ID A0A182NK93_9DIPT Unreviewed; 1726 AA.
AC A0A182NK93;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Down syndrome cell adhesion molecule {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR008073-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR008073-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR008073-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 7168.A0A182NK93; -.
DR EnsemblMetazoa; ADIR008073-RA; ADIR008073-PA; ADIR008073.
DR VEuPathDB; VectorBase:ADIR008073; -.
DR OrthoDB; 4503820at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF48; MYOPALLADIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 5.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 8.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1486..1507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..190
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 194..281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 287..380
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 385..471
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 476..569
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 572..659
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 669..764
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 773..867
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 872..978
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 983..1078
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1082..1177
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1179..1267
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1269..1362
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1363..1460
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1546..1669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1683..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1571..1585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1726 AA; 192206 MW; 73FCE3CDCE556DDA CRC64;
MLRVSSSISS NITYVPSYIQ DYVVVTAWVQ DSGVHLYPNT DIGGKYIVLS NGDLYINNAG
ASDAYKTYSC RTVNRLTGEI QISTYPGRVI VTEPKGLVQP RINVEKHSLK HVVVNAPVTL
PCVAQGHPVP TYRWFKEVKD QILPLQLNER ISIVSAGLLK IAKARLEDSG KYLCWVNNTA
GEETIQVSLT VTAPLTAHLQ PQVQTVDVGK DAQFQCIISG FPAHEVLWMH NGKPIVRDSR
IEIYTDAPRI VIKSVQKEDQ GMYQCFVANE WEQIQSTAEL QLGDATPELL YWFSEQTLQP
GPTVSLKCVG TGNPPPQFTW KLDGFPIPDS PRFVVGQYVT IHDDVISHVN ISNVKEEDGG
EYTCVAQNSI GKVSHSAKVN IYGLPYIREM PKITGVSGHD LIIKCPVAGY PIDKIHWERD
GQTLPINRRQ RAYNNGTLII EQLQLAEDAG TYTCMAQNKQ KQTARRNVEI QVIVPPKIMP
IQAMTNMLRE GMRAAISCQI LEGDLPVNFR WERNGKPVLG TGNEVIRRLD EYSTSLVIEH
ITSEYSGNYT CIASNVAGSE SFTVPLTVNV PPKWILEPKD SSAQAGQDVA LHCQAGGHPQ
PTVTWKKAIG NTPGEYKDFL YEPNVSLHTN GTLQFRKIAK DSQGHFLCEA KNSIGSGVSK
VIFLKVNVPA HFNTKNKQIT SPRNKQIHIQ CNVQGDNPID IKWKMQSSQQ QLDESLDNRY
NIREQVLDDG MVSELGISHT YRQDTGVYIC QASNAFGQDE MSIHLVIQEV PEAPKNLRIN
SQQSRTLQLS WSQPFAGNSP IEKYNVEYKL VTEPWQSAEH ITVAGTQTVI TLQNLKPAKA
YHLRISAENK LGASEYSEVI QVTTLEEVPS GPPLNIKGEP KSSTEIFLSW EAPDRDQWNG
NLLGYYVGYQ IASSPNDREI NPTQGFNFKT VEVRSHFGGE TTLQNLNKCT TYNIVVQAYT
SQGSGPPSKE ISLGTLEDVP SSAPDSPKCD VLSSTSIYIT WSPPPVDGQN GKIRGYKVSY
IEMDDLYEKE PYTSKTNNQY LTLESLKKFT NYTFWVLAFT KVGDGVRTNP FHCITQEDVP
SAPSALKAVP SSSTKVIISW LPPTHRNGVI TGYTFYMSLV DGGRDEGTHK RSLVPYAESH
ETVRLQEHAT YQFWLTASTK VGEGEKSEMI TVPPNNKVPA RIVSFSQEIV TPWKETLILP
CRKVGVPAPV TIWRQDDQAM DTGTRKLIAK NGTLYIKDCQ HSDAGNYTCS VENTWGRDEI
VYRIRIRVPP DPPTLTIVNT YTDSLLLEWT DNRNGGSPVL GYVINYKREN GDWEELQIDS
KTNTHLLVNL WCGTRYQLYI TAYNKIGTGL PCDIVHSHTK GLPPVQPKHS QMITNNSTSV
TCWLDSWGDG GCGILHFSIE NRQYGRPQWN MIASHVEATE RIFTVTDLQP ATKYQLRVTA
YNNAGATMAV YNYTTLTAQG VMVYPDITNP VSPHMGENPF YANFKVILPL CLSILILFAL
VAAGLLIRKR KLNNQNRIPS TSMSESPSIA NIQNKHNRDQ QYLAVRAQQA SRNSNSVDSG
SYKAEGNEYD TLGSESDNDI ASRSNQSNYR HHRDTQDETS SSSENSPSSI SRKSKPPYPP
RKSAKAQSQN LPKRHVRSSS GYSSHNEETT FSISNYPNYS DHITPPARFS DLLGRDATLA
VSSVNPSSLG SATEIGSNVV GKKSSNHSPR PRANQKLQRE AFQINV
//
