ID   A0A182NR41_9DIPT        Unreviewed;      1165 AA.
AC   A0A182NR41;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=GRAM domain-containing protein {ECO:0000259|SMART:SM00568};
OS   Anopheles dirus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR010126-PA, ECO:0000313|Proteomes:UP000075884};
RN   [1] {ECO:0000313|Proteomes:UP000075884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles dirus WRAIR2.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ADIR010126-PA}
RP   IDENTIFICATION.
RC   STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR010126-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182NR41; -.
DR   STRING; 7168.A0A182NR41; -.
DR   EnsemblMetazoa; ADIR010126-RA; ADIR010126-PA; ADIR010126.
DR   VEuPathDB; VectorBase:ADIR010126; -.
DR   OrthoDB; 146346at2759; -.
DR   Proteomes; UP000075884; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR031941; DUF4773.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015324; Ribosomal_Rsm22-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13184; 37S RIBOSOMAL PROTEIN S22; 1.
DR   PANTHER; PTHR13184:SF5; METHYLTRANSFERASE LIKE; 1.
DR   Pfam; PF15998; DUF4773; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF09243; Rsm22; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        472..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          197..264
FT                   /note="GRAM"
FT                   /evidence="ECO:0000259|SMART:SM00568"
FT   REGION          152..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          833..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1165 AA;  129592 MW;  B481D7F6A03AA1BE CRC64;
     MRCVLFGEDL RSSDEVIVKI LMRNDARALA GIESHWKSAN SVGLGTRPLP LSSTIEPLSS
     VETPGQPEGA AHLNVLSRSP SHSTAKSDPK IALRSSELLQ DDSSVLKWHR MPLTPAYSTP
     NITADDDTEE VGVRLRKHSA LYRSLKSLSP SARSSTIRSS SPHPLKSFSS TRDTVDKPEK
     SEKHHKKKEG GMSWEQKKFA QHFAQVPDEE VVLDYFSCAL VGDILLQGYL YITQNYFAFY
     SNVFGYVTKL LIPTVSVLDI SREKTAYMFP NAVGVKTRDD RHVFGSFLSR EAAYYLMCSV
     WERATTPQSD SFGSIQHTRL APLHAEGSEG SLDEDSSCYD GNESSFHGKD EIPDLLDSGD
     SNEKQLNATE GGGTNQSSDD STVLQKQKKL KKELLLKSPA IVKSPAILKV AAAEALKGEK
     GIPLLLGDGS SAAGGAVGGS AAATRAVYGD GADRSKLSQI KQKLRHILPS DFGIIHIGLI
     LAVLLALFSC FLAYKIHALQ ARLAAPPIRL GDDTDFYLDV LRWQKRLHSK SKEEAQNVLS
     TNLEQIIRVR KSLETLSLLI QDSVTEGSGE DLIVGLALAR TKEQQEQDQP EGKQLPTFSA
     SPLGGANPCK CLSGVCSCCL GVFSMNGCAN LTYIPEDFAF EFRMIFNNRV LTKNRISGKN
     PKPICVHPPR FDFIEVCANF YDVYFVGRNM HVCMEMNGSF EGYELFSRSF NCLRIGDKGV
     KVMKPGELIG GNVNPSLEAE VDSGDDIEDY DEAYTTKVKC ELDSATEKDI TENGLKPRKH
     RGRIKCNNTA VPTEIHEAIV KCIKDYPLKS LVTDGQRLNN CIRSRKWFPL DTVSNRGTNK
     PMEQVPTSAR RQTSSVFDMH DEYSCLMQLV GRSDAEYAVL NRIFTEINQR DPDLRPRSFL
     DFGAGIGTGT WAVAEHWREH LFEILSVDKS RHMNDLAELV LRQGDSNKPT IVKNVFYRQF
     LPASPERKYD IVLSAFSLFD QLSRRRLYEL VDQLHGTFDK YLIFVEQGSN AGFQLLDGIR
     NHIRRNHGTD DSHLFAPCPH SRSCPRVIKD DGTPCNFEAT YKRNFPSPDG HQQGSILYSY
     LVYRKGPPDS AHGFPRLVRP TAVRSKHCAC HVCSADGKLR DVVFTTAKHG QIVHRCAKAS
     RWGDLLPMQI QWVNTEKGGK TEEET
//