ID A0A182NK55_9DIPT Unreviewed; 898 AA.
AC A0A182NK55;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR008035-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR008035-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR008035-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A182NK55; -.
DR STRING; 7168.A0A182NK55; -.
DR EnsemblMetazoa; ADIR008035-RA; ADIR008035-PA; ADIR008035.
DR VEuPathDB; VectorBase:ADIR008035; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763}.
FT DOMAIN 232..381
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 700..844
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 437..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 99858 MW; 52C259E5CE6AC45E CRC64;
MSEEADTPML PATTAESRKI NAIDKETVHR ICSGQVVLNL AIAVKELVEN SLDAGATLVE
VKLREHGAEL VEVSDNGSGV EERNFEGLTA KYHTSKLKEF TDLESIETFG FRGEALSSLC
ALSDMVITTR HCSSPHATKL ILNHEGRIGT RTPCARAVGT TVSLTNLFAT LPVRKKEFQR
NIKREFLRMC QILQAYCLVS VGVRIICTNH LAKGAKTTVM STHGSTRVLD NITALFGTKQ
TAELMRLVPA IGSNGRIEDL ESSDFDESIA LTQEEVDNFN LSRYKIEGYI SSCAHGSGRG
SRDRQFYFVN SRPCEPKQIS KMINDAYHRY NVHQQPFVYL NLVLDRSDVD VNLTPDKRQV
LVNNEKILML AIRKSIKKTF GSIPSSFKMQ NLNLSDSSRL MNISVHSEQD GEEGGSEDDF
LAVSSSDKCA AGDLQFTFQP PKTNAGSGAG GGGLKRKRST TSNGLQKMID FLNITKIPQS
KNAMDDSLTD RSLDEEELPI LKQPKSEENP YNLTILNGPP PDGKCQEAKE SVRVIRCTNG
STVNAKLPEE NAPSASESNA PGTSSQESVT ELVALMSCDA IPAIKRESSN ESILSLEQFI
APVKRESSGQ SCASPILIDD EPTEEETAMR NRNHQQLSVT RESLEQLLVR ERTLKSNADE
RRSELTRLRF KRKINPSSNK AAESELQTEI TKADFGAMQI IGQFNLGFII VRLGDDLFIV
DQHATDEKYN FENLQRTTVL QNQRLVVPQL LELTAVNEMV LVDNLDVFEM NGFKFEVDGA
APTTQKVRLI AKPYSRNWEF GKEDIDELVF MLQDAPNTVC RPSRVRAMFA SRACRKSVMI
GTALSVREME RLVRHMGEIE HPWNCPHGRP TMRHLVNLAM ISQIDESEPT DKGESSIE
//
