ID A0A182NRZ8_9DIPT Unreviewed; 4875 AA.
AC A0A182NRZ8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Anopheles dirus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7168 {ECO:0000313|EnsemblMetazoa:ADIR010438-PA, ECO:0000313|Proteomes:UP000075884};
RN [1] {ECO:0000313|Proteomes:UP000075884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WRAIR2 {ECO:0000313|Proteomes:UP000075884};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Walton C., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles dirus WRAIR2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ADIR010438-PA}
RP IDENTIFICATION.
RC STRAIN=WRAIR2 {ECO:0000313|EnsemblMetazoa:ADIR010438-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 7168.A0A182NRZ8; -.
DR EnsemblMetazoa; ADIR010438-RA; ADIR010438-PA; ADIR010438.
DR VEuPathDB; VectorBase:ADIR010438; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000075884; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 2194..2331
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2473..2601
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2819..2971
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 213..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1165..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3665..3734
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4636..4663
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 213..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1184
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4875 AA; 559816 MW; 5F44C7CCD93C639D CRC64;
MDFRAIWIRD RLCKILGVFE PRYIDTVLNE LYDELVAFLD DAVTDQRDDH KRILFAYRTF
YERLIEEKVT AFEPDADHEI TGDAGFLGAS NDNELVEVTK IVPTSIKTPI VHICFGIIPE
EKIDPNVRYV YMVRRLCTPI GTYLLSGPLY RPSCRDEPSY PICAQFDLGT FQNLEDCVAE
MPRKVLVGCI RGNLIHNAKE MLERIYRPGV EYQFREPDTR RPKPEKSTSA DEDEPAAVRS
SSRISVGLID YSRPSDFRMK AMQAKKLTPS MALREESALE NSSRQSLADT PSSESNLTQT
KASESTTGDS DARYPLQQTS SERWNALLQE SKEKGQAGRG HQQQQQQPPR PPPEESPMKK
NLEANLEKFI DTLQWTIDHV ECAFGLPTQY NAPNQENITV DEDKFKIKVD IGKTAIEDLT
TLQLEEIVEG WTIYIGKVLR EANEREPTDS TPMAEYNLWV ERELQFNSII EQLKAPFVIQ
VFDALKDNQS NIMKAWPDRF RKLKEALCLA RENVEHLAML QSYLEKIKTG DDFKFILSII
PNITIILRHI WTMSNYYSLD ENMLSLIGKI SYVFAEKVKI LINVDTIFKH SASHIHRCAT
NCVSLLQAWK QSYMDTRAQI EQSGIGSRWE FDKNVLFREI DHMTRISHDM AHIAQVFLDF
