ID A0A182NEE8_9DIPT Unreviewed; 624 AA.
AC A0A182NEE8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR006013-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR006013-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR006013-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A182NEE8; -.
DR STRING; 7168.A0A182NEE8; -.
DR EnsemblMetazoa; ADIR006013-RA; ADIR006013-PA; ADIR006013.
DR VEuPathDB; VectorBase:ADIR006013; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07887; RHD-n_Dorsal_Dif; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR011363; Dif.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF20; DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PIRSF; PIRSF001716; Dorsal; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
FT DOMAIN 6..186
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 322..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68133 MW; 1FA1A069C8E74837 CRC64;
MPPVATQRPY VEITEQPHPK ALRFRYECEG RSAGSIPGVS TTADHKTFPG IQVHGYRGRA
VVVVSCVTKE SPDHKPHPHN LVGKEGCKKG VCTVEINSTT MSYTFNNLGI QCVKKKDVEE
ALRMRQEIRV DPFRTGFAHA REPGSIDLNA VRLCFQVFLE GQQRGRFTEP LAPVVSDIIY
DKKAMSDLII CRLSDCSAPV SGGKEIILLC EKVVKEDIRV KFFEKKGNVT VWENYAEFSH
TDVHKQVAIS FRTPPYKAVD ISDPVRVYVQ LERPSDSTVS DPRDFQFIPL DSVELRRKQR
KLGSSNVFLP VASPQGTVVT GNIPNLSQLD PTGGPSASTS GLPQGMYHYS NANPFQQMAK
KEIKHEPGDS PNHNPSNQFQ LQAMQLLPNN QSISPGPDRS PSTLTPSPVI GGPISPMDPG
NVTPTPPVYP TQAVSVGNPF GAFGTFGNTT TPEQQPNATV SIFETNLPGP SNGWIQPIPL
PNQNGPSQIH QSFNLGNFGS LPLTADPLLS IDLTTAAPLT IQPNVGSTSI GSENNLMNLD
LYNLETLNSS EFRSVLGALS TSDLNRLEQA ANMQTSGNYQ HQSASSLRAL LATQQQQGQP
LNDRNDNDED LTDSFTKLST NDLN
//
