYYI EYDRNRLQFV DNEQRVSLLL
DVTWIDSKYI SGAAREFGVP YFHVDLSVQT YVKLMEAFLL ARAGNDVVYI LPNLQEVDAT
IYLLITDSYL RAIVFGELDE DTVGRITNIR PYPAFYAVVA GTAQMNAILQ KAIDGGLVRK
PEKWNLLFTD MESDKFAYAD SYPEMNRLHL DVSTCCILLQ QLLPCICPDP FDPMEAHLEN
VLELLLQWSV EVPLPVVHAL NCTPEPDPEP YERATAAQDA LQNKMGSMAQ FWITQESDMV
RPNLNLSIIT SPTGQNSTSP LQPPPAATTI GSLVQGEVVM ASNETLRPSK RFFRIGTTES
IPWAYRKRRP TGEILRHPAT GEPIWEGYCI DFLHELSVVM NFDYDLVAPR NGTFGMRDAD
GKWDGLIGEL VVGEIDFAIA ALKMTAEREE VVDFVAPYFE QTGILIAMRK PVRETSLFKF
MTVLRLEVWL SILLAIVATA VMLWLLDKFS PYSAKNNKEA YSYECRKFTL KESFWFALTS
FTPQGGGEAP KALSGRTLVA AYWLFVVLML ATFTANLAAF LTVERMQTPV QSLEQLSRQS
RIKYTVVKGS DTHDYFRNMK HAEDVLYQMW RNLTLSSGND QAQYRVWDYP IKEQYINILS
AIETAEPVAT AADGFRRVNE RLDADFAFIH DSAEIRYEIS RNCNFTEVGE VFAEQPYGIA
VQQGSHLQDE LSFFILELQK KRYFESITAK FWNNSARGQC PNTDDSEGIT LESLGGVFIA
TLVGLALAMI TLLGEVIYYR RKESSRNIVK VAPFGTADGA LDQRDGRRFA LKEKSIAAVR
HLLDLGTTPP KVRVGQQQKE HLNAGKKKAI PKEVTIGSKF ISAAEKQQKL SYIAIMPRNP
IH
//