ID   A0A182NDN0_9DIPT        Unreviewed;       969 AA.
AC   A0A182NDN0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=MBD domain-containing protein {ECO:0000259|PROSITE:PS50982};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR005744-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR005744-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR005744-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182NDN0; -.
DR   STRING; 7168.A0A182NDN0; -.
DR   EnsemblMetazoa; ADIR005744-RA; ADIR005744-PA; ADIR005744.
DR   VEuPathDB; VectorBase:ADIR005744; -.
DR   OrthoDB; 685587at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   CDD; cd00122; MBD; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   PANTHER; PTHR15739:SF5; LD23158P; 1.
DR   PANTHER; PTHR15739; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF01429; MBD; 1.
DR   SMART; SM00391; MBD; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50982; MBD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          106..176
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   969 AA;  105093 MW;  874E5E22F6C6F7B1 CRC64;
     MAQQQRLHQR EALAGGMLHH QHNQQLNIKQ DPDDGEEDES KSMNVRPSVG EKRRYSELMC
     ESDEDDFAGF DEDAASSEND MDMLNNTSLS EANKSLAKKK INVPINTQDD IYKAPFKYGW
     KRELVYRANM DGNSKDKGEV YYITPTGKKL RTRNDIVASL HDDLTMDNFT FVKEPVGGTP
     EEETIRSAKS YSNVPKRSTP GTAQSMTLDT SADLGKRIPK PKMPKGASPP PPSSYARMGS
     LGQMPLSKSS GGNTQISPKS NNMHGASGTS KANEHIPGVP GKQPSSKIGG KNKVEPCTIQ
     CIPAMGMIPQ LQCMVCYCMY HPECAHATTA EALARRFTCK SCMEDSVTAE MQYQQHQQTY
     KESFGKFGVS GNGIGSICST DTTKPPPPTA ANNGGSLSSS KTVAKPAANT GGTATAKEKT
     KRSQQQLVAG TKIATAAAND SAPVAGTHGL SNVAAAKDIP PQDVLVIGNH EYVVVPKGKA
     AAAVKSKKSS SKTPNLQPQA TTKVADEGRK MTNNAASGGS GSTRPTNSAI DRLSDDESLG
     VGTQKHANSA AATQNGTGRD PSNFLSDVSA GYTCLMLSFE YLKVQELLRA CSVCRMWNHL
     GNHPRFWKTV RMKNSYISDW AGMIGKLRQN GTKHLDLRKV LNVGSNDEMW ESFIDHIGEA
     DQIEVVDLCR CSSTVVGNLL RSNPNLRVVN ALAIKNDPID FVNFEHGVQL EELRLKSSAA
     ISLDGDLHQL AALQNLKHLS LTSISKLGST SIEALGSLVL LESLELGECT EMGTNLAEIL
     PNLTALKRLR LEKGQENFEM FTILSGISRV ASLTQLELIN CDVKLGFDKH IANCTNIRKL
     LLIPTYVSQS AATNRMVLKG VMKLHQTLET VVWAITKELL RVTELYIDAN VNDADSPMGG
     SVPILKPVPG SDDPPAAIGT SQPDLPEEVE IVPLKRVKSI LERKVPNTKV QILKIPFSNT
     WKQTMCDTV
//