ID A0A182NQ64_9DIPT Unreviewed; 1636 AA.
AC A0A182NQ64;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Down syndrome cell adhesion molecule-like protein Dscam2 {ECO:0008006|Google:ProtNLM};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR009799-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR009799-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR009799-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 7168.A0A182NQ64; -.
DR EnsemblMetazoa; ADIR009799-RA; ADIR009799-PA; ADIR009799.
DR VEuPathDB; VectorBase:ADIR009799; -.
DR OrthoDB; 4503820at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 8.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1636
FT /note="Down syndrome cell adhesion molecule-like protein
FT Dscam2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008130227"
FT TRANSMEM 1356..1383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 264..356
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 373..448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 454..550
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 554..642
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 649..734
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 743..831
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 832..929
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 934..1026
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1088..1193
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1198..1295
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1299..1396
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1435..1521
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1539..1630
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 1636 AA; 180518 MW; EBCEC4EF71E61CC5 CRC64;
MAPAPRAAGF MQYIALAILI EQTSHALSSE NLQMPNFLHE LPSSVLFSND TGNSQLVCQA
YGGPQMIIQW ILKDGSLVSS VPGLRQALPN GTLYFPPFAG HLFRTDVHDT TYRCRISYSY
YVLLSHDIRV RAVVRQPYEV KVESADMMLG NTAFLKCFVS SHVREFVHVS SWFSEKEMLL
PSRSDIALRT NSEDSSVRLM RSNSPTGTRY VVTAPGGELC IRNVNEEDRL KRFSCVTVDT
LTGERKTSEA VLLSLKDNTP NMAPSTSQKS VSELTAGKGT SVQLPCNVQG NPVPSFSWFR
ISDTGSLYTV PSSQRIVPSQ SLLFIRNADE RDAGRWICKA FNQFGEQKLE IHLTISTELV
AHIHPQIQII NSGNSALLNC SIFGSEVNKI EWFHNGQELF ANGRTERSMS LLSANTLKID
RVSKKDQGIY QCIVSNARSS AQGSSELKLG ESPPEISYGF VEQNVRTSAY ISLKCSAAGS
PPPQFVWLLD YQPILDVSSL HRYTMDQFLD INSHVTTHLN ISHVHSDDGG LYTCVASNSM
GSAAHKARLN VYGPPYVRAI GPITAVAGEQ IEMHCPFSGH PIQSVRWVRG GNELVSGPRY
SVADVKHGGY LKIYTVDPAQ DRGPYTCIVT GPNGDEGRRE LQLVVHSPPV IEPFSFPKIM
KVGGRAQLTC SVSAGDMPIY FSWKKDGSPI AQDLHVSEKK EEFFSLLVLK DITARHSGRY
TCFATNTAAQ TNYTAELLVQ VPPSWTHEPH DVAIVLGRPI ALACEADGFP QPKITWFRGK
GKLSTDFHSI PSKNNSLSIN YATSPDAGYY MCEAANGIGN SLKKIIHIDV NEAVHFDTPV
KNVSARRNDA VMLECLALGD EPINIIWTHK NQRIDFNNYR YNIIEMKESV GVRSQLSISL
TERYDSGKYV CTAENLYGAS EHVIYLAVQE RPDAPSDLEV MEVSSRQIRL SWKRPYDGMS
PVLSYLVQYQ PVRLGKDPVR DAGHRAGLDG PIAAWDSPST VNVTFSKVNM IKSVPAEKRG
VGWWRSNVLF GAITISSIDG GVRDETSIGG LLPATQYLLR MLAINEIECS SFTSPLVVKT
QEEAPSEAPG GLKVKTGAMG ELVLTWQIPG RASWNGELLG YTVSCVEEKT NINFIASLHN
ISNTTLTVHG WATTKTSIAS LKKFTRYALR IRTYNSIAPG PWSTVVYGTT SEDAPEAEPQ
NVSCSSLSSQ SIKVLWQEPP PQFHNGVLQG YKILYRPLTK NNEFVFPFEI KRTSNLETYL
HALMKATNYS IQVLSFTLSG DGVASVPVYC ATEEDVPEAP AGIKALTLTA DSILVSWLPP
AHPNGIITHY TVYGKDHGKK GSAKRTYFDE CVSTKLLLYT ILIGGYYFPC VFLFCLLSFV
AALHGDYNGG IQFPDNIVRV DETGRPSMFE VRGLSENNKY DFWVTASTTK GEGDPTMVVS
QTTNTRAPAK IASFSRLLKV PVGVSLILEC VAVGNPTPRT RWLTKDQAVT FSQYYVISQG
FLKIHSLEPP IAGNFTCSAK NLFGEDEIHY MLIALQTPNV TQLSIQYTSF DSLRVTWEVA
SDGGASIQGY NLYYRTTTGT WSNVAIPSDQ MAYTLNGLKC GTQYILKINA HNKVGVGMFT
EELAVRTKGK GKFSQK
//