ENIFDANFKA MITDPEEVDN TLSKVYRLIN HIISVDYDIF ASSNLANWEA TLDYFHKGVE
QVEHEAKVAL DRCIPSLRSA ELGLELIKNL DRTETRPALA KHLSSKYENI MKQFLAEVGM
VEHEFQKHKT NPPLQRNEPC HVGAVFWARS LLNFIRKSMT AFREFEASKR HAETSLQRNA
FGQYMQLVKH FQEYEKDNFQ KFTAHGTKTV NGVLKRNILK LEFCETILEL QREKKVSKSK
KDKPASERRP SALMTGKDRT RYTNIATAVR WLVNRPDALD PQLALAQKLV RAARNTPSQV
SSDGSATPAS EFKINQAQLM VSAVSQKKIP TWREVIGESV LIEYKLKFAL NFSYDIFDVI
NEGQQFEYLG FALSPTIRMA IMRKDQLFRD VECVSKMVDR YNDIVLNLST PEVYFLRSHL
YEVETIIQAG LGRFTWQSFN IATYAEKCQT LMKSLSSLVS QIGYISNDIK VRIERLESYA
MFELDSDKTK EARQPAAEAV VLKAPTQQKD HHHPHHHPSH RQHHPQQDTR HESVTPTDGP
TMAPASATGR TDETGDLEKR QKRPKKVSIK EADDSVKPCR DYFDTLEKDR NAKTIKLLQL
YDSIGPILIK LESLVLGTFT GECPEMKYYY NHWEKQVFGC FTRFAAKNLE KFMNHLVNSQ
PLFEVDAVLT VPEILMRPSS TDAYSIMISS VKDFLLSWQK YRNLWMYEKM SVCEKFLNQN
VSLAQLDEKF IYYTQIVNEL ERHRPFHDIK SIRVNLKPLI KGIVDHAVEW RNTLGNILAE
RTRQQMIELH EQMVKLRTDL DKHVKELSHF KTVMQTIQTI QSSTLTVELK IHEIQEIYNI
LEEHRIKFPL GDMIMAYHLE KRWKKIYHSA LLRSSKLQPT KAKFAEITQK EIHTFSEELA
KFIAKFRTEG PGTVGLDLDK GVELMDSFGK EIDLMDRQRI ELENAEKLFD IPLTDYKDFL
QCKVEYEEIQ VVYKLYVQQK VAREKWSHTL WANLNPQALL EGIDNFMKEF RMIPKNIRQA
PVGQALDTKM KQFKSSIPLM LSLKDEALRE RHWMKLMEKT GQHFDMSPDR FTLENMFAME
LHKYQDIAEE IINNAIKELA IERSVQEIAH IWQRMCFNMI LYEKGGRTRG HILGATDEIM
QVLEENSMNL QSMAASQFIG PFMPTVQRWE KHLTLISEII DEWISVQRKW LYLEGIFIDG
DISSQLPEEA KNFNVIDEEF RAIMKNSTEN PLVVDVCLVA GRLNDFIRLG SALDGCQKSL
NDYLEQKRRA FPRFYFISTD ELLSILGDSE PTCVQEHIIK MFDNIKSLRF AKDRFDTPTV
TAMISSEGEV MEFENQVPVK DRVECWMNEV LKEMRRTNRF ITKKAIYHYG KDRELARPDW
IMLYQGMVCL AANQVWWTAE VEEVFAKVRH GNKRAMKEYL QEQNRQLDEL VLKVRADLTP
NDRLKFKTIA TIDVHARDII EGFVRDSILD AHEFGWESQL RFYWIREMDN LCVLQCTGKF
DYGYEYMGLN GRLVITPLTD RIYLTITQAL TMNLGGAPAG PAGTGKTETT KDLAKALALL
CVVTNCGEGM DFRAVGTVLS GLTQCGAWGC FDEFNRIDIS VLSVISTQLQ TIRTALVSRV
STFLFEGNEI NLDPKVGIFI TMNPGYAGRT ELPESVKALF RPVTCIMPDL ELICMISLFS
DGFITAKVLA KKMTVLYRMA REQLSKQYHY DWGLRSLNAV LRMAGVNKRK APETSEAATL
MRTLFDMNFP KFVFDDVPLF MGLIKDLFPG VDYPRVGYPE FSEAVRQVLL SDGFVIIQKQ
MDKVQQLYET MMTRHSTMVV GPTGGGKTVV INTLIKAQTN MGLPTKCTVL NPKACSVIEL
YGFLDPNTRD WVDGLFSNIF REMNKPTDRD ERRYVCFDGD VDALWIENMN SVMDDNKLLT
LANGERIRLN SYCALLFEVG DLAYASPATV SRAGMVYLDP KNLGYECYWE RWLKARYAEE
QEVLQKTFSA IIPIAIDYIL EGVDGNNQED PLECVIRQTN LNMVVQLCQF YDSIFPMKTA
TCAHEEDVVE CGFIQCIYLS LGAALLEESR VRFDGFIKRK LEKTAAEDTQ ENPASTGQLP
