ID   A0A182NNT2_9DIPT        Unreviewed;       783 AA.
AC   A0A182NNT2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS00028};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR009317-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR009317-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR009317-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182NNT2; -.
DR   STRING; 7168.A0A182NNT2; -.
DR   EnsemblMetazoa; ADIR009317-RA; ADIR009317-PA; ADIR009317.
DR   VEuPathDB; VectorBase:ADIR009317; -.
DR   OrthoDB; 3088584at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18989; LGIC_ECD_cation; 2.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   PANTHER; PTHR18945:SF943; NICOTINIC ACETYLCHOLINE RECEPTOR BETA 3 (DBETA3) SUBUNIT; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 2.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        226..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        291..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        577..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        639..660
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        761..779
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          261..281
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS00028"
FT   REGION          696..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..721
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  89656 MW;  B91CC41039A138E3 CRC64;
     MIWQVDYAVA IDCDGEPTSI DGKLRKKLLC SNYDKSQRPV KDHTTGVNIT LLMNVKNYYL
     SETRPGLYLS VWMTFDWRDE FLTWSRAEYG LDKLTIASDD IWRPSIVTYN ERSVGTADKT
     CHNFECEVKL NGNVSCTSPC SYEVMCNSNN ADWPFDVMSC SLYLTSWLEK ANKLHISDRS
     NVSLQYLAMA HSSWKLLLAN TTALAYDMEN DPFTLLKYSF KFERHMGVYS AILTPGFLMI
     AVSLAVLWLN SGCNERLYIL CATCMGHFTY TQYIYWHVPY HGEDVPKLRN MILIFFRDSL
     FINMFMLVFT IILRHTVPKT DRPERLVDKL AFRVAATSFG RVLLQPIDPL GTPKVDENGA
     VNCDASDDPL TKEAKLLRNL FCFNYDKSER PVKNHNTAVN VTASMHVQNY DVSERESILH
     LYVWMSLSWR DEYLNWDRTE YGIDKLIVDS SELWRPTFVA FHNLKSGNGD SACASHPCEV
     NQTGNVLCVP PCQYEALCVR NTVNFPFDDL KCTMFLGTWL EDFNQINISR ISNVTTRHIE
     VQHTEWKLQS AVILHIFLPD NTSYPALEYI FTLERHVAIY GAILTPGFLM VVINLAVLWM
     NCGNNERLYI LCATCMGHFT YMEYLYWRVP YHGENVPKIL LFFRDSLIIN VLMLVFTIIL
     RHTAPKAADS SERLVDKLAH RVASTGLGRV FLQTDDVTDG KQPGTAEDES AERENATRSE
     HADGDTVNLV VDAPEHTAPV VPAGRAGQQR ANVVIIFMDR MMFVCFTFCY VFMICSLLPK
     EMM
//