ID A0A182NP77_9DIPT Unreviewed; 1283 AA.
AC A0A182NP77;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ADIR009462-PA};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR009462-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR009462-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR009462-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR STRING; 7168.A0A182NP77; -.
DR EnsemblMetazoa; ADIR009462-RA; ADIR009462-PA; ADIR009462.
DR VEuPathDB; VectorBase:ADIR009462; -.
DR OrthoDB; 3431519at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR049135; TEP1_CUB2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF136; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR Pfam; PF21412; TEP1_CUB2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 4: Predicted;
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 404..540
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 614..705
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1198..1283
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1283 AA; 145577 MW; C528FCF82B55801C CRC64;
VLVVGPKSVI PSQKYTLTIS NGDEQLSSAN LNLTLVANDA QKTIFQRSTI VDVRKYQMRQ
VDLQIPNIAP SGTVKLMIQR IDGVAYNQEV ALDVQRNLLN GLIQIDKPVY KPGDMVKFRV
IVLDTDLKPP ANLKSIQVRI TDPDGNDVGK WDAAKLFSAV FENRFQIASS PMFGMWKISA
SVDEKVLVSK TFEVKEYVLS SFDLQVAPSV IPLEEHGSLE LTISANYHFG KPVDGTAVVE
LFLLDNKRDQ NQTIQMTGST QITLIFNDNF KVSDDQQDVR VKVTFTERHT NRVITKDTQV
TVYKYPFRVQ LVKESPQFRA GRRFKCQLQF TNHDGTPAKG ITGNVEIQPQ NSEETRTSDN
DGLIKLELPM NNDEQIDITF SDFQYNSYFN EKVTKATSGT DAFLKLELRS AINIKSKRPM
NLIVTCSERM SFFVYFVVTK RKIIDSGFIR PNGQTKYRME QIRASEKMMP RANIIVATVA
KDKTVIWDKL EVDFQQFSNY LDIRIDKEEV KPGNNINLEL NARSGSYVGL AAYDKGLLDF
SAQHHDINWE DVEQLYNGFH ANDYNQYDQF HSMGLFVRPS PSNAELTGPG ERFGLYFTKS
TEKLVQYRTY FPESWLWQNV TIGSTNKHTI EEYVPDTTTS WYLTGFSIDP KHGLGIIKKP
IQLTTKQPFY IVESLPYSIK RGEAAVLQFT LFNNLGGEYM ADVTLYNVAN QTEFVDKSAT
DAIYKKSLSV PPNVGVPVSF LVKARKLGEM VVRVKASIND GLETDGLEKM IRVLPENLVF
NETEPQIFNV QYDENFKMKH NLNINKLSNV DSRKYLFNLY FMDNLEHLLP TPKASAALIV
LEYLDAIDST EEFLKNKAKS MITTNYQEIM KYYNSDGSFS HWPKKKGSIF VTALIAQALN
LASKHISEVD VNVVHKAFDW LESKQHSSGR FDEVGEITYQ DLQDGSRNGV ALTSYVMIAL
LENSHILKND NLKHMIDRGV NYVAERLATI SDAYDLSLAT YAMFLHNHSI QANALDKLVK
MSEFNKTSGR YWPRNSSSIE TTAYGLLCYM RNKQNADAIA VMNWLVNQRE ASGSFSHAQA
TFIGLQALSK ISITLSNVGK QYGIKVTQNG KFKQFRVTST DSNTRQLNVL NGTSKIVDVE
ITGRGFGMYE IVYEYTVDIR NFSKNFKLEL ESNFTNSNYT LNLKVCTIFE PTISMNRSNM
AIVEVNFPSG FVVNKDSITN LSVNKNPIQN TELRYGQTSL VVYYASLGPE ENCFRVTANR
IFKVVFHRPS YVLVHDVHHP GKL
//