TLKPTLFDYF FDIERKQWLA WEWVIPSYEH DAGLHFSDIL VPTMDTLKIE KILDLMNKVR
RPVVLVGDPG TSKTAVISHF LRHLNRDSFI VLNINFSSRT SSMDVQKTIE AAVEKRTKDI
FGPPVGKKLV TFIDDMNMPQ VDNYGTQQPI ALLKLLLEKE GMFDRTKDLS WKKFKDMSFI
AAMGRAGGGR NEVDSRFISM FSVINIIFPN DATLHHIYMS ILKGHLHPFP PDLGANAHKL
IEMTLALFKT LVTKLPPTPS KFHYIFNMKD LSRIFAGLLQ IHPHFFKETR HLVRVWRNEF
ARVICDRLIN EQDQQFLEQQ LSERIMEHFP IPRSFRHTVQ IDQQQQQQPG RLESRIKSAV
VELSVAQYAL RNPLLFGDYR NAVNPAEERY YEDLLDYEAI YFLFQEILME YNEQRSKMHL
VLFEDCLEHL TRVHRTLRMH RGHVMLVGIG GSGKQSITRL AAFAAGCEIF EIVLSRGYNE
ASFREDLKTL FLQVGVRNVK TCFIFKAAQI AEEGFLEFIN NILTTGMVPA MFTDDEKDQI
IGQCRGAAQE HGYAPSKDGV WSFFLDRAIR NLHVVLCMSP EGDALRNRCR NFPGLVGSTT
IDWVFPWPQQ ALFAVAKVFL TDHPKIPENY REPIIAHIVH VHQSLKSYNV QYLMKLRRKN
FVTPKHYLDF INTYLKLIEE KDNFIMQQCA RLSDGIEKIN EASLQIDQLS IIVEEQRKNV
IEAADRCESM LAGIETSTEK ANVKKLEASE KSVEVEQQKK IITVEKAEAE EALAAALPAL
EVARLALSDL DKSDITEIRS FATPPEPVQV VCECVAIIKG YKDISWKTAK GMMSEGNFLR
SLQELDCDAI TQKQVATVRA NMKRSQKLDE MQSISKAGFG LLKFVRAVLG YCDVFKEIKP
KKDRVAFLES ELNGQIRLLV KLTNEIGKLE NELAELNGKY ANAIKEKQML QEMMEQAERR
LLAADKLISG LSSERDRWVI DLGRLQVERT KVIGNALLSA SFLAYMGPFS WEFRRAILFD
DWLANVVARD IPFTVPYRVN GSLSSDLEQS TWASEGLPPD ELSIQNGILT TRASRFPLCI
DPQQQALSWI RKREAGNNLK TLSFNDKDFL RQLEMAIKYG TPVLFQDVDD YIDPVIDNVL
ERNVRVQAGR QIVVIGDKEV DVDANFRLYL TTKLANPNFD PAVYAKAQVI NYTVTVSGLE
DQLLSVVVRA ERSDLEEQRE TLIAETSANK ALLQNLEDSL LRELATSTGN MLDNVELVTT
LESTKEKAAE VSQKIVLAEQ TSKEIDQLRN GYRLAAQRGA ILYFVLSDMA AVNAMYQYSL
NSYLEVFSYS LRKAVPDNVL SKRLDNIINT LTRNVYEYGC IGIFEKHKLL YSFQITIKLE
LNRGTLSQAE VDFFIKGKVS LEKTERACPV TWISEKGWQD IVMLGEMFPE KFADLPGHIE
GNIYEWSSWY DLDDAGGYEY PGNFEDRMSP YDHLLLMRCL RVDRVYRMLN NYVAQTMGEE
FITPPILSFD AIYEQSTAST PVVFILSPGS DPTSDLMKLA DRCGFGGPKF KHISLGQGQE
GAALRLLYAA LEQGMWLMLQ NGHLLISFIK TLEKIIDSIE KPHPDFRLWI TTDATPTFPI
GILQKSLKVV TEPPNGLKMN LRATFFKLRQ QTLDSCTHHA FRPLAYVLAF FHAVLQERRK
YGKLGWNICY DFNESDFSVC LQILDTYLTK AADSRDSRMP WNSLKYLIGE VMYGGRVIDD
FDRRVVKTYM DEYMGDFLFD TFQPFNFYAD ESFTYAPIAA PNRDEFIAAI DKLPLNNTPE
VFGLHSNAEI GYYTAAVRET WAHLIDLQPQ TGADTGGISR DEFIDRAAVD ILKKLPKPFD
IWRVKKAYQV NVTPICVVLL QELERYNRLI QRMEHTLNQL RKALAGEIGM DAVLDNVAHA
LFNGQLPDDW RKLAPATCKQ LGDWIEHLLR RSQQYKYWSV SGEPLVMWLS GLHIPESYLT
ALVQIACRKN NWPLDRSTLF TSVTRFLRED EIEERPEAGC YVTGLYLQGA RWDPENRCLT
RSTPKVLVEP LPVLSIVPIE THRLKLQNTF RTPVYTTSER RNAMGVGLVF EADLRTEEHC
SLWVLQGVCL TMNLD
//